Manufacturing method of superparamagnetic magnesium-doped ferrite nanoparticles and the nanoparticles

A nanoparticle and magnesium ferrite technology, applied in nanostructure manufacturing, in vivo test preparations, nanomagnetism, etc., can solve problems such as insufficient research, and achieve the effect of improving effective imaging diagnostic technology

Inactive Publication Date: 2011-11-30
NURI VISTA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

According to recent reports, due to the high magnetic susceptibility, high self-heating (~120°C) and high biocompatibility (cell survival rate of 90%) of several magnesium-based alloys or oxide nanoparticles with a size of several nm to several μm, Therefore, the possibility of being used as a hyperthermia agent is very high, but the research related to nanoparticles with a size below 10nm that can actually be injected into the human body is not sufficient, and it has not been applied to hyperthermia agents (hyperthermia agent) and Heat shock protein derivatives and the application technology for clinical treatment of brain tumors, optic nerve diseases, cranial nerve diseases and other diseases

Method used

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  • Manufacturing method of superparamagnetic magnesium-doped ferrite nanoparticles and the nanoparticles
  • Manufacturing method of superparamagnetic magnesium-doped ferrite nanoparticles and the nanoparticles
  • Manufacturing method of superparamagnetic magnesium-doped ferrite nanoparticles and the nanoparticles

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Embodiment Construction

[0022] Such as figure 1 Shown, the manufacture method of the superparamagnetic magnesium-doped ferrite nano-particle of processing of the present invention, comprises the steps: in raw material triacetylacetonate iron (Fe (III) acetylacetonate), magnesium and reducing agent (reduction, hexadecanediol, After mixing benzyl ether (Benzyl ether) and oleic acid (Oleic acid) and oleylamine (Oleylamine) as surfactants in hexadecanediol), nucleation is generated by the first heat treatment, and the nanometer is made by the second heat treatment. After the particles are grown, they are washed, centrifuged, dried and ground.

[0023] Nanoparticles manufactured through the above series of processes were additionally coated with Tetraethylorthosilicate, chitosan, and D-glucose dextran.

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Abstract

The present invention relates to a manufacturing method of engineered Mg doped ferrite superparamagnetic nanoparticles processed by doping magnesium and the technology of applying it to hyperthermia and heat shock protein derivation of self-defense mechanism .

Description

technical field [0001] The invention relates to a method for manufacturing superparamagnetic magnesium-doped ferrite (Mg doped ferrite) nanoparticles capable of processing high-temperature self-heating and an application thereof. The processed superparamagnetic Mg-doped ferrite nanoparticles manufactured according to the present invention can be applied to hyperthermia agents and self-defense mechanism heat shock protein derivatives against cancer in vivo, and thus can be applied to brain Clinical treatment of various diseases such as tumors, optic nerve diseases, and cranial nerve diseases. Background technique [0002] Hyperthermia is a treatment method that heats cancer cells at a temperature of 43°C to 45°C to cause apoptosis. While minimizing side effects, it is possible to selectively and effectively treat cancer cells (tissues) distributed locally or deeply in the human body, and the scope of research on its clinical feasibility is rapidly expanding. [0003] Especi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B82B3/00C01G49/00
CPCC01P2004/04C01P2002/72B82Y30/00B82Y5/00A61K49/183C01P2004/64C01G49/0036C01P2006/42A61K49/1863A61K41/0052B82Y25/00A61P25/00A61P27/02A61P27/06A61P35/00B82B3/00C01G49/00B82Y40/00
Inventor 裴成泰郑景元
Owner NURI VISTA
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