Preparation method and application for magnetic molecularly imprinted polymers for selectively separating carbamazepine

A magnetic molecular imprinting and polymer technology, applied in the preparation of test samples, alkali metal compounds, chemical instruments and methods, etc., can solve the problems of cumbersome dynamic separation operation, limited application range, and difficult separation, and achieve simplified samples Processing process, expanding the scope of application, good selectivity effect

Active Publication Date: 2013-12-04
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Nano-molecularly imprinted materials have a large specific surface area and have significant advantages in adsorption capacity. However, due to their small size, it is difficult to separate them in actual samples. The dynamic separation process is cumbersome and complicated, which limits their application range. Magnetic molecular imprinting technology provides effective solution

Method used

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  • Preparation method and application for magnetic molecularly imprinted polymers for selectively separating carbamazepine
  • Preparation method and application for magnetic molecularly imprinted polymers for selectively separating carbamazepine
  • Preparation method and application for magnetic molecularly imprinted polymers for selectively separating carbamazepine

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Embodiment 1

[0040] The synthesis method of the magnetic molecularly imprinted polymer selectively adsorbing carbamazepine of the present invention is as follows:

[0041] (1) Synthesis of magnetic chitosan nanoparticles: fully dissolve 0.5 g chitosan in 50 mL 3% (v / v) acetic acid aqueous solution, and add 0.2 g Fe 3 o 4 , Ultrasonic dispersion for 30min. After stirring mechanically for 5 min in a constant temperature water bath at 20-30 °C, add 40 mL of liquid paraffin and 0.5 mL of Span 80 in sequence, and use 25% (v / v) NH 3 ·H 2 O aqueous solution was used to adjust the pH of the solution to 8, and finally 1ml of 25% (v / v) glutaraldehyde solution was added, and the temperature was raised to 50°C for 2 hours. After the reaction, the synthesized magnetic chitosan nanoparticles (chitosan-Fe 3 o 4 ), separated by a permanent magnet, washed repeatedly with absolute ethanol and deionized water for 10 times, and then vacuum-dried at 40°C for later use.

[0042] (2) Pre-assembly solution:...

Embodiment 2

[0056] The synthesis method of the magnetic molecularly imprinted polymer selectively adsorbing carbamazepine of the present invention is as follows:

[0057] (1) Synthesis of magnetic chitosan nanoparticles: fully dissolve 0.5g chitosan in 100mL 3% (v / v) acetic acid solution, and add 0.5g Fe 3 o 4 , Ultrasonic dispersion for 30min. After stirring mechanically for 5 min in a constant temperature water bath at 20-30 °C, add 10 mL of liquid paraffin and 0.5 mL of Span 80 in sequence, and use 25% (v / v) NH 3 ·H 2 O aqueous solution was used to adjust the pH of the solution to 9, and finally 3ml of 25% (v / v) glutaraldehyde solution was added, and the temperature was raised to 60°C for 2 hours. After the reaction, the synthesized magnetic chitosan nanoparticles were separated with a permanent magnet, washed repeatedly with absolute ethanol and deionized water for 15 times, and vacuum-dried at 40°C for future use.

[0058] (2) Pre-assembly solution: Weigh 75.6 (0.32 mmol) carbama...

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Abstract

The invention relates to a preparation method and an application for magnetic molecular imprinting polymers for selectively separating carbamazepine and belongs to the technical fields of environmental material preparation and pollution regulation. Nanometer ferroferric oxide modified on a surface of chitosan serves as a magnetic medium, molecular imprinting material polymerization is carried out on the surface of the nanometer ferroferric oxide by using a sediment polymerization method, and a magnetic molecular imprinting adsorption agent is obtained after template molecular carbamazepine is eluted. Obtained molecular imprinting composite materials are stable in physicochemical property, have high adsorption capacity and specific identification characteristics on the carbamazepine, have superparamagnetism, can be rapidly separated under an outside magnetic field effect, therefore, interference of a complex substrate in an actual sample is avoided, and sample treatment processes are greatly simplified. The preparation method is simple, reliable and low in cost and has a wide application prospect in analysis, detection and pollution treatment of a complex environment sample.

Description

Technical field [0001] The present invention involves a selective separation method and application of magnetic molecular seal polymer for selective separation. Background technique [0002] PHARMACEUTICALS and Personal Care Products (PPCPS) is a new type of pollutant. PPCPS is used in large quantities and special materialization characteristics, which brings certain potential risks to ecological environment and human health.With the development of modern testing technology, people have detected PPCPS in various environmental samples.At present, more than 50 kinds of PPCPS substances have been found in the sewage plant in and out of water, surface water, groundwater and drinking water, with a concentration of up to μg · L. -1 The level, about the behavior, risk research and removal mechanism of PPCPS in environmental media, has become increasingly the focus of environmental researchers and public attention. [0003] Camari Ping (CBZ), the scientific name is 5H-diezen [B, F] nitro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F212/36C08F220/06C08F2/44C08K9/10C08K3/22C08J9/26B01J20/26B01J20/28B01J20/30G01N1/34G01N1/40
Inventor 张亚雷代朝猛张娟高振威周雪飞刘曙光
Owner TONGJI UNIV
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