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Amlodipine, aliskiren and pril compound antihypertensive medicament

A technology of amlodipine and drugs, applied in the field of antihypertensive drugs, which can solve the problems of lowering and lowering curative effect

Inactive Publication Date: 2012-05-02
邬林祥 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, reduce the curative effect that may be caused by long-term application of puril

Method used

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  • Amlodipine, aliskiren and pril compound antihypertensive medicament
  • Amlodipine, aliskiren and pril compound antihypertensive medicament
  • Amlodipine, aliskiren and pril compound antihypertensive medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Preparation of Aliskiren, Amlodipine and Enalapril Fixed Prescription Tablets

[0017]

[0018]

[0019] The preparation method is

[0020] 1. Pass Aliskiren, Amlodipine, and Enalapril (hereinafter referred to as main ingredients) respectively through a 100-mesh sieve and mix them evenly in a mixer.

[0021] 2. Put the starch, powdered sugar and dextrin through a 100-mesh sieve and put them into the mixer once to mix evenly, then add the mixed main ingredients and mix evenly, and add an appropriate amount of 70% ethanol to make a soft material.

[0022] 3. Granulate through a 20-mesh sieve.

[0023] 4. Dry the granules in a fluidized bed.

[0024] 5. The dried granules are sized through a 18-mesh sieve.

[0025] 6. Put the whole granules into the mixer, put in magnesium stearate and mix well.

[0026] 7. Tablet into 1,000,000 pieces.

Embodiment 2

[0028] Preparation of Aliskiren, Amlodipine and Enalapril Fixed Formula Capsules

[0029]

[0030]

[0031] The preparation method is

[0032] 1. Pass Aliskiren, Amlodipine, and Enalapril (hereinafter referred to as main ingredients) respectively through a 100-mesh sieve and mix them evenly in a mixer.

[0033] 2. Put the starch, powdered sugar and dextrin through a 100-mesh sieve and put them into the mixer once to mix evenly, then add the mixed main ingredients and mix evenly, and add an appropriate amount of 70% ethanol to make a soft material.

[0034] 3. Granulate through a 20-mesh sieve.

[0035] 4. Dry the granules in a fluidized bed.

[0036] 5. The dried granules are sized through a 18-mesh sieve.

[0037] 6. Put the prepared granules in the capsule filling machine for capsule preparation

[0038] 7. Make 1,000,000 pieces.

Embodiment 3

[0040] Preparation of Aliskiren, Amlodipine and Enalapril Fixed Formula Powder

[0041]

[0042] The preparation method is

[0043] 1. Pass Aliskiren, Amlodipine, and Enalapril (hereinafter referred to as main ingredients) respectively through a 100-mesh sieve and mix them evenly in a mixer.

[0044] 2. Make 1,000,000 packs after dividing doses.

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PUM

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Abstract

The invention relates to an amlodipine, aliskiren and pril compound antihypertensive medicament, wherein effective components of the medicament comprise aliskiren or medical salt thereof, amlodipine or medical salt thereof and pril or medical salt in a weight ratio of (10-500):1:(2.5-100), preferably (15-120):1:(5-32), and more preferably 30:1:5. The medicinal composition has excellent antihypertensive effect, and has remarkably reduced toxic and side effects.

Description

technical field [0001] The invention relates to the technical field of antihypertensive drugs, in particular to compound antihypertensive drugs such as amlodipine, alikran and puril, which have antihypertensive effects. Background technique [0002] Hypertension is a clinical syndrome mainly manifested by increased systemic arterial pressure. It is the most common cardiovascular disease. Long-term high blood pressure can affect the functions of the heart, brain, kidneys and other organs, eventually leading to the decline of these organ functions. In view of the dangers of high blood pressure, how to find and discover safe and effective new antihypertensive drugs has become an important task for pharmaceutical workers. At present, there are many kinds of antihypertensive drugs, which are divided into diuretics, adrenoceptor blockers, calcium channel blockers (CCBs), angiotensin converting enzyme inhibitors (ACEIs), angiotensin II receptors according to their mechanism of acti...

Claims

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Application Information

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IPC IPC(8): A61K38/05A61K31/675A61K31/55A61P9/12A61K31/4422A61K31/165
Inventor 邬林祥邬林云
Owner 邬林祥
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