Oxygen carrying coronary contrast medium and preparation method thereof

A coronary contrast agent and contrast agent technology, applied in the field of coronary contrast agent, can solve the problems of aggravating the burden of myocardial ischemia and hypoxia, hindering myocardial blood supply, myocardial tissue ischemia, etc., and achieve the alleviation of myocardial tissue ischemia and hypoxia damage , reduce myocardial ischemia and hypoxia damage, and meet the effect of oxygen supply and demand balance

Active Publication Date: 2011-07-06
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The currently used contrast agents (including non-ionic and ionic contrast agents) have no oxygen-carrying function, so it is impossible to avoid the potential ischemic and hypoxic damage to the myocardial tissue during coronary angiography, but there is a risk of aggravation
It has been clinically shown that the side effects and complications of coronary intervention are closely related to the ischemic and hypoxic injury caused by the contrast medium, except that the patient is allergic to the contrast medium itself. Coronary artery spasm, blocking coronary arteries, resulting in reduced blood supply to myocardial tissue; (2) Improper operation, such as catheter insertion too deep, blocking or entering the conolar artery, hindering myocardial blood supply
If th

Method used

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  • Oxygen carrying coronary contrast medium and preparation method thereof
  • Oxygen carrying coronary contrast medium and preparation method thereof
  • Oxygen carrying coronary contrast medium and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0044] Example 1

[0045] In the oxygen-carrying coronary artery contrast agent in this embodiment, the hemoglobin-based oxygen-carrying carrier diluent and the contrast agent are stored separately, and the preparation method of the hemoglobin-based oxygen-carrying carrier diluent is as follows: Take the above-mentioned polymerized hemoglobin at a low temperature of 4°C Solution 10mL, add lactated Ringer test solution to dilute to 20mL, so that the final concentration of hemoglobin in the hemoglobin oxygen-carrying carrier diluent is 5g / dL, and then adjust the pH value of the diluent with a concentration of 0.1M sodium bicarbonate solution to 7.0~7.4. Immediately before use, the hemoglobin-type oxygen-carrying carrier diluent is oxygenated by bubbling with 100% oxygen for 30 minutes to make the hemoglobin-type oxygen-carrying carrier contained in the oxygen saturated state, and then the water bath is heated to 37°C.

[0046] Experimental operation:

[0047] 1. Select 8 adult male B...

Example Embodiment

[0062] Example 2

[0063] The oxygen-carrying coronary artery contrast agent in this embodiment is a mixed solution formed by a hemoglobin-based oxygen-carrying carrier and a contrast agent. The preparation method is as follows: at 4°C, take 1 mL of the polymerized hemoglobin solution and add iohexol ( Onipex) is diluted to 100 mL, and the final concentration of hemoglobin in the mixed solution formed after uniform mixing is 0.1 g / dL, and then the pH value of the mixed solution is adjusted to 7.0-7.4 with a potassium bicarbonate solution with a concentration of 0.1 M. Immediately before use, bubbling oxygenation with 95% oxygen + 5% carbon dioxide mixed gas for 15 minutes to make the hemoglobin contained in the mixed liquid carry the oxygen carrier to the oxygen saturation state, and then the prepared oxygen-carrying coronary artery contrast agent Heat up to 37°C with a water bath.

[0064] Experimental operation:

[0065] 1. Select 6 adult male Beagle dogs with normal heart functi...

Example Embodiment

[0079] Example 3

[0080] The oxygen-carrying coronary artery contrast agent in this embodiment is a mixed solution formed by a hemoglobin-based oxygen-carrying carrier and a contrast agent. The preparation method is as follows: at 4°C, take 1 mL of the modified hemoglobin solution and add iohexol ( Onipex) was diluted to 20 mL, and the final concentration of hemoglobin in the mixed solution formed after uniform mixing was 0.5 g / dL, and then the pH value of the mixed solution was adjusted to 7.0-7.4 with a concentration of 0.1 M sodium bicarbonate solution. Immediately before use, bubbling oxygenation with 95% oxygen + 5% carbon dioxide mixed gas for 15 minutes to make the hemoglobin contained in the mixed liquid carry the oxygen carrier to the oxygen saturation state, and then the prepared oxygen-carrying coronary artery contrast agent Heat up to 37°C with a water bath.

[0081] Experimental operation:

[0082] 1. Select 7 adult male Beagle dogs with normal heart function, weighin...

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Abstract

The invention relates to an oxygen carrying coronary contrast medium, which comprises a contrast medium and a hemoglobin oxygen carrying carrier. According to the condition whether the contrast medium is mixed with the hemoglobin oxygen carrying carrier or not before using, the oxygen carrying coronary contrast medium has the following two types of: 1, storing the hemoglobin oxygen carrying carrier and the contrast medium respectively, wherein the hemoglobin oxygen carrying carrier is contained in dilution solution which is diluted by a diluent until the hemoglobin concentration is between 0.1 and 5g/dL, the pH value of the dilution solution is between 7.0 and 7.4; and making the hemoglobin oxygen carrying carrier contained in the dilution solution in an oxygen saturation state by oxygenating before using; and 2, forming mixed liquor by using the hemoglobin oxygen carrying carrier and the contrast medium, wherein the proportion of the contrast medium to the hemoglobin oxygen carrying carrier is limited by the hemoglobin concentration which is between 0.1 and 5 g/dL in the mixed liquor, and the pH value of the mixed liquor is between 7.0 and 7.4; and making the hemoglobin oxygen carrying carrier contained in the mixed liquor in the oxygen saturation state by oxygenating before using.

Description

technical field [0001] The invention belongs to the field of coronary contrast agents, in particular to an oxygen-carrying coronary contrast agent with heart protection function and a preparation method thereof. Background technique [0002] In recent years, with the widespread development of coronary interventional therapy, the side effects and complications caused by contrast agents have attracted more and more clinical attention. Among them, ventricular fibrillation is one of the most serious complications of coronary angiography, with an incidence rate of 0.38% to 0.9%, and a high fatality rate. Moreover, cholesterol crystal embolism diseases accompanied by coronary angiography and other interventional treatments are also increasing, which must be paid enough attention in clinical work. Although, with the continuous development and improvement of imaging equipment and technology, the incidence of complications of various coronary interventions such as ventricular fibril...

Claims

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Application Information

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IPC IPC(8): A61K49/00
Inventor 李涛冯沅李茜刘进赁可周荣华李晨张璞朱达
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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