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Method and device for constructing human auricular cartilage in vitro

A technology of auricle and cartilage, applied in the field of biomedical engineering, can solve problems such as the inability to realize the construction of human auricle cartilage, the inability to reach clinical transplantation, and the easy formation of hollow human auricle cartilage tissue.

Active Publication Date: 2013-02-06
HANGZHOU BAIQIAO MEDICAL TECH CO LTD
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  • Abstract
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Problems solved by technology

[0002] When the tissue engineering method is used to combine cells and biodegradable materials to construct tissue-engineered human auricle cartilage, the shape of the human auricle constructed in vitro is far from that of a normal person, and the internal tissue of the human auricle cartilage is easy to form a hollow, etc. Defects, the mechanical properties are far from normal human auricular cartilage, and cannot meet the requirements of clinical transplantation
The current method of cultivating the human auricle is manual plasticity and static culture in vitro, which can only construct a small-scale human auricle model, and cannot realize the normal construction of normal human auricle cartilage

Method used

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  • Method and device for constructing human auricular cartilage in vitro
  • Method and device for constructing human auricular cartilage in vitro
  • Method and device for constructing human auricular cartilage in vitro

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Embodiment Construction

[0027] The present invention will be further described below in conjunction with accompanying drawing.

[0028] Such as figure 1 , a bioreactor for dynamic culture of human auricle cartilage based on compressive stress and perfusion includes five parts: a cam rotation mechanism, a moving guide mechanism, a displacement adjustment mechanism, a human auricle cartilage culture mechanism and a positioning connection mechanism.

[0029] The cam rotation mechanism comprises: coupling shaft 13, left bearing support seat 27, bearing baffle plate 11, bearing 12, bearing baffle plate fixing screw 14, rotating shaft 29, cam 28, right bearing support seat 10. The shaft coupling 13 is connected with the rotating shaft 29, and the rotating shaft is fixed in the left and right bearings 12, and the bearings are fixed on the left and right bearing supports (27, 10), fixed and positioned by the bearing baffle 11 and the fixing screw 14, The cam 28 is placed at the center of the rotating shaft...

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Abstract

The invention relates to a method and device for constructing the human auricular cartilage in vitro. At present, the human auricular cartilage is statically cultured in vitro by adopting manual plasticity, only an auricular cartilage model of small scale is constructed and the normal human auricular cartilage can not be constructed. The device comprises an auricular cartilage bioreactor, a control unit and a measurement unit, wherein the human auricular cartilage bioreactor comprises a cam rotating mechanism, a movable guide mechanism, a displacement regulation mechanism, an auricular cartilage culture mechanism and a positioning linking mechanism; the control unit comprises a touch screen, a programmable controller, a motor and a speed regulator; and the measurement unit comprises a pressure sensor, a flow sensor, a data acquisition card and measurement software. The invention realizes fully-automatic dynamic culture of the human auricular cartilage by adopting a pressure stress and perfusion way; and the human auricular cartilage bioreactor can be massively cultured and constructed in a manner of combining one device into multiple heads, and previous manual operation and static culture modes are completely changed.

Description

technical field [0001] The patent of the invention belongs to the field of biomedical engineering, and relates to a method and device for dynamically culturing human auricles in vitro, in particular to a method and device for compounding seed cells with biodegradable materials and perfusing them in dynamic environments of different frequencies and compressive stresses. A culture device for human auricle with cell viability, good human auricle morphology and certain mechanical strength. It is suitable for constructing human auricular cartilage with good shape in vitro in the field of biomedical engineering. Background technique [0002] When the tissue engineering method is used to combine cells and biodegradable materials to construct tissue-engineered human auricle cartilage, the shape of the human auricle constructed in vitro is far from that of a normal person, and the internal tissue of the human auricle cartilage is easy to form a hollow, etc. Compared with normal huma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/28
Inventor 李宏厉力华吴开华徐铭恩高力应南娇
Owner HANGZHOU BAIQIAO MEDICAL TECH CO LTD
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