Application of gambogic acid in preparing inflammation inhibitor

A technology of inflammation inhibitor, gambogic acid, applied in the field of gambogic acid, can solve the problems of unreported anti-inflammatory physiological activity and so on
CN102198127AInactive Publication Date: 2011-09-28XIAMEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
XIAMEN UNIV
Publication Date
2011-09-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an application of gambogic acid in preparing an inflammation inhibitor, in particular to an application of the gambogic acid in preparing medicaments for treating inflammatory factor mediated inflammatory diseases such as endotoxin shock and the like. The gambogic acid has a chemical formula of C38H44O8 and a molecular weight of 628.75, and can be used for preparing the medicaments for treating the inflammatory factor mediated inflammatory diseases such as endotoxin shock and the like, wherein the inflammatory diseases comprise rheumatic arthritis, inflammatory bowel disease, neurodegenerative disease, septic shock and the like. Approved by pharmacological experiments, the gambogic acid can effectively inhibit inflammatory factors such as tumor necrosis factor (TNFalpha), interleukin 6 (IL-6) and nitric oxide (NO), and can be used as an inflammation inhibitor for preparing the medicaments for treating the inflammatory factor mediated inflammatory diseases such as rheumatic arthritis, inflammatory bowel disease, neurodegenerative disease, septic shock and the like.
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Description

technical field

[0001] The present invention relates to a gambogic acid (Gambogic acid, abbreviated as GBA), in particular to the application of gambogic acid in the preparation of inflammation inhibitors. Background technique

[0002] Inflammatory response is one of the important components of the body's immune system, which is precisely regulated by the body through various channels. However, when the inflammatory response is uncontrollable, it will lead to various diseases in the body, such as rheumatoid arthritis (rtheumatoid arthritis), inflammatory bowel disease (Inflammatory bowel disease, IBD), neurodegenerative disease (neurodegenerative disorder) and septic shock (septic shock syndrome) and so on, long-term inflammatory response stimulation can also induce body canceration, which seriously threaten people's physical and mental health (1, Monaco, et al., Curr Drug Targets Inflamm Allergy, 2004, 3, 35-42 ; 2, Schwartsburd et al., Cancer Metastasis Rev, 2003, 22, 95-...

Claims

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