Antimicrobial foamable soaps

A technology of antimicrobial and foaming compositions, applied in biocides, antibacterial drugs, drug combinations, etc.

Inactive Publication Date: 2012-01-11
OHSO CLEAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Other synthetic and semisynthetic antibiotics (eg, vancomycin and oxazolidines) are currently effective in the treatment of MRSA, but resistance to these agents has also been reported

Method used

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  • Antimicrobial foamable soaps
  • Antimicrobial foamable soaps
  • Antimicrobial foamable soaps

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] The time of embodiment 1.CA-MRSA kills the test experiment

[0093] Under the conditions of this study, the foamable composition of Formulation 1 showed a 99.9% reduction in surviving community-acquired methicillin-resistant Staphylococcus aureus-CA-MRSA (NRS384) (Genotype USA300) after 15 seconds of exposure (3.735Log 10 ), a 99.999% reduction (5.2Log 10 ), which was reduced by more than 99.999% (>5.8Log 10 ), which was reduced by more than 99.999% (>5.8Log 10 ), which was reduced by more than 99.999% (>5.8Log 10 ), were tested at room temperature (21°C).

[0094] Table 2. Test Results

[0095]

[0096] Values ​​<1 were utilized for computational reasons only.

[0097] Table 3. Calculated data

[0098]

[0099] * Colony forming units per mL of test mixture

Embodiment 2

[0100] The time killing test test of embodiment 2.MRSA

[0101] Under the conditions of this study, the foamable composition of Formulation 1 showed a 99.99% reduction (4.32 Log 10 ), a 99.999% reduction (5.5Log 10 ), which was reduced by more than 99.999% (>5.8Log 10 ), which was reduced by more than 99.999% (>5.8Log 10 ), were tested at room temperature (20°C).

[0102] Table 4. Test Results

[0103]

[0104] The use of values ​​<1 in place of 0 is for computational reasons only.

[0105] Table 5. Calculated data

[0106]

[0107] * Colony forming units per mL of test mixture

Embodiment 3

[0108] The time killing test test of embodiment 3.MRSA

[0109] Under the conditions of this study, the foamable composition of Formulation 3 showed a 99.99% reduction (4.84 Log 10 ), which was reduced by more than 99.999% (>5.8Log 10 ), which was reduced by more than 99.999% (>5.8Log 10 ), which was reduced by more than 99.999% (>5.8Log 10 ), were tested at room temperature (20°C).

[0110] Table 6. Test Results

[0111]

[0112] Values ​​< 1 are used instead of 0 for computational reasons only.

[0113] Table 7. Calculated data

[0114]

[0115] * Colony forming units per mL of test mixture

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PUM

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Abstract

Environmentally-friendly, natural essential oil based foamable compositions can be used as antimicrobial substances. The foamable compositions contain thyme oil as the sole or principal antimicrobial agent. The foamable compositions are topically applied and may be used as a preventative and / or a therapeutic. The antimicrobial foamable compositions are highly efficacious against methicillin-resistant Staphylococcus aureus (MRSA).

Description

[0001] Cross References to Related Applications [0002] This application claims priority under 35 U.S.C. §119(e) to U.S. Provisional Application 61 / 109,721, filed October 30, 2008, which is hereby incorporated by reference in its entirety. field of invention [0003] The present invention generally relates to antimicrobial foamable compositions for the treatment and prevention of skin infections. More specifically, the present invention relates to topical antimicrobial foamable compositions containing thyme oil for the treatment and prevention of bacterial and drug-resistant bacterial infections, such as methicillin-resistant Staphylococcus aureus ) (MRSA). Background of the invention [0004] Staphylococcus aureus, often referred to simply as "Staph," is a strain of bacteria that is prevalent on the skin or in the nasal passages of about one-third of the population. Staph infections are the most common cause of skin infections in the United States. Most staph infections...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11D9/50C11D17/00
CPCA61K8/463A61K38/06A61K8/19C11D3/046A61Q17/005A61K8/64C11D3/382A01N65/22C11D3/168A61K36/53C11D3/48A61K31/305A01N59/20A61Q19/10A61K31/30A61K8/604A61K8/922A61K31/05A61P17/02A61P31/04A01N31/08A01N65/00A01N2300/00A61K2300/00C11D9/005C11D9/38C11D17/00
Inventor M·D·L·韦斯
Owner OHSO CLEAN
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