Method for extracting arteannuic acid from artemisinin crystallization mother liquor

A technology for crystallizing mother liquor and artemisinic acid, applied in the direction of organic chemistry and the like, can solve the problems of waste of resources, the by-product-artemisinic acid is not well recycled, unfavorable for sustainable development, etc., so as to reduce waste and promote comprehensive development and utilization. Effect

Active Publication Date: 2012-10-03
湖南莱崔尔生物科技有限公司
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Problems solved by technology

[0004] However, many artemisinin manufacturers only use a part of artemisinin resources, and do not recycle the by-product, ar

Method used

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Experimental program
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Embodiment 1

[0023] This embodiment includes the following steps:

[0024] (1) Saponification: Take 50g of artemisinin crystallization mother liquor, add 1000mL petroleum ether (boiling range 60℃~90℃) into it, heat to 50℃, stir for 1 hour; then add dropwise 600mL 1wt% Sodium hydroxide aqueous solution, after insulated and stirred for 2 hours, let it stand for 1 hour, separate the suspended matter in the lower water layer, continue to drop 400mL 1wt% sodium hydroxide aqueous solution in the petroleum ether solution, after insulated and stirred for 2 hours, , stand still for 1 hour, separate the suspended matter in the water layer until the water layer is clean and clear; then wash the petroleum ether layer with water until it is neutral, remove the water, and put the petroleum ether layer at a vacuum degree of -0.06MPa, Concentrate at 60°C until there is no petroleum ether in the extract to obtain 20g of extract;

[0025] (2) Acidification: Add 200mL of 15wt% hydrochloric acid to the extra...

Embodiment 2

[0030] This embodiment includes the following steps:

[0031] (1) Saponification: Take 100g of artemisinin crystallization mother liquor, add 2000mL of petroleum ether (boiling range 60℃~90℃) into it, heat to 50℃, stir for 1 hour; add 1200mL of 1wt% hydrogen into the petroleum ether solution dropwise Potassium oxide aqueous solution, after insulated and stirred for 2 hours, left standstill for 1 hour, the suspended matter in the lower water layer was separated, continued to drop 700mL 1wt% potassium hydroxide aqueous solution in petroleum ether solution, after insulated and stirred for 2 hours, Stand still for 1 hour, separate the suspended matter in the water layer until the water layer is clean and clear; then wash the petroleum ether layer with water until it is neutral, remove the water, and put the petroleum ether layer in a vacuum of -0.06MPa, 55 Concentrate at ℃ until there is no petroleum ether in the extract to obtain 39 g of thick extract;

[0032] (2) Acidification...

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Abstract

A method for extracting arteannuic acid from artemisinin crystallization mother liquor comprises the following steps of (1) saponification; (2) acidification: (3) extraction; (4) dry column chromatography; and (5) purification. By means of the method, high-content arteannuic acid can be effectively separated and purified from the artemisinin crystallization mother liquor, so that the crystallization mother liquor of no use at all at former days is changed to be valuable, waste of resources is reduced, and comprehensive development and utilization of artemisia apiacea resources are promoted.

Description

technical field [0001] The invention relates to a method for extracting artemisinic acid from artemisinin crystallization mother liquor. Background technique [0002] Artemisinin is a sesquiterpene lactone drug with peroxy groups extracted from the traditional Chinese medicine Artemisia annua. It was discovered by Chinese scientists in 1973. It is a high-efficiency, quick-acting, low-toxic antimalarial drug. At present, my country's artemisinin industry has begun to take shape, and has made considerable progress from raw material planting to product production. The by-product of industrial production of artemisinin—artemisinin crystallization mother liquor contains a large amount of artemisinic acid. Due to technical limitations, artemisinin crystallization mother liquor was once regarded as "waste product" and no one cares about it. [0003] Artemisinin is an important precursor of artemisinin. Research data show that artemisinic acid can be converted into artemisinin in ...

Claims

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Application Information

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IPC IPC(8): C07D493/20
Inventor 刘志强
Owner 湖南莱崔尔生物科技有限公司
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