An oxygen-carrying biomimetic nano antidote and its preparation method and application

Abstract

The invention provides an oxygen-carrying biomimetic nano antidote and its preparation method and application. The red blood cell membrane modified by the phospholipid derivative oleic acid oxyethylphosphorylcholine is used to wrap the oxygen-carrying liquid perfluorocarbon compound to obtain the oxygen-carrying liquid perfluorocarbon compound. Functional biomimetic nano antidote. The obtained biomimetic nano antidote has good detoxification effect, can weaken the hemolysis induced by the toxin, alleviate the hypoxia phenomenon caused by the snake bite, reduce the degeneration and necrosis of tissue cells and promote wound healing.

Description

technical field [0001] The invention belongs to the field of nano drug carriers, and in particular relates to an oxygen-carrying biomimetic nano antidote and its preparation method and application. Background technique [0002] Rapid and accurate application of highly specific antidote plays an important role in the treatment of poisoning events and the rescue of patients. Taking snake venom detoxification as an example, poisonous snake bite is a common clinical emergency, which seriously threatens the safety of human life. The antivenoms commonly used in the market can effectively treat systemic toxic reactions such as snake venom neurotoxicity, cardiotoxicity, hemolysis and blood coagulation, but have local effects on the bleeding, edema, pain, muscle necrosis and secondary infection caused by snake venom. Limited, and there are many problems including: (1) antivenom is highly specific and only effective for snake species of the same genus. At present, there are only 4 k...

AI Technical Summary

Problems solved by technology

The antivenoms commonly used in the market can effectively treat systemic toxic reactions such as snake venom neurotoxicity, cardiotoxicity, hemolysis and blood coagulation, but have local effects on the bleeding, edema, pain, muscle necrosis and secondary infection caused by snake venom. Limited, and there are many problems including: (1) antivenom is highly specific and only effective against snake species of the same family and genus

However, most people do not have the relevant knowledge to identify venomous snake species, and they are prone to misjudgment due to failure to clearly observe the appearance characteristics of venomous snakes

(2) The dosage of antivenom serum depends on the amount of snakebite injected venom, which needs to be estimated by doctors based on experience, and sometimes there is a large deviation from the actual value. Therefore, it is recommended to use small doses in clinical practice to avoid adverse reactions such as allergies or serum sickness caused by excessive doses. response, but the final therapeutic effect cannot be guaranteed

(3) The production cost of serum is high, the scrap rate is high, and the profit is low, so many pharmaceutical companies dare not get involved in it. Most of the time, antivenom serum is in short supply.

However, there are still many deficiencies when hyperbaric oxygen is used to assist snakebite treatment, for example: (1) The treatment process is highly dependent on equipment, which is not conducive to the treatment of snakebite for people in remote areas; (2) The operation of the equipment needs to be very standardized, A little carelessness can lead to oxygen poisoning or barotrauma; (3) Individual differences are large, and the pressure should be selected according to whether there is an emphysema-like cyst, whether the non-compressible air cavity communicates well with the outside world, etc., and is not suitable for emergencies Oxygenation, etc.

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