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Application of asiatic acid or salt thereof and injection suspension and preparation method thereof

A technology of asiatic acid and oxalate, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, emulsion delivery, etc. It can solve the problem of no reports on the prevention and treatment of body cavity adhesions, unusable films, and no obvious curative effect, etc. problem, to achieve a good wound healing effect

Inactive Publication Date: 2015-03-11
SHANGHAI INST OF PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, some oral preparations are used to treat body cavity adhesions, but there is no obvious curative effect; at the same time, in view of the special disease of body cavity adhesions, film preparations cannot be used, so it is urgent to develop related drugs that can effectively treat body cavity adhesions
[0003] It is reported in the prior art that asiatic acid and its salts can prevent and treat fibrosis diseases of some internal organs, but there is no report on the prevention and treatment of body cavity adhesions

Method used

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  • Application of asiatic acid or salt thereof and injection suspension and preparation method thereof
  • Application of asiatic acid or salt thereof and injection suspension and preparation method thereof
  • Application of asiatic acid or salt thereof and injection suspension and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030]

[0031] Preparation method: according to the above formula, use a mortar to grind and mix asiatic acid or its salt with a wetting agent, then evenly mix with suspending agent, preservative and water for injection, and then grind. Wherein, the particle size of the grinding is 0.1 μm.

Embodiment 2

[0033]

[0034] Preparation method: according to the above formula, use a mortar to grind and mix asiatic acid or its salt with a wetting agent, then evenly mix with suspending agent, preservative and water for injection, and then grind. Wherein, the particle size of the grinding is 0.3 μm.

Embodiment 3

[0036]

[0037] Preparation method: according to the above formula, use a mortar to grind and mix asiatic acid or its salt with a wetting agent, then evenly mix with suspending agent, preservative and water for injection, and then grind. Wherein, the particle size of the grinding is 0.3 μm.

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PUM

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Abstract

The invention discloses application of asiatic acid or a salt thereof and an injection suspension and a preparation method of the asiatic acid and the salt thereof. The application refers to application of the asiatic acid or the salt thereof to preparation of a medicament for preventing or treating body cavity adhesion. A formula of an injection suspension of the asiatic acid or the salt thereof comprises 0.5-10 percent of asiatic acid or the salt thereof, 0.1-1 percent of a suspending aid, 0.01-0.1 percent of a wetting agent, 0.0-5 percent of a preservative and the balance of water for injection, wherein the percentage refers to the mass percentage of each component in the total amount of the injection suspension. The injection suspension of the asiatic acid or the salt thereof can be used for effectively preventing or treating adhesion of body cavities including chest cavities, abdominal cavities, pleuroperitoneal cavities or joint cavities, and has a good wound healing effect.

Description

technical field [0001] The present invention relates to the application of asiatic acid or its salt, its injection suspension and its preparation method. Background technique [0002] Body cavity adhesion (same as "adhesion") is a complication that is prone to occur after surgery or bacterial inflammation, generally including abdominal cavity, chest cavity, joint cavity and other body cavity adhesions. In the prior art, some oral preparations are used to treat body cavity adhesions, but there is no obvious curative effect; at the same time, in view of the special disease of body cavity adhesions, film preparations cannot be used, so it is urgent to develop related drugs that can effectively treat body cavity adhesions. [0003] It is reported in the prior art that asiatic acid and its salts can prevent and treat some fibrotic diseases of internal organs, but there is no report on the prevention and treatment of body cavity adhesions. Contents of the invention [0004] The...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/56A61K9/10A61P41/00
Inventor 刘英刘全海陆伟根刘珉宇黄晓玲张瑱肖璘蔡立吴学军陈亭亭
Owner SHANGHAI INST OF PHARMA IND CO LTD
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