42results about How to "Can realize industrial production" patented technology

The invention discloses a three-dimensional connected honeycomb porous calcium phosphate ceramic artificial bone material. A plurality of longitudinal straight-through holes are distributed in the calcium phosphate ceramic artificial bone material in a honeycomb manner; and a plurality of transverse through holes are distributed in the hole walls of the straight-through holes to connect the adjacent straight-through holes. The invention also discloses a preparation method of the three-dimensional connected honeycomb porous calcium phosphate ceramic artificial bone material. The three-dimensional connected honeycomb porous calcium phosphate ceramic artificial bone material is prepared once through an extrusion molding technology and a pore forming agent adding technology. The straight-through holes are helpful for growing newborn bone tissues and forming blood vessels, and the three-dimensional connected holes are helpful for connecting cells into pieces and facilitate transportation of nutrient substances and discharging of metabolites. The preparation method is simple and can realize continuous production; and the prepared porous calcium phosphate ceramic has the advantages of high porosity, high connectivity and good mechanical performances.

The invention provides a method for preparing a tin selenide photoelectric thin film material, belonging to the technical field of photoelectric thin film preparation. The method comprises the following steps: firstly washing a chip, then putting SnCl2.2H2O and SeO2 into solvents, obtaining a precursor thin film on the chip by a spin coating method and drying the precursor thin film, putting the precursor thin film into a closed container with diamide hydrate, ensuring the precursor thin film sample not to be contacted with diamide hydrate, heating the closed container filled with the precursor thin film sample, taking out the sample and cooling and drying the sample, thus obtaining the tin selenide photoelectric thin film. The method has the following beneficial effects: the method dispenses with the conditions of high temperature and high vacuum, has low requirements for apparatuses, is low in production cost and high in production efficiency and is easy to operate; the tin selenide photoelectric thin film has better continuity and uniformity; the components and structure of the target product are easy to control by the new process; and the production method which is low in cost and can realize industrialization is provided for preparing the tin selenide photoelectric thin film with high performance.

The invention relates to a manufacture device and method for a large-size fine-grain homogeneous aluminum alloy cast ingot, belonging to the field of metal material machinery. The device mainly comprises a uniform cooler, a thermal ejector, an electromagnetic stirrer, a crystallizer and a dummy ingot, wherein the thermal ejector is arranged above the crystallizer; the electromagnetic stirrer is arranged on the periphery of the thermal ejector and the crystallizer; the dummy ingot is arranged below the crystallizer; the uniform cooler is arranged in the crystallizer; and the uniform cooler consists of an inner pipe and an outer pipe. According to the manufacture device and method, through special coupling treatment of uniform cooling in the crystallizer and electromagnetic stirring outside the crystallizer is applied to an alloy melt, so that effective control on uniformity of a temperature field and a component field of the large-size alloy melt is realized, and the large-size aluminum alloy cast ingot with uniform and fine structure and uniform components is manufactured. The manufacture device is simple in structure, feasible in method, obvious in effect, high in production efficiency and easy for combination with large-scale industrial production, and has a wide industrial application prospect in the fields of aerospace, rail transportation and manufacture of ships and the like.

The invention belongs to the technical field of constructional engineering and relates to an extrusion molding composite thermal insulation plate integrated with main body structure concrete. The extrusion molding composite thermal insulation plate integrated with main body structure concrete is characterized in that one face of an extrusion molding plate is provided with mutually crossed arc-shaped grooves, two faces of the extrusion molding plate are both provided with an adhesion agent protective layer, and reinforcing steel bars are arranged in the extrusion molding plate grooves. The reinforcing steel bars form a reinforcing steel bar mesh on the extrusion molding plate, the reinforcing steel bar mesh is provided with fiberglass cloth, a thermal insulation mortar layer wraps the reinforcing steel bar mesh and the fiberglass cloth, and the thermal insulation mortar layer is combined with the extrusion molding plate through the adhesion agent to form a thermal insulation plate. The thermal insulation plate is provided with an anchoring bolt hole, the thermal insulation mortar layer corresponding to the anchoring bolt hole is provided with a countersink, an anchoring bolt is arranged in the anchoring bolt hole, and the other end of the anchoring bolt extends out of the extrusion molding platen and the adhesion agent protective layer and is fastened through a nut. The extrusion molding composite thermal insulation plate integrated with main body structure concrete is good in fireproofing safety, simplifies construction procedures, can improve construction progress, lowers building cost, can achieve industrialized production, is better guaranteed in quality of all aspects and avoids potential quality hazard including hollowing, cracking, water seepage, falling-off and the like brought by complicated operation sequence to the largest extent.

The invention belongs to the technical field of constructional engineering and discloses a composite heat-insulating superimposed sheet integrated with a concrete body structure. The sheet is characterized in that interface agent protective layers are arranged on both sides of a polystyrene board, bidirectional high-strength steel wires which are inserted obliquely are distributed inside the polystyrene board, and a single side of the polystyrene board is covered by and welded with a steel wire mesh, accordingly, a heat-insulating plate with the whole welding steel wire frame is formed, wherein obliquely-inserted steel wires penetrate through the polystyrene board. The steel wire mesh is wrapped in a light composite concrete layer, the light composite concrete layer is combined with an extruded sheet through an interface agent to form the heat-insulating plate, an anchor bolt hole is arranged on the heat-insulating plate, a counter bored hole is arranged on the light composite concrete layer corresponding to the anchor bolt hole, an anchor bolt is arranged inside the anchor bolt hole, and one end of the anchor bolt extends out of the extruded sheet and the interface agent protective layer and is locked by a nut. The composite heat-insulating superimposed sheet is good in fire safety and capable of simplifying construction procedures, accelerating the construction progress, reducing building costs, achieving industrial production, guaranteeing the quality of all aspects and avoiding hidden quality dangers, such as empty drums, cracks, water seepage and falling-off, caused by complicated operating procedures to the maximum extent.

The present invention provides the preparation process of recombinant type I and II goose interferon. The preparation process includes: RT-PCR amplifying the gene coding goose IFN-alpha mature protein and IFN-gamma mature protein; sequencing identification of gene sequences, directionally sub-cloning target genes to pET30a prokaryotic expression vactor separately; inducing expressing in colibacillus BL21(DE3)plysS separately, separately performing affinity chromatographic purification of the fusion expressed target protein, separately directionally sub-cloning to pBlueBacHis2A and pMel BacA baculovirus transfer vector, separately cotransfecting insect cell Sf9 with the transfer vector and linearized baculovirus DNA, recombining virus infected insect cell, and expressing goose mIFN-alpha and mIFN-gamma in the prokaryotic expression vactor. The products may be used as goose antiviral vaccine medicine and immunity adjuvant.

The invention discloses amorphous selexipag, which is characterized in that the characteristic peak of the selexipag does not exist in an X-ray powder diffraction spectrum. The invention discloses a preparation method of the amorphous selexipag, a solid dispersoid of the amorphous selexipag and a pharmaceutic adjuvant and a preparation method of the solid dispersoid. The solid dispersoid is prepared from the selexipag and the pharmaceutic adjuvant; the weight ratio of the selexipag to the pharmaceutic adjuvant is 1 to (0.1 to 100), wherein the selexipag is in an amorphous state; the X-ray powder diffraction spectrum of the solid dispersoid has no characteristic peak of a crystal of the selexipag after the background peak of the pharmaceutic adjuvant is deducted. The solid dispersoid of the selexipag and the pharmaceutic adjuvant, which is provided by the invention, is favorable in stability and dispersity, is used for increasing the dissolution rate of the selexipag, is used for more beneficially improving the bioavailability of a medicinal preparation and the absorption of an organism to a medicine, and in an accelerated test condition, can be used for maintaining favorable physical stability and chemical stability. The preparation method of the amorphous solid dispersoid, which is provided by the invention, is simple to operate, low in cost, good in repeatability and easy to realize, and is suitable for industrialized production.

The invention discloses a synthesis method of AT-TBA, which comprises the following steps: sequentially BPTA, methanol, water and NaOH into a reaction vessel, stirring to react at 45-50 DEG C for 8-10 hours, adding activated carbon, stirring for 1-2 hours, filtering, cooling the filtrate to below 20 DEG C, regulating the pH value to 7, distilling under reduced pressure at 40-45 DEG C to recycle the methanol, dissolving the residual filtrate in water, regulating the pH value to 3, cooling to 5 DEG C, continuing stirring for 0.5-1 hour, carrying out vacuum filtration, sequentially washing the filter cake with water and acetonitrile, and carrying out vacuum drying on the filter cake to obtain a light yellow solid which is the AT-TBA. The synthesis method disclosed by the invention has the advantages of simple technique, easily controlled conditions and high yield, and can implement industrial production.

The invention discloses a rock wool composite thermal insulation plate integrated with main body structure concrete, which is characterized in that two faces of a rock wool plate are distributed with longitudinal steel wires and transversal steel wires, and connection points of the longitudinal steel wires and the transversal steel wires on both faces of the rock wool plate are connected through pulling wires which penetrate through the rock wool plate. The pulling wires and the connection points of the longitudinal steel wires and the transversal steel wires are connected through welding, the longitudinal steel wires and the transversal steel wires are distributed with fiberglass cloth, and thermal insulation mortar wraps the longitudinal steel wires, the transversal steel wires and the fiberglass cloth through adhesion agents to form a sealed thermal insulation mortar outer shell. The rock wool composite thermal insulation plate integrated with main body structure concrete has the advantages that firstly, good strength is provided during storage, construction and using processes, environmental pollution and occupational diseases are prevented during the construction process; secondly, a main body structure and a thermal insulation function are integrated, thereby simplifying construction procedures, improving construction process and lowering building cost; and thirdly, industrialized production is achieved, quality of all aspects is better guaranteed, and further potential quality hazard including hollowing, cracking, water seepage, falling-off and the like brought by complicated operation sequence are avoided to the largest extent.

The invention discloses an ultra-micro capsule material, a preparation method and application thereof. The ultra-micro capsule material is of a core-shell structure; the core-shell structure is composed of rare earth cobalt magnet R2Co17 micron-order particles which are adopted a core and protonated polypyrrole which is adopted as a shell. The preparation process of the ultra-micro capsule material includes the following steps that: a rare earth cobalt magnet R2Co17 block is ground and ball-milled, so that rare earth cobalt magnet R2Co17 micron-order particles can be obtained; the rare earth cobalt magnet R2Co17 micron-order particles are added into protonated pyrrole monomer; and an ammonium persulfate oxidizing agent is added into the protonated pyrrole monomer, and a newly obtained mixture is stirred, so that the ultra-micro capsule material can be obtained. The high-complex magnetic permeability rare earth cobalt magnet and the high-complex permittivity protonated polypyrrole are composited, so that the wave absorbing property of the ultra-micro capsule material in a microwave S-band can be effectively improved.

The invention provides a production method of fried bean sauce with three delicacies and shredded meat characterized in, using chicken stuffing or shredded chicken, minced mushroom, flour paste and salted and fermented soya paste as main ingredients, unfreezing the chicken stuffing or shredded chicken under atmospheric temperature, charging water-loss reducer, anti-oxidizing agent and anti-agglomeration agent, frying in laminated pan, charging soup stock and thickening agent.

The invention provides a preparation method of a tin selenide photovoltaic film, and belongs to the technical field of photovoltaic film preparation. The tin selenide photovoltaic film is obtained through the following steps that firstly a substrate is cleaned, then SnCl2.2H2O and SeO2 are put in a solvent, a precursor film is obtained on the substrate by using a spin coating method, the precursor film is dried and put in a closed container having hydrazine hydrate so that the precursor film sample is enabled not to be contacted with the hydrazine hydrate, the closed container in which the precursor film sample is arranged is heated, and the sample is taken out to be cooled and dried so that the tin selenide photovoltaic film can be obtained. The preparation method does not require the high temperature and high vacuum condition and has low requirement for instruments and equipment so that the production cost is low, the production efficiency is high and operation is easy. The obtained tin selenide photovoltaic film has great continuity and uniformity, and the new process is easy to control the component and the structure of the target product so that the low-cost and industrialized production method can be provided for preparing the high-performance tin selenide photovoltaic film.

The invention relates to a manufacture device and method for a large-size fine-grain homogeneous aluminum alloy cast ingot, belonging to the field of metal material machinery. The device mainly comprises a uniform cooler, a thermal ejector, an electromagnetic stirrer, a crystallizer and a dummy ingot, wherein the thermal ejector is arranged above the crystallizer; the electromagnetic stirrer is arranged on the periphery of the thermal ejector and the crystallizer; the dummy ingot is arranged below the crystallizer; the uniform cooler is arranged in the crystallizer; and the uniform cooler consists of an inner pipe and an outer pipe. According to the manufacture device and method, through special coupling treatment of uniform cooling in the crystallizer and electromagnetic stirring outside the crystallizer is applied to an alloy melt, so that effective control on uniformity of a temperature field and a component field of the large-size alloy melt is realized, and the large-size aluminum alloy cast ingot with uniform and fine structure and uniform components is manufactured. The manufacture device is simple in structure, feasible in method, obvious in effect, high in production efficiency and easy for combination with large-scale industrial production, and has a wide industrial application prospect in the fields of aerospace, rail transportation and manufacture of ships and the like.

The invention relates to a method for preparing a copper-aluminum-sulfur film, and belongs to the technical field of preparation of photoelectric films. The method comprises the following steps of: firstly cleaning a glass substrate; then placing CuCl2.2H2O, Al(NO3)3.9H2O and CH4N2S into a solvent, and applying a spincoating method to obtain a precursor film on the glass substrate; drying the precursor, and placing the precursor into a closable container filled with hydrazine hydrate, wherein a precursor film sample is not contacted with the hydrazine hydrate; heating the closable container, then taking out a sample, and drying the sample to obtain the copper-aluminum-sulfur photoelectric film. The method disclosed by the invention has the advantages of no need of high-temperature vacuum condition, low requirement on equipment and instruments, easiness for operation, low production cost, high production efficiency, and the like. The obtained copper-aluminum-sulfur photoelectric film has the advantages of preferred orientation growth and better continuity and uniformity. The new process provides the production method which is low in cost and can realize industrialization for preparing the high-property copper-aluminum-sulfur photoelectric film.

The invention discloses solid dispersoid of amorphous lesinurad and a pharmaceutic adjuvant and a preparation method of the solid dispersoid. The solid dispersoid is prepared from the lesinurad and the pharmaceutic adjuvant; the weight ratio of the lesinurad to the pharmaceutic adjuvant is 1 to (0.1 to 100), wherein the lesinurad is in an amorphous state; the X-ray powder diffraction spectrum of the solid dispersoid has no the characteristic peak of a crystal of the lesinurad after the background peak of the pharmaceutic adjuvant is deducted. The solid dispersoid of the amorphous lesinurad and the pharmaceutic adjuvant, which is provided by the invention, is favorable in stability and dispersity, is used for increasing the dissolution rate of the lesinurad, is used for more beneficially improving the bioavailability of a medicinal preparation and the absorption of an organism to a medicine, and in an accelerated test condition, can be used for maintaining favorable physical stability and chemical stability. The preparation method of the amorphous solid dispersoid, which is provided by the invention, is simple to operate, low in cost, good in repeatability and easy to realize, and is suitable for industrialized production.

The invention provides a pharmaceutical composition containing amorphous vortioxetine hydrobromide and a preparation method thereof. The pharmaceutical composition comprises vortioxetine hydrobromide,at least one organic carrier and at least one adsorbent, wherein a weight ratio of vortioxetine hydrobromide to all the organic carriers is 1: 0.1-10, and a weight ratio of vortioxetine hydrobromideto all the adsorbents is 1: 0.1-10; vortioxetine hydrobromide in the composition is in an amorphous state; and after deduction of the background peaks of pharmaceutical adjuvants, the X-ray powder diffraction spectrum of the composition is free of characteristic peaks of the crystal of vortioxetine hydrobromide. The composition of vortioxetine hydrobromide and the pharmaceutical adjuvants has goodstability and dispersibility; the dissolution rate of vortioxetine hydrobromide is improved; the bioavailability of a medicinal preparation and body absorption of vortioxetine hydrobromide are improved; and under accelerated test conditions, the composition can maintain good physical stability and chemical stability. The preparation method for the amorphous composition of the invention has the advantages of simple operation, low cost, good reproducibility, easy realization and suitability for industrialized production.

The invention relates to a method for preparing a copper-aluminum-sulfur film, and belongs to the technical field of preparation of photoelectric films. The method comprises the following steps of: firstly cleaning a substrate; then placing CuCl2.2H2O and Al(NO3)3.9H2O into a solvent, and applying a spincoating method to obtain a precursor film on the substrate; drying the precursor film, and placing the precursor film into a closable container filled with hydrazine hydrate and sublimed sulfur, wherein a precursor film sample is not contacted with the hydrazine hydrate and the sublimed sulfur; finally drying the sample to obtain the copper-aluminum-sulfur photoelectric film. The method disclosed by the invention has the advantages of no need of high-temperature high-vacuum condition, low requirement on instruments and equipment, low production cost, high production efficiency and easiness for operation. The obtained copper-aluminum-sulfur photoelectric film has better continuity and uniformity. The new process can be used for easily controlling the components and structure of a target product and provides the preparation method which is low in cost and can realize industrialization for preparing the high-property copper-aluminum-sulfur photoelectric film.

The invention relates to midostaurin novel crystal forms A, B and C as well as a preparation method and application of the novel crystal forms A, B and C. The crystal forms have excellent properties in the aspects of physical and chemical stability and processing adaptability. The crystallization process is simple and convenient to operate, and industrial production can be realized.

The invention relates to novel crystal forms A, B, C and D of clorsulon as well as preparation methods and applications of the crystal forms. The crystal forms have excellent properties in physical and chemical stability and processing adaptability.

The invention discloses a carvacrol solid lipid nanoparticles dispersion liquid with bacteriostatic activity, a preparation method and application thereof. The carvacrol solid lipid nanoparticles include: carvacrol 0.05-0.5wt%, glycerol monostearate 0.5-1wt%, 1, 2-propylene glycol ester 0.5-1wt%, Twain-80 1-2wt%, ethyl alcohol 5-6wt%, and the remainder is water. The effective component of the carvacrol solid lipid nanoparticles dispersion liquid is derived from the plant extract, which is green, environmentally friendly and harmless to human body. The solid lipid nanoparticles improve the water dispersibility of carvacrol effectively, increase the solubility of carvacrol in water, and improve the stability of carvacrol.

The present invention provides a recombinant prokaryotic expression protein antigen for detecting autochthonous trichinella spiralis antibody and its preparation method. Said product can be used as detection antigen of indirect-ELISA and Dot-ELISA method for detecting autochthonous trichinella spiralis antibody, also can be used as gene engineering subunit vaccine for preventing autochthonous trichinella spiralis infection. The preparation process of said product includes the following steps: (1) designing specific primer for amplifying TNPG gene; (2), utilizing PCR amplification to obtain TNPG gene segment; (3), cloning TNPG gene and sequencing, and making identification; (4), directionally subcloning TNPG gene to pET-3a prokaryotic expression vector; (5), induced expression of TNPG gene in colibacillus; and (6), affinity chromatography purification of TNPG gene expression protein.

A method for synthesizing bilastine intermediates, including: S1, Friedel-Crafts reaction of phenethyl acetate with isobutyryl halide under the catalysis of Lewis acid to generate intermediate compound B; S2, intermediate compound B in alkaline Or hydrolytically remove the ester group under acidic conditions to obtain intermediate compound C; S3, intermediate compound C is subjected to hydroxyl protection reaction to benzyl or methoxybenzyl protecting group to obtain intermediate compound D; S4, intermediate compound D is bromine The bromo group generates intermediate compound E in the substitution reaction; S5, intermediate compound E undergoes a rearrangement reaction under the catalysis of a metal reagent to generate intermediate compound F; S6, intermediate compound F is hydrogenated or oxidatively deprotected to generate the target compound Bilas Stinging intermediate α,α-dimethyl-4-(2-hydroxyethyl)phenylacetic acid methyl ester. The method of the invention has low raw material cost, simple requirements for equipment and experimental conditions, can realize industrial production, and has high application value.

The invention discloses wear-resistant impact-resistant waterborne epoxy floor paint and a preparation method thereof. The preparation method comprises the following steps: S1, preparing an allyltriphenylphosphonium bromide / graphene oxide compound; s2, preparing a quaternary ammonium salt polymer intermediate; and S3, preparing the wear-resistant impact-resistant waterborne epoxy floor paint. According to the invention, allyltriphenylphosphonium bromide is introduced into a graphene oxide sheet layer, and an allyltriphenylphosphonium bromide molecular chain can be utilized to expand the sheet layer structure of the graphene oxide, so that the interface bonding force between the allyltriphenylphosphonium bromide / graphene oxide compound and an epoxy floor paint system is increased; the wear resistance and the impact resistance of the epoxy floor are optimized; and the special phenylphosphine structure of the allyl triphenyl phosphonium bromide has high thermal stability, so that the weather resistance of the epoxy floor paint can be greatly improved, the aging of the epoxy floor paint is prevented, and the service life of the epoxy floor paint is greatly prolonged.

The invention relates to a preparation method of an opaque glaze. Firstly, the molar number of all alkaline oxides in the formula of the opaque glaze is determined, and then the molar ratio of silicon oxide in the formula is controlled to be 3.00-4.50 and the molar ratio of aluminium oxide in the formula is controlled to be 0.30-0.40, thus the glaze is opacified in an opacifying area to form the opaque glaze. The raw materials adopted by the preparation method are low in cost, the preparation process is simple and is easy to control, and the opaque glaze is high in brightness, thus the preparation method has a wide application prospect.

The invention discloses a method for preparing a copper tin sulfur film with preferred orientation, belonging to the technical field of photoelectric film preparation. The method comprises the following steps of: firstly, washing a glass substrate, then putting CuCl2.2H2O, SnCl2.2H2O and thiourea into a solvent, and adjusting a pH value; obtaining a precursor film on the glass substrate with a spin coating method, baking and putting the precursor film into a sealed container with hydration hydrazine to ensure that the precursor film is not in contact with the hydrazine; the sealed container with precursor film samples is heated, and finally drying to obtain a copper tin sulfur photoelectric film. The method has the advantages of no need of the conditions of high temperature and high vacuum, low requirements for instruments and equipment, low production cost, production efficiency, and easiness in operation. The obtained copper tin sulfur photoelectric film grows in a preferred orientation mode and has good continuity and uniformity. The novel process provides a low-cost production method which can realize industrialization production for preparing high-performance copper tin sulfur photoelectric films.

The present invention provides a recombinant prokaryotic expression protein antigen for detecting autochthonous trichinella spiralis antibody and its preparation method. Said product can be used as detection antigen of indirect-ELISA and Dot-ELISA method for detecting autochthonous trichinella spiralis antibody, also can be used as gene engineering subunit vaccine for preventing autochthonous trichinella spiralis infection. The preparation process of said product includes the following steps: (1) designing specific primer for amplifying TNPG gene; (2), utilizing PCR amplification to obtain TNPG gene segment; (3), cloning TNPG gene and sequencing, and making identification; (4), directionally subcloning TNPG gene to pET-3a prokaryotic expression vector; (5), induced expression of TNPG gene in colibacillus; and (6), affinity chromatography purification of TNPG gene expression protein.

The invention discloses a dinosaur fossil anti-weathering material and a preparation method thereof. The method comprises the steps that a methyltriethoxy organic silicon resin ethanol emulsion with the mass concentration ranging from 30% to 50% is prepared; octamethylcyclotetrasiloxane modified nano-silicon dioxide and a dispersing agent special for nano-silicon dioxide are added, ultrasonic treatment is conducted, and a methyltriethoxy organic silicon resin composite emulsion doped with modified nano-silicon dioxide, namely, the dinosaur fossil anti-weathering material is obtained. The dinosaur fossil anti-weathering material is waterborne composite paint which is convenient to construct, low in cost, poisonless and environmentally friendly and has the advantages of being good in chemical stability and film-forming property; the formed film has the advantages of being good in acid and alkali corrosion resistance and ultraviolet aging resistance, high in adhesion, good in thermal stability, good in light transmission and the like, can maintain the original appearance of a dinosaur fossil, better improve the anti-weathering capacity of the dinosaur fossil and prolong the life of the dinosaur fossil and can have a good fixing effect on surrounding rocks on the periphery of the dinosaur fossil.