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Method of assessing risk of multiple births in infertility treatments

A technology for multiple births and infertility, applied in animal births, computer-aided medical procedures, medical sciences, etc., and can solve problems such as ensuring the success rate of eSET

Active Publication Date: 2013-03-20
UNIVFY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The above discussion confirms that multiple births are a significant health and socioeconomic problem for patients undergoing infertility treatment, and that the prior art does not provide an effective way to avoid multiple births and / or ensure the success rate of eSET

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0058] Generation of MBP models and age-controlled models

[0059] Methodology for preparing MBP models and age-controlled models

[0060] Regression tree and boosted tree methods were used to identify severe, nonredundant prognostic factors affecting the risk of multiple births in the ART population. The prognostic factors identified by the regression tree and boosted tree methods were used to generate the MBP model and the age-controlled model described herein.

[0061] The MBP model was established on a cohort of 250 to 500 IVF treatments in which live birth outcomes resulted from the transfer of at least two embryos into female patients.

[0062] For external validation, the MBP model was established on a cohort of 100 to -250 IVF treatments in which live birth outcomes resulted from the transfer of at least two embryos into female patients.

[0063] The MBP model, namely MBP-1 was generated according to the aforementioned steps. Control models used age as the only prog...

example 2

[0066] Statistical comparison between MBP model and age-controlled model

[0067] PLORA test

[0068]The PLORA test is used to calculate the posterior probability of predicting multiple births under the MBP-1 and age-controlled models, as follows:

[0069] MBP-1 has a PLORA of 3.0 (logarithmic scale) and 20 (linear scale).

[0070] Statistical conclusions: MBP-1 provided an improved fit for multiple birth outcomes in a 20:1 ratio compared to the age control model.

[0071] Interpretation: The improved predictive power of MBP-1 in multiple birth outcomes in IVF was 20-fold that of an age-controlled model.

[0072] PLORA for age-controlled models was set to 0 (log scale) and 1 (linear scale).

example 3

[0074] Statistical comparison between MBP model and age-controlled model

[0075] AUC / ROC test

[0076] The AUC / ROC test for predicting the improved ability to discriminate patients with different risks of multiple births in a novel IVF-ET treatment using at least two embryos compared to an age-only model, as follows:

[0077] The AUC for MBP-1 was equal to 0.70; the AUC for the age-controlled model was equal to 0.6.

[0078] MBP-1 improved by 16.7% in its ability to discriminate patients with different risks of multiple births in the novel IVF-ET treatment using at least two embryos compared to the age-only model.

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Abstract

Provided is a multiple birth prognostic tool that is used to analyze data in order to predict a multiple birth event in a female human patient undergoing an infertility treatment. The MBP prognostic tool may also be used to enhance the accuracy of diagnostic or prognostic tests that predict embryo viability. The MBP prognostic tool of the present invention may be clinic specific or it may be modified to be used in a multi-clinic approach.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Patent Application No. 61 / 363,650, filed July 13, 2010, which is incorporated herein by reference in its entirety. technical field [0003] The present invention relates generally to the treatment of infertility. More specifically, the present invention relates to methods for assessing the risk of multiple births in women undergoing infertility treatment. Background technique [0004] Among the treatments for clinical infertility, assisted reproductive technology (ART) has the highest rate of live births per treatment. Voorhis, The New England Journal of Medicine 356, 379-386 (2007). Since its inception, ART has contributed to 1% of live births in the United States each year, resulting in more than one million new babies worldwide. Bonduelle et al, Human Reproduction (Oxford, England) 20 pp. 413-419 (2005); Sunderam et al, MMWRSurveillSumm ) No. 58, pp. 1 to 25...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/00G16Z99/00
CPCG06F19/3431G16H50/30G16H50/50G16Z99/00A61B17/435A61D19/04A61B17/425
Inventor 梅林·姚
Owner UNIVFY
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