Decoquinate solution and preparation method thereof

A kind of decoquinate, the technology of decoquinate, applied in decoquinate solution and preparation field thereof

Inactive Publication Date: 2012-04-11
上海恒丰强生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] An object of the present invention is to provide decoquinate solution, to overcome the defects of existing decoquinate dosage forms

Method used

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  • Decoquinate solution and preparation method thereof
  • Decoquinate solution and preparation method thereof
  • Decoquinate solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The decoquinate solution, calculated by weight percentage, is mainly composed of decoquinate as the main material, and is prepared with an appropriate amount of polyethylene glycol and dimethylformamide.

[0022] Recipe and method:

[0023] Decoquinate 5%

[0024] Polyethylene Glycol 75%

[0025] Dimethylformamide 20%.

[0026] production method

[0027] (1) In the preparation in advance, the decoquinate weighed as required is dissolved with an appropriate amount of dimethylformamide for subsequent use;

[0028] (2) Add polyethylene glycol to the full amount, continue to stir to make it evenly mixed, stir the liquid medicine evenly under the condition of stirring, and then test it;

[0029] (3) After passing the inspection, it is filled and sealed under the condition of stirring, and then labeled, packaged, randomly inspected, and put into storage.

Embodiment 2

[0031] Study data and results of stability experiments, accelerated and long-term experiments.

[0032] accelerated test

[0033] Take this product, imitate the marketing package, put it in a desiccator filled with saturated sodium chloride solution (RH 75%±5%), and then place it in a constant temperature box with a temperature of 40°C±2°C. , Sampling in March and June to investigate the appearance, color, content, clarity, related substances, insoluble particles, sterility and bacterial endotoxin of the samples.

[0034] The results are shown in Table 1.

[0035] Table 1. Accelerated test results (temperature 40±2°C, relative humidity 75%±5%)

[0036]

[0037]

[0038]

[0039]

[0040] test results

[0041] Show according to table 1, decoquinate solution accelerated test 6 months, every index has no significant change.

[0042] summary

[0043] The accelerated test results show that the specification is 100mL: 5g decoquinate solution, packaged as a simulated...

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PUM

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Abstract

The invention discloses a decoquinate solution which comprises the following raw materials by weight: 5% of decoquinate, 75% of alcoholic solvents, 20% of dimethyl formamide. The invention also discloses a preparation method of the decoquinate solution. With the mode that decoquinate is dissolved in organic solvents, the decoquinate is in a solution form, and is administrated in an oral liquid form. Decoquinate is highly liposoluble, is difficult to dissolve in water and common organic solvents, has a low premix dissolution rate, and low bioavailability; when decoquinate is developed into a solvent through a pharmaceutical method, the administration is convenient, and the bioavailability is high.

Description

technical field [0001] The invention relates to a decoquinate solution and a preparation method thereof. Background technique [0002] Decoxyquinate (English name: decoquinate; Deccox, chemical name: 6-decyloxy-7-ethoxy-4-hydroxy-3-quinolinecarboxylic acid ethyl ester), is an anticoccidial drug of quinolines , is effective against a variety of Eimeria coccidia, and is used to prevent chicken coccidiosis caused by various coccidiosis. Decoxyquinate plays a role in the asexual reproduction stage of coccidia. After entering the sporozoite cell, it prevents its development by interfering with DNA synthesis. It starts to play a role in the early life cycle of coccidia, so as to avoid damage to poultry intestinal tract, and can more effectively help farmers obtain higher economic benefits. Compared with maduramycin, the results show that the anti-coccidia If the index is greater than 180, decoquinate anticoccidial is a high-efficiency drug. No coccidia oocysts were detected in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/47A61K47/18A61P33/02
Inventor 郭春艳李敏高建辉廖洪
Owner 上海恒丰强生物技术有限公司
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