42results about How to "Can realize industrial production" patented technology

The invention discloses a three-dimensional connected honeycomb porous calcium phosphate ceramic artificial bone material. A plurality of longitudinal straight-through holes are distributed in the calcium phosphate ceramic artificial bone material in a honeycomb manner; and a plurality of transverse through holes are distributed in the hole walls of the straight-through holes to connect the adjacent straight-through holes. The invention also discloses a preparation method of the three-dimensional connected honeycomb porous calcium phosphate ceramic artificial bone material. The three-dimensional connected honeycomb porous calcium phosphate ceramic artificial bone material is prepared once through an extrusion molding technology and a pore forming agent adding technology. The straight-through holes are helpful for growing newborn bone tissues and forming blood vessels, and the three-dimensional connected holes are helpful for connecting cells into pieces and facilitate transportation of nutrient substances and discharging of metabolites. The preparation method is simple and can realize continuous production; and the prepared porous calcium phosphate ceramic has the advantages of high porosity, high connectivity and good mechanical performances.

The invention belongs to the technical field of constructional engineering and relates to an extrusion molding composite thermal insulation plate integrated with main body structure concrete. The extrusion molding composite thermal insulation plate integrated with main body structure concrete is characterized in that one face of an extrusion molding plate is provided with mutually crossed arc-shaped grooves, two faces of the extrusion molding plate are both provided with an adhesion agent protective layer, and reinforcing steel bars are arranged in the extrusion molding plate grooves. The reinforcing steel bars form a reinforcing steel bar mesh on the extrusion molding plate, the reinforcing steel bar mesh is provided with fiberglass cloth, a thermal insulation mortar layer wraps the reinforcing steel bar mesh and the fiberglass cloth, and the thermal insulation mortar layer is combined with the extrusion molding plate through the adhesion agent to form a thermal insulation plate. The thermal insulation plate is provided with an anchoring bolt hole, the thermal insulation mortar layer corresponding to the anchoring bolt hole is provided with a countersink, an anchoring bolt is arranged in the anchoring bolt hole, and the other end of the anchoring bolt extends out of the extrusion molding platen and the adhesion agent protective layer and is fastened through a nut. The extrusion molding composite thermal insulation plate integrated with main body structure concrete is good in fireproofing safety, simplifies construction procedures, can improve construction progress, lowers building cost, can achieve industrialized production, is better guaranteed in quality of all aspects and avoids potential quality hazard including hollowing, cracking, water seepage, falling-off and the like brought by complicated operation sequence to the largest extent.

The invention discloses amorphous selexipag, which is characterized in that the characteristic peak of the selexipag does not exist in an X-ray powder diffraction spectrum. The invention discloses a preparation method of the amorphous selexipag, a solid dispersoid of the amorphous selexipag and a pharmaceutic adjuvant and a preparation method of the solid dispersoid. The solid dispersoid is prepared from the selexipag and the pharmaceutic adjuvant; the weight ratio of the selexipag to the pharmaceutic adjuvant is 1 to (0.1 to 100), wherein the selexipag is in an amorphous state; the X-ray powder diffraction spectrum of the solid dispersoid has no characteristic peak of a crystal of the selexipag after the background peak of the pharmaceutic adjuvant is deducted. The solid dispersoid of the selexipag and the pharmaceutic adjuvant, which is provided by the invention, is favorable in stability and dispersity, is used for increasing the dissolution rate of the selexipag, is used for more beneficially improving the bioavailability of a medicinal preparation and the absorption of an organism to a medicine, and in an accelerated test condition, can be used for maintaining favorable physical stability and chemical stability. The preparation method of the amorphous solid dispersoid, which is provided by the invention, is simple to operate, low in cost, good in repeatability and easy to realize, and is suitable for industrialized production.

The invention discloses a synthesis method of AT-TBA, which comprises the following steps: sequentially BPTA, methanol, water and NaOH into a reaction vessel, stirring to react at 45-50 DEG C for 8-10 hours, adding activated carbon, stirring for 1-2 hours, filtering, cooling the filtrate to below 20 DEG C, regulating the pH value to 7, distilling under reduced pressure at 40-45 DEG C to recycle the methanol, dissolving the residual filtrate in water, regulating the pH value to 3, cooling to 5 DEG C, continuing stirring for 0.5-1 hour, carrying out vacuum filtration, sequentially washing the filter cake with water and acetonitrile, and carrying out vacuum drying on the filter cake to obtain a light yellow solid which is the AT-TBA. The synthesis method disclosed by the invention has the advantages of simple technique, easily controlled conditions and high yield, and can implement industrial production.

The invention provides a preparation method of a tin selenide photovoltaic film, and belongs to the technical field of photovoltaic film preparation. The tin selenide photovoltaic film is obtained through the following steps that firstly a substrate is cleaned, then SnCl2.2H2O and SeO2 are put in a solvent, a precursor film is obtained on the substrate by using a spin coating method, the precursor film is dried and put in a closed container having hydrazine hydrate so that the precursor film sample is enabled not to be contacted with the hydrazine hydrate, the closed container in which the precursor film sample is arranged is heated, and the sample is taken out to be cooled and dried so that the tin selenide photovoltaic film can be obtained. The preparation method does not require the high temperature and high vacuum condition and has low requirement for instruments and equipment so that the production cost is low, the production efficiency is high and operation is easy. The obtained tin selenide photovoltaic film has great continuity and uniformity, and the new process is easy to control the component and the structure of the target product so that the low-cost and industrialized production method can be provided for preparing the high-performance tin selenide photovoltaic film.

The invention discloses solid dispersoid of amorphous lesinurad and a pharmaceutic adjuvant and a preparation method of the solid dispersoid. The solid dispersoid is prepared from the lesinurad and the pharmaceutic adjuvant; the weight ratio of the lesinurad to the pharmaceutic adjuvant is 1 to (0.1 to 100), wherein the lesinurad is in an amorphous state; the X-ray powder diffraction spectrum of the solid dispersoid has no the characteristic peak of a crystal of the lesinurad after the background peak of the pharmaceutic adjuvant is deducted. The solid dispersoid of the amorphous lesinurad and the pharmaceutic adjuvant, which is provided by the invention, is favorable in stability and dispersity, is used for increasing the dissolution rate of the lesinurad, is used for more beneficially improving the bioavailability of a medicinal preparation and the absorption of an organism to a medicine, and in an accelerated test condition, can be used for maintaining favorable physical stability and chemical stability. The preparation method of the amorphous solid dispersoid, which is provided by the invention, is simple to operate, low in cost, good in repeatability and easy to realize, and is suitable for industrialized production.

The invention provides a pharmaceutical composition containing amorphous vortioxetine hydrobromide and a preparation method thereof. The pharmaceutical composition comprises vortioxetine hydrobromide,at least one organic carrier and at least one adsorbent, wherein a weight ratio of vortioxetine hydrobromide to all the organic carriers is 1: 0.1-10, and a weight ratio of vortioxetine hydrobromideto all the adsorbents is 1: 0.1-10; vortioxetine hydrobromide in the composition is in an amorphous state; and after deduction of the background peaks of pharmaceutical adjuvants, the X-ray powder diffraction spectrum of the composition is free of characteristic peaks of the crystal of vortioxetine hydrobromide. The composition of vortioxetine hydrobromide and the pharmaceutical adjuvants has goodstability and dispersibility; the dissolution rate of vortioxetine hydrobromide is improved; the bioavailability of a medicinal preparation and body absorption of vortioxetine hydrobromide are improved; and under accelerated test conditions, the composition can maintain good physical stability and chemical stability. The preparation method for the amorphous composition of the invention has the advantages of simple operation, low cost, good reproducibility, easy realization and suitability for industrialized production.

The invention relates to a method for preparing a copper-aluminum-sulfur film, and belongs to the technical field of preparation of photoelectric films. The method comprises the following steps of: firstly cleaning a substrate; then placing CuCl2.2H2O and Al(NO3)3.9H2O into a solvent, and applying a spincoating method to obtain a precursor film on the substrate; drying the precursor film, and placing the precursor film into a closable container filled with hydrazine hydrate and sublimed sulfur, wherein a precursor film sample is not contacted with the hydrazine hydrate and the sublimed sulfur; finally drying the sample to obtain the copper-aluminum-sulfur photoelectric film. The method disclosed by the invention has the advantages of no need of high-temperature high-vacuum condition, low requirement on instruments and equipment, low production cost, high production efficiency and easiness for operation. The obtained copper-aluminum-sulfur photoelectric film has better continuity and uniformity. The new process can be used for easily controlling the components and structure of a target product and provides the preparation method which is low in cost and can realize industrialization for preparing the high-property copper-aluminum-sulfur photoelectric film.

The invention relates to novel crystal forms A, B, C and D of clorsulon as well as preparation methods and applications of the crystal forms. The crystal forms have excellent properties in physical and chemical stability and processing adaptability.

The present invention provides a recombinant prokaryotic expression protein antigen for detecting autochthonous trichinella spiralis antibody and its preparation method. Said product can be used as detection antigen of indirect-ELISA and Dot-ELISA method for detecting autochthonous trichinella spiralis antibody, also can be used as gene engineering subunit vaccine for preventing autochthonous trichinella spiralis infection. The preparation process of said product includes the following steps: (1) designing specific primer for amplifying TNPG gene; (2), utilizing PCR amplification to obtain TNPG gene segment; (3), cloning TNPG gene and sequencing, and making identification; (4), directionally subcloning TNPG gene to pET-3a prokaryotic expression vector; (5), induced expression of TNPG gene in colibacillus; and (6), affinity chromatography purification of TNPG gene expression protein.

The invention discloses wear-resistant impact-resistant waterborne epoxy floor paint and a preparation method thereof. The preparation method comprises the following steps: S1, preparing an allyltriphenylphosphonium bromide/graphene oxide compound; s2, preparing a quaternary ammonium salt polymer intermediate; and S3, preparing the wear-resistant impact-resistant waterborne epoxy floor paint. According to the invention, allyltriphenylphosphonium bromide is introduced into a graphene oxide sheet layer, and an allyltriphenylphosphonium bromide molecular chain can be utilized to expand the sheet layer structure of the graphene oxide, so that the interface bonding force between the allyltriphenylphosphonium bromide/graphene oxide compound and an epoxy floor paint system is increased; the wear resistance and the impact resistance of the epoxy floor are optimized; and the special phenylphosphine structure of the allyl triphenyl phosphonium bromide has high thermal stability, so that the weather resistance of the epoxy floor paint can be greatly improved, the aging of the epoxy floor paint is prevented, and the service life of the epoxy floor paint is greatly prolonged.