36results about How to "Improve the effectiveness of protection" patented technology

The present invention is related to a biodegradable high-efficiency dengue vaccine, a method for making the same, and a pharmaceutical composition comprising the same. The biodegradable high-efficiency dengue vaccine comprises a biodegradable nanocomplex with electric properties holding a dengue viral protein inside. An organism has antibody responses after vaccination with the biodegradable nanocomplex twice. Accordingly, in comparison with the Alum adjuvant and Ribi adjuvant used in the traditional dengue vaccine of the prior art, the vaccination times in the present invention is decreased to further reduce the vaccination cost, so the biodegradable high-efficiency dengue vaccine is good for being a commercial vaccine.

The present invention relates to a streptococcus antigen C5a and a preparation method thereof. The streptococcus protective antigen C5a is an SEZC5a recombinant protein, which consists of 571 amino acids and has a molecular weight of 60.3kDa; a forward primer has one BamHI restriction enzyme cutting site, and a reverse primer has one EcoRI restriction enzyme cutting site. According to the preparation method of the streptococcus protective antigen C5a, the SEZ C5a recombinant protein is treated with cloning, expression and purification; and a series of biological engineering technologies and experiments on mice are applied to conduct system analysis on an rSCPZ. After vaccination, the rSCPZ can provide high protective efficacy; an anti-rSCPZ mice double-immunized serum has significant passive immune protection on mice; and the mice immunized by the rSCPZ show high level of antibody titer in serum. The anti-rSCPZ antibody can induce high level of bactericidal capability; an scpZ gene has a transcription level in SEZ (Streptococcus zooepidemicus) infected mice higher than that of culture in vitro; and the rSCPZ can adhere to hep-2 cells and inhibit cell infection ability of SEZ.

The invention discloses a detecting system and a detecting method for a safety testing mode. The detecting system is used for preventing entering the safety testing mode after a chip testing circuit is abandoned. The detecting system for the safety testing mode comprises a time sequence logic control module, a detecting circuit module and a triggering module. The triggering module is used for generating a high-level or low-level triggering signal according to an on-off state. The time sequence logic control module outputs a high-level testing mode signal according to the low-level triggering signal, thereby making a chip enter the safety testing mode, or the time sequence logic control module outputs a low-level testing mode signal according to the high-level triggering signal, thereby making the detecting circuit module output a self-destroying signal for performing a self-destroying operation. Therefore the detecting system for the safety testing mode improves protecting effectiveness for chip sensitive information and accords with a majority of technological realizing requirements. The detecting system can be widely applied to various safety chips.

The invention discloses a superplastic stone blocking net. The superplastic stone blocking net comprises steel wire nets, steel columns, steel column bases, anchor rods and anchor rod bases; the steel column bases and the anchor rod bases are fixed on a foundation; a first end of every steel column is connected with the corresponding steel column base in a rotatable mode; the anchor rods are formed by superplastic materials; a first end of every anchor rod is connected with the corresponding steel column in a rotatable mode; a second end of every anchor rod is connected with the corresponding anchor rod base in a rotatable mode; the steel wire nets are formed by superplastic materials; the bilateral sides of every steel wire net are connected with the two adjacent steel columns. According to the superplastic stone blocking net, a decompressor or decompression ring device of a passive side slope protection system is omitted, the force transfer path of the stone blocking net is changed through the design of rotatable structures of the steel columns and the steel column bases, the anchor rods and the steel columns and the anchor rods and the anchor rod bases, and accordingly concentrated loads are effectively dispersed into different stress units and accordingly the cracking of the steel wire nets under the large load impact is effectively prevented and the protection effect is greatly improved.

The invention relates to an oxygen carrying coronary contrast medium, which comprises a contrast medium and a hemoglobin oxygen carrying carrier. According to the condition whether the contrast medium is mixed with the hemoglobin oxygen carrying carrier or not before using, the oxygen carrying coronary contrast medium has the following two types of: 1, storing the hemoglobin oxygen carrying carrier and the contrast medium respectively, wherein the hemoglobin oxygen carrying carrier is contained in dilution solution which is diluted by a diluent until the hemoglobin concentration is between 0.1 and 5g / dL, the pH value of the dilution solution is between 7.0 and 7.4; and making the hemoglobin oxygen carrying carrier contained in the dilution solution in an oxygen saturation state by oxygenating before using; and 2, forming mixed liquor by using the hemoglobin oxygen carrying carrier and the contrast medium, wherein the proportion of the contrast medium to the hemoglobin oxygen carrying carrier is limited by the hemoglobin concentration which is between 0.1 and 5 g / dL in the mixed liquor, and the pH value of the mixed liquor is between 7.0 and 7.4; and making the hemoglobin oxygen carrying carrier contained in the mixed liquor in the oxygen saturation state by oxygenating before using.

The invention relates to a streptococcus equi subsp. zooepidemicus (SEZ) protective antigen HP0623 and A preparation method thereof. The SEZ protective antigen HP0623 is a SEZ HP0623 recombinant protein, is composed of 429 amino acid residues, and has a molecular weight of 47.04 kDa. The preparation method comprises steps of gene clone, enzyme cutting and enzyme linking, inducible expression, and protein purification. The HP0623 can be used to prepare vaccines. The provided SEZ protective antigen HP0623 expresses good immunogenicity in mouse experiments; the generated antibody can provide a strong protective force and induce a high level sterilizing performance; the SEZ protective antigen HP0623 is located on the surface of SEZ, and rHP0623 can inhibit the adhesion of SEZ on Hep-2 cells.

The invention discloses a safety belt system, a safety belt control method, a vehicle and a readable storage medium. The safety belt system comprises a webbing, a locking tongue, a lower end piece, a seatbelt retractor and a lock buckle, and the locking tongue is movably arranged on the webbing upper; the lower end piece is connected with one end of the webbing; the seat belt retractor includes a coil spring assembly and a movable guide sleeve assembly, and the end of the webbing away from the lower end sheet is connected with the reel of the coil spring assembly through the webbing channel opening of the seat belt retractor, and is movable. The guide sleeve assembly controls the tightening force of the webbing; the lock catch is engaged with the lock tongue. The invention can improve the wearing comfort of the safety belt under the condition of ensuring the protection effect of the safety belt as much as possible.

The present invention adopts the monoclonal antibody 5D9 which has neutralizing activity to both PRRSV-I and PRRSV-II type viruses to make an immune enhancer, and when the formed immune complex is combined with an adjuvant to immunize mice, IFN-γ secretes T cells significantly Increased, suggesting that in the process of inactivated virus immunization, combined immunization with PRRSV-specific antibody 5D9 and normal oil-in-water adjuvant can enhance the CTL response. Animal experiments show that the immune protection rate of the immune complex prepared by the present invention can achieve higher protective efficacy than the vaccine prepared by only using the commercial adjuvant ISA 206 and the commercial attenuated vaccine.