Preparation method of novel alpha-ketovaline calcium
A technology of ketovaline calcium and temperature control, which is applied in the field of drug synthesis, can solve the problems of multiple reaction steps, high toxicity, and high cost, and achieve the effects of mild conditions, low toxicity, and easy operation
Active Publication Date: 2012-09-19
SHAOXING MINSHENG PHARMA
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Route 3 and Route 4 have expensive raw materials, high toxicity, serious pollution, many reaction steps, and high cost, so they are not suitable for industrial production
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Abstract
The invention discloses a preparation method of novel alpha-ketovaline calcium, which comprises the steps of: dropping diethyl oxalate into alcoholic solution of metal alkoxide, then dropping isobutyraldehyde, preserving heat and agitating, adding alkali solution, regulating pH after heat preservation, extracting, adding a certain amount of water into the extract, adding alkali liquor for regulating the pH, dropping calcium chloride water solution for salification to obtain crude alpha-ketovaline calcium and then refining the crude alpha-ketovaline calcium in mixed solvent of purified water and organic solvent to obtain refined alpha-ketovaline calcium. The preparation method has the advantages that the reaction conditions are moderate, the operation is simple to conduct, the steps are fewer, the yield is high, the quality is high, the price of the used raw materials is low, no pollution is caused, waste gas and a great quantity of waste residues are not produced and the method is suitable for industrial mass production.
Description
technical field [0001] The invention relates to the technical field of drug synthesis, in particular to a chemical synthesis preparation method of α-ketovaline calcium. Background technique [0002] α-Ketovaline Calcium, English name: α-Ketovaline Calcium, chemical name: 3-methyl-2-oxo-butyrate calcium, CAS: 51828-94-5. α-Ketovaline Calcium is one of the main components of Compound α-Ketoacid Tablets (Kaitong). α-ketoacids and their derivatives have shown increasingly broad application prospects in food, daily chemicals and medicine. In food applications, it can be used as a component of sports nutrition drinks; in functional skin care cosmetics, it can play a very good role in moisturizing, anti-wrinkle, anti-shrinkage, anti-aging and anti-allergy. In medical applications, compound α-ketoacid tablets can treat damage caused by chronic renal insufficiency, and can be used as a specific drug for treating uremia. For patients with renal failure, taking compound α-ketoacid t...
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IPC IPC(8): C07C59/185C07C51/41
Inventor 邢亚军傅小明黄希
Owner SHAOXING MINSHENG PHARMA
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