Combination of multiple genetic single nucleotide polymorphisms related to coronary heart disease and application of combination

A single nucleotide polymorphism, polymorphic site technology, applied in bioreactor/fermenter combination, specific-purpose bioreactor/fermenter, recombinant DNA technology, etc., can solve the exact genetic molecular mechanism knowledge Few, lack of identification methods, etc.

Active Publication Date: 2012-10-31
FUWAI HOSPITAL OF CARDIOVASCULAR DESEASE CHINESE ACAD OF MEDICAL SCI
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Problems solved by technology

From basic to clinical, people have done a lot of research on this, and accumulated a lot of knowledge on the risk factors of coronary heart disease and the pathophysiology of coronary heart disease, but the exact genetic molecular mechanism of coronary heart disease and myocardial infarction is not known Very few, there has been a lack of comprehensive, systematic and effective identification methods for how to identify genetic susceptibility genes and the genetic susceptibility of subjects to coronary heart disease

Method used

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  • Combination of multiple genetic single nucleotide polymorphisms related to coronary heart disease and application of combination
  • Combination of multiple genetic single nucleotide polymorphisms related to coronary heart disease and application of combination
  • Combination of multiple genetic single nucleotide polymorphisms related to coronary heart disease and application of combination

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The selection and detection of a plurality of SNPs of embodiment

[0046] 1. Case-control sample selection criteria

[0047] Cases of coronary heart disease include patients with myocardial infarction and patients with angina pectoris. The diagnostic criteria for the inclusion of myocardial infarction cases are the diagnostic criteria for acute myocardial infarction (according to the diagnostic criteria of WHO in 1979): that is, typical chest pain symptoms lasting for more than 30 minutes; ST-segment elevation in two consecutive leads of electrocardiogram (limb leads 0.1mv, chest lead 0.2mv) with a series of dynamic changes; the concentration of serum markers of myocardial necrosis increased, such as the increase of troponin (TNT / TNI), the increase of myocardial isozyme (CK-MB) was greater than the upper limit of normal value 2 times. The inclusion diagnostic criteria for angina pectoris was that at least one major branch of the coronary artery was found to be narrowe...

Embodiment 2

[0095] Example 2 Example of risk assessment for individuals to be tested for coronary heart disease

[0096] 8579 healthy people and 7012 coronary heart disease patients detected according to the embodiment 1 9 polymorphic sites (rs2123536, rs1842896, rs9349379, rs9268402, rs12524865, rs10757274, rs1333042, rs7136259 and rs11066280) situation, formulate coronary heart disease risk etc. Genetic Contribution Quick Reference Chart ( figure 2 ) and a quick check chart of coronary heart disease risk ( image 3 ). From the lowest group to the highest group of genetic risk factors for coronary heart disease, the risk of coronary heart disease gradually increased, and there was an obvious dose-effect relationship.

[0097] The individual to be tested is Li Si, a Chinese Han nationality, male, 55 years old. Using the detection device for assessing the risk of coronary heart disease of the individual to be tested to evaluate the risk of coronary heart disease of the present inventio...

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Abstract

The invention relates to a combination of multiple genetic single nucleotide polymorphisms related to a coronary heart disease and application of the combination, particularly to the combination of the single nucleotide polymorphisms of rs2123536, rs1842896, rs9349379, rs9268402, rs12524865, rs10757274, rs1333042, rs7136259 and rs11066280, wherein the coronary heart disease risk of an individual of which rs2123536 carries a T allele, rs1842896 carries a T allele, rs9349379 carries a G allele, rs9268402 carries a G allele, rs12524865 carries a C allele, rs10757274 carries a G allele, rs1333042 carries a G allele, rs7136259 carries a T allele and rs11066280 carries an A allele rises to 1.13 to 1.36 times. The invention further relates to a method for detecting the single nucleotide polymorphisms and the combination of the single nucleotide polymorphisms, as well as application to assessing the coronary heart disease risk of people.

Description

technical field [0001] The present invention relates to a combination of multiple gene single nucleotide polymorphism sites related to coronary heart disease and its application, in particular to single nucleotides including rs2123536, rs1842896, rs9349379, rs9268402, rs12524865, rs10757274, rs1333042, rs7136259 and rs11066280 The combination of polymorphic sites, the detection method for the single nucleotide polymorphic sites and the combination thereof, and the application in assessing the risk of coronary heart disease in a population. Background technique [0002] Atherosclerotic cardiovascular and cerebrovascular diseases have become a major health problem worldwide. According to the report of the World Health Organization (WHO) in 2004, the number of deaths caused by cardiovascular diseases, mainly coronary heart disease and stroke, is as high as 17.2 million every year in the world, accounting for one-third of all deaths. It is expected that this number will further...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/11C12Q1/68C12M1/34
Inventor 顾东风鲁向锋黄建凤曹杰王来元李宏帆
Owner FUWAI HOSPITAL OF CARDIOVASCULAR DESEASE CHINESE ACAD OF MEDICAL SCI
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