Three-mode small animal imaging system integrating fluorescence, nuclei and X rays

Abstract

The invention relates to a three-mode small animal imaging system integrating fluorescence, nuclei and X rays, which is characterized in that the system comprises a machine body, a support frame is arranged in the machine body, and a fluorescence imaging system, a nuclei imaging system and an X ray imaging system are respectively fixed on the support frame; the fluorescence imaging system and thenuclei imaging system are arranged on the inner side of the machine body and form orthogonal in geometry, and the X ray imaging system is arranged at an inlet side of the machine body side by side with the fluorescence imaging system and the nuclei imaging system; the fluorescence imaging system comprises an excitation light source board, and a CCD (Charge Coupled Device) camera is arranged abovethe excitation light source board; the nuclei imaging system comprises two PET (Positron Emission Tomography) detectors which are arranged at the two sides of the excitation light source board in parallel at intervals; and the X ray imaging system comprises a horizontal flat panel detector, and an X ray spherical tube is arranged above the flat panel detector. A new measure and a new tool are provided for modern biological and medical research, and the system can be widely used in modern biological and medical research.

Description

Technical field [0001] The invention relates to an imaging system, in particular to a small animal imaging system which is used for modern biology and medical research, which integrates fluorescence, nuclide and X-ray three modalities. Background technique [0002] Molecular imaging technology can provide visualization methods for observing cells, molecular events and their dynamic processes. It has become an important tool in the fields of biology, medicine, and new drug development. Small animal bodies are the main experimental methods in modern biology and medical research. Therefore, small animal body image detection has become a hot spot in molecular imaging research. Excitation fluorescence tomography (FMT) is an optical molecular imaging technology that can perform quantitative analysis in living organisms. The application of molecular-specific fluorescent probes to in vivo detection can achieve non-invasive and visual biological, chemical and physical behavior. Positron...

AI Technical Summary

Problems solved by technology

Most of the existing technologies are dual-mode imaging systems, such as the combination of nuclide and fluorescence, CT and PET, and CT and fluorescence. resolution requirements, and the existing fluorescence and nuclide imaging systems generally achieve 360° data acquisition by rotating the animal body or rotating the imaging system frame. Due to the long acquisition time of a single image data, it is not conducive to observation Rapid dynamic changes of cellular and molecular events

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