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Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device

A technology of therapeutic agents and preparations, applied in drug delivery, pill delivery, drug equipment, etc., which can solve problems such as infection risk

Active Publication Date: 2013-04-03
RANI THERAPEUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Conventional alternative drug delivery methods such as intravenous and intramuscular delivery have many disadvantages including: pain and risk of infection from needles; the need to use sterile technique; and the need to maintain IV lines on the patient for extended periods of time needs and associated risks
While other drug delivery routes such as implantable drug delivery pumps have been employed, these routes require semi-permanent implantation of the device and may still have many of the limitations of intravenous delivery

Method used

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  • Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
  • Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
  • Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device

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Embodiment Construction

[0045] Embodiments of the invention provide devices, systems, and methods for delivering drugs to various locations in the body. The term "drug" as used herein refers to any form of pharmaceutical preparation, which may include a medicament or other therapeutic agent and one or more pharmaceutical excipients. Many embodiments provide swallowable devices for drug delivery within the gastrointestinal tract. Certain embodiments provide a swallowable device such as a capsule for drug delivery to the walls of the small intestine or other gastrointestinal organs.

[0046] Referring now to Figure 1- Figure 11 , an embodiment of the device 10 for delivering a drug 100 to a delivery site DS in the intestinal tract comprises a capsule 20 comprising at least one conduit 30, located within said at least one conduit, or capable of being otherwise positioned within said at least one conduit 30. One or more tissue penetrating members 40, delivery member 50, actuation mechanism 60 and rele...

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Abstract

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to an actuator having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and / or degraded within the GI tract.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of priority to the following U.S. applications: U.S. Application Serial No. 61 / 339,941, filed March 10, 2010 (Attorney Docket No. 028205-000300US), entitled "Swallowable Drug Delivery Device and Methods of Delivery”; 61 / 284,766, filed December 24, 2009 (Attorney Case Docket No. 028205-000200US), titled “Swallowable Drug Delivery Device and Methods of Drug Delivery”; 61 / 340,33 1, Filed March 15, 2010 (Attorney's Case Record No. 028205-000400US), titled "Swallowable Drug Delivery Device and Methods of Delivery"; and 61 / 395,304, filed May 10, 2010 (Attorney's Case Record No. 028205-000500US), entitled "Swallowable Drug Delivery Device and Method of Delivery," all of which are hereby incorporated by reference in their entirety for all purposes. [0003] This application also relates to U.S. Application Serial No.: , filed December 23, 2010 (Attorney Case Docket No. 028205-0005 10US), entit...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K9/22A61K9/20A61K38/28A61P3/10
CPCA61K9/0097A61M31/002A61K9/4816A61K38/28A61K9/0024A61K47/34A61P3/10A61P5/06A61P5/14A61P5/18A61P5/50A61P19/10A61P31/04A61P31/12A61P35/00A61P43/00
Inventor 米尔·A·伊姆兰
Owner RANI THERAPEUTICS
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