54 results about "Long acting release" patented technology

The invention provides a multi-drug controllable-loading and long-acting slow-released biomedical coating material and a preparation method thereof. A preparation process comprises the following steps: polishing, washing and drying a substrate material, soaking in dopamine solution (a negative charge layer), and using a catechol-modified multi-amino biomacromolecule (with a positive charge), electronegative macromolecular solution (with a negative charge), and micelle (with a negative charge) loading multiple drugs as three components of layer-by-layer self-assembly, and preparing a coating modified material on a dopamine-processed substrate by using the above three components through a layer-by-layer self-assembly method. Multiple assembling layers can be repeatedly coated, and multiple drug molecules are largely and orderly fixed on a self-assembling coating, so that controllable long-acting release of a drug is realized.

The invention discloses galanthamine microspheres which contain 5-40wt% of basic group of galanthamine and 60-95wt % of polylactic acid / hydroxyacetic acid copolymer. The invention also provides a galanthamine long-acting release injectable microsphere composite which comprises the following components by weight percent: 60-90% of galanthamine microspheres, 5-25% of frozen dry proppant, 0.5-5% of suspending agent, 0.5-5% of wetting agent and 1-25% of osmotic pressure regulator. The invention combines the vibration nozzle method with the emulsion process (O / W)-solvent evaporation method so thatthe method has the advantage that the droplet-generating speed is fast, the efficiency is high, the containers used in preparation are easy to use in the aseptic operation, the production process canbe carried out continuously, the technology is applicable to scale-up application, etc.

The invention provides a microencapsulated multivesicular liposome drug carrier and a preparation method thereof. The method comprises the following steps: with a sucrose solution as an inner water phase, glucose and an L-lysine solution as outer water phases, and a dichloromethane solution dissolved with lipid as an oil phase, carrying out high-speed homogenate emulsification on the inner water phase and the oil phase to form colostrums; adding the outer water phase, carrying out vortex emulsification to form a compound emulsion, carrying out rotary evaporation to remove dichloromethane, so as to obtain a multivesicular liposome suspension; dispersing the multivesicular liposome into a sodium alginate solution, dispersing uniformly, and then dropping into a calcium chloride solution through a high-pressure microcapsule molding device and an injection pump, so as to prepare calcium alginate gel beads embedded with the multivesicular liposome; and finally forming a film from the gel beads and a cationic polymer solution, so as to form a sample, wherein the drug is carried on at least one part in the multivesicular liposome or out of the multivesicular liposome in the microcapsule. According to the microencapsulated multivesicular liposome drug carrier, space allocation of different drugs is ensured; the long-acting release and absorption of the drug are improved; and toxic and side effects caused by simple use of the drug are reduced.

The invention discloses nonsteroidal anti-inflammatory drug (NSAID) sustained-release nanoparticles and a preparation method thereof, wherein the NSAID sustained-release nanoparticles contain an active component and a carrier, wherein the active component is NSAID, the carrier is polylactic acid polyglycolic acid copolymer (PLGA) nanoparticles, and the active component is loaded in the carrier. According to the present invention, the NSAID sustained-release nanoparticles have good biocompatibility and good slow-release effect, wherein the long-acting release time can reach 15-50 d.

The invention relates to a middle ear anti-adhesion medicine slow-release system and a preparation method and application thereof. The middle ear anti-adhesion medicine slow-release system comprises adiaphragm, a coating covering the diaphragm and medicines, wherein the medicines are loaded onto the diaphragm and the coating. The middle ear anti-adhesion medicine slow-release system has a structure of the internal diaphragm and the external coating, and both the diaphragm and the coating are loaded with the medicines so that the medicines can be released fast, and long-acting release can be achieved; by controlling intrinsic viscosity of diaphragm preparation raw materials and coating preparation raw materials and controlling a mass ratio of the medicines contained in the diaphragm and the coating, a medicine release curve can be made to be more smooth, and a medicine release process can be made to be more stable.

The invention relates to a pest control technology, in particular to an attractant for a stored product pest stegobium paniceum and a preparation method thereof. The attractant is prepared by utilizing a radix notoginseng extract, an orange blossom extract, a lemon peel extract, a mint leaf extract, betaine, sodium alginate, guar gum, modified silicone and water. The attractant disclosed by the invention has the characteristics of small toxic and side effects, small residual quantity, efficient trapping and killing, long-acting release and high broad-spectrum property. The attractant disclosedby the invention is selected from natural components, is small in toxic and side effects and has strong attracting action on stored product pests such as the stegobium paniceum, tribolium castaneum,oryzaephilus surinamensis linne and sitophilus oryzae.

Provided herein are new compositions comprising novel microparticles that are configured to provide a long acting release of one or more treprostinil compounds when administered to mammalian subjects. The microparticles of the invention are biocompatible and typically injectable through a needle or other injection system. The invention also provides methods of using such compositions, such as in the treatment of pulmonary arterial hypertension.

The invention discloses a microcapsule aqueous suspension of the herbicide sethoxydim and a preparation method thereof. It is a sustained-release microcapsule aqueous suspension that adopts the complex coacervation method, uses sethoxydim as the core material, and uses gelatin and gum arabic as the wall materials. The preparation process of the present invention is simpler and more convenient, and the wall material used has the advantages of non-toxicity and biodegradability; the microcapsule water suspension has achieved a high degree of product stability, long-acting slow-release of active ingredients, and has anti-drifting and super high-efficiency , low toxicity, economy and safety features, it is a kind of green and environment-friendly preparation. The microcapsules provided by the invention can be widely used in the control and control of monocotyledonous weeds in dicotyledonous crop fields.

The invention provides a biomedical coating material with multi-drug controllable loading and long-acting sustained release and a preparation method thereof. The preparation process is as follows: the base material is polished, cleaned, dried, and then soaked in a dopamine solution (negatively charged layer), and then use catechol-modified polyamino biomacromolecules (positively charged), negatively charged macromolecular solutions (negatively charged), and micelles loaded with various drugs (negatively charged) as layer-by-layer self-assembly The above three components are used to prepare coating modified materials by layer-by-layer self-assembly method on the dopamine-treated substrate, which can be repeatedly coated with multiple assembly layers to achieve a large number of drug molecules and effective The sequence is immobilized on the self-assembled coating, thereby realizing the controlled long-term release of the drug.

The invention relates to the field of compound fertilizers for crops and in particular relates to a long-acting slow-released compound fertilizer for improving the quality of sesame. The compound fertilizer is prepared from the following raw materials by weight parts: 28-30 parts of urea, 10-12 parts of calcium superphosphate, 25-28 parts of potassium sulfate, 8-10 parts of ground cereals, 30-35 parts of organic compost, 2-3 parts of shrimp shell meal, 10-20 parts of ammonium nitrate, 1-3 parts of copper sulfate, 2-3 parts of zinc sulfate, 1-2 parts of lignosulfonate, 0.1-0.2 part of nanocarbon, 0.01-0.02 part of sodium benzoate, 10-13 parts of an organic silicon emulsion, 5-6 parts of dry jackfruit shells, 0.1-0.2 part of titanyl sulfate, 10-12 parts of plant ash, 5-7 parts of dry thinleaf adina fruit rhizomes, 3-5 parts of bauxite, 0.01-0.02 part of calcium propionate and 3-5 parts of aids. According to the slow-released compound fertilizer, an adsorbent is prepared from the raw materials such as the dry jackfruit shells and the dry thinleaf adina fruit rhizomes, organic matter fermenting liquid with rich active ingredients and the raw materials such as the aids are mixed with the adsorbent, and the effects of controlling the fertility and improving the fertilizer efficiency are achieved by virtue of a slow-released coating agent, so that the utilization rate of nutrients in the sesame is high, the nutrients are quickly accumulated, the product quality is improved, and the planting benefit is high.

The invention discloses a propylene glycol marinate sulfate sustained-release preparation and a preparation method thereof. The propylene glycol marinate sulfate sustained-release preparation comprises: propylene glycol marinate sulfate, a sustained-release skeleton matrix, a filler, a surfactant, a lubricant and a binder. The propylene glycol marinate sulfate sustained-release preparation disclosed in the invention can achieve long-acting release, and can release drug ingredients stably and evenly within 24h.

The invention provides a nifedipine long-acting sustained-release pellet, which comprises the following materials in parts by weight: 8-12 parts of nifedipine, 30-49 parts of welan gum, 5-10 parts of stearic acid, polyethylene glycol Diol 4000 15-20 parts, sorbitol 10-15 parts, lactose 5-10 parts, lubricant 2-5 parts. The preparation method is as follows: firstly, the nifedipine dispersion is prepared with polyethylene glycol and sorbitol as the carrier, then mixed evenly with other raw materials in the sustained-release pellets, added with ethanol aqueous solution to moisten to obtain a soft material, and then the The soft material is respectively prepared into a spherical product through an extrusion machine and a spheronizer, and dried at 45-50° C. for 20-30 hours to obtain sustained-release pellets. The preparation method of the invention is simple, easy to be prepared in large quantities, and the process reproducibility is good. The obtained long-acting sustained-release pills are uniform and stable, can effectively control the release speed of the medicine, and basically have no stimulating effect on the gastrointestinal mucosa.