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Method used to estimate viscosity

A viscosity and liquid technology, applied in the analysis of materials, measurement of DC flow characteristics, instruments, etc.

Inactive Publication Date: 2011-12-21
ORTHO-CLINICAL DIAGNOSTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Known viscosity estimation techniques for metering systems in known diagnostic analyzers are generally only suitable for aspirated volumes greater than 35 μL

Method used

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Embodiment Construction

[0021] While the various applications of viscosity estimation according to the present invention are not limited, a particularly useful application is in the field of diagnostic analysis. The range of analyzers and methods that can be used with the present invention is wide and is discussed in more detail below.

[0022] As used herein, a "small volume" or "smaller volume" of liquid is defined as generally < 35 μL, < 25 μL, < 20 μL, < 10 μL, < 5 μL, and even less than 2 μL, and in particular a volume of ≤ 20 μL.

[0023] In the following description of preferred embodiments of the invention, a piston pump is described, however, other pumping mechanisms such as diaphragm pumps may also be used with the invention.

[0024] While not wishing to be bound by any theory, the present invention is based on the inventor's discovery that estimated viscosity is determined from pressure measurements alone. Through one or more of the following derivations, the inventors were able to show ...

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Abstract

The present invention provides a method for estimating the viscosity of a liquid in an aspiration or dispensing probe, the method comprising: measuring a reference pressure (Pref), which is the pressure inside the metering tip when no dispensing or aspiration is in progress ; Dispense or aspirate liquid with a volume of air between said liquid and the pumping mechanism of the probe; Stop aspiration or dispensing; Measure the pressure inside the tip (Pstop) at time (t), time (t ) is the time at which aspiration or dispensing stops; the pressure inside the tip (Pstop') is measured at time (t') after time t; and the viscosity is estimated from Pref, Pstop, and Pstop'. In a preferred embodiment, the method is performed on a diagnostic analyzer.

Description

Background technique [0001] The present invention relates to estimating the viscosity of a liquid in a metering system, such as a liquid delivered by a metering system on a diagnostic analyzer. In particular, the present invention relates to estimating viscosity by more accurately determining the amount of fluid aspirated or dispensed from selected pressure measurements. [0002] There is a trend in the field of diagnostics to use less and less volumes of liquid when performing diagnostic analyzes or assays, for example on diagnostic analyzers. Therefore, precise and accurate handling of small volumes (eg, microliters) of fluid is critical to the effectiveness of the assay being performed. The performance of available liquid metering systems, such as those found on diagnostic analyzers, is sensitive to liquid properties such as viscosity, in part because higher viscosity liquids are more likely to adhere to the surface of suction probes or such probes the metering tip, and a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N11/08
CPCG01N35/1002G01N11/08G01N35/1009
Inventor Z·丁
Owner ORTHO-CLINICAL DIAGNOSTICS