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Propylene glycol marinate sulfate-containing sustained-release preparation and preparation method thereof

A technology of sustained-release preparations and glycose esters, which is applied in the field of sustained-release preparations, glycose esters sustained-release preparations and their preparations, and can solve the problems of inability to achieve sustained release, balanced drug administration, and stable release of glycose esters. , to achieve the effects of small fluctuations in blood drug concentration, balanced release, and stable release

Active Publication Date: 2014-06-25
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing glycose ester sustained-release preparations cannot release glycose esters stably within 24 hours, and cannot achieve the effect of sustained release and balanced drug administration, which needs to be improved

Method used

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  • Propylene glycol marinate sulfate-containing sustained-release preparation and preparation method thereof
  • Propylene glycol marinate sulfate-containing sustained-release preparation and preparation method thereof
  • Propylene glycol marinate sulfate-containing sustained-release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of embodiment 1 glycose ester sustained-release preparation

[0021] Take each component by the following parts by weight:

[0022]

[0023] The glycerin ester, the filler and the slow-release matrix matrix are uniformly mixed; the binder is added, the soft material is made, dried and granulated; the lubricant is added, mixed uniformly, and compressed into tablets to obtain the product.

Embodiment 2

[0024] The preparation of embodiment 2 glycose ester sustained-release preparations

[0025] Take each component by the following parts by weight:

[0026]

[0027]

[0028] Mix glycerin ester, filler and slow-release matrix matrix methyl cellulose; add binder, make soft material, dry and granulate; add lubricant, mix evenly, and compress into tablets to obtain.

Embodiment 3

[0029] The preparation of embodiment 3 glycose ester sustained-release preparations

[0030] Take each component by the following parts by weight:

[0031]

[0032] Mix glycerin ester, filler and slow-release matrix matrix hydroxypropyl cellulose uniformly; add binder, make soft material, dry and granulate; add lubricant, mix uniformly, compress into tablets, and obtain the product.

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Abstract

The invention discloses a propylene glycol marinate sulfate sustained-release preparation and a preparation method thereof. The propylene glycol marinate sulfate sustained-release preparation comprises: propylene glycol marinate sulfate, a sustained-release skeleton matrix, a filler, a surfactant, a lubricant and a binder. The propylene glycol marinate sulfate sustained-release preparation disclosed in the invention can achieve long-acting release, and can release drug ingredients stably and evenly within 24h.

Description

technical field [0001] The invention relates to a sustained-release preparation, in particular to a glycose ester sustained-release preparation and a preparation method thereof, and belongs to the field of glycose ester sustained-release preparations. Background technique [0002] Glyceride is the sodium salt of polymannuronic acid propyl ester sulfate obtained by the hydrolysis and esterification of sodium alginate. It is a marine drug for lowering blood fat and antithrombotic, and is used for the treatment of hyperlipidemia. [0003] The sustained-release preparation can stabilize the blood drug concentration after administration, reduce the incidence of adverse reactions, and improve the safety of medication. [0004] The existing glycose ester sustained-release preparations cannot release glycose esters stably within 24 hours, cannot achieve the effect of sustained release and balanced administration, and need to be improved. Contents of the invention [0005] One of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K31/715A61K47/38A61K47/32A61K47/34A61K47/36A61P3/06A61K47/26
Inventor 王明刚任莉陈阳生
Owner CP PHARMA QINGDAO CO LTD
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