Middle ear anti-adhesion medicine slow-release system and preparation method and application thereof

An anti-adhesion and drug technology, which is applied in the direction of drug combination, drug delivery, and pharmaceutical formulations, can solve the problems of poor pertinence and uneven sustained release of drugs, and achieve stable release process, increased degradation time, and long-term release. Effect

Active Publication Date: 2019-04-05
PUYI (SHANGHAI) BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The degradable and absorbable drug slow-release magnesium alloy stent involved in this invention not only has excellent mechanical properties, but also has good visibility under X-rays, and can improve and reduce the incidence of restenosis after stent implantation by selecting slow-release drugs , but it has the defects of uneven sustained drug release and poor pertinence at narrow sites

Method used

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  • Middle ear anti-adhesion medicine slow-release system and preparation method and application thereof
  • Middle ear anti-adhesion medicine slow-release system and preparation method and application thereof
  • Middle ear anti-adhesion medicine slow-release system and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] This embodiment provides a middle ear anti-adhesion drug sustained release system, the middle ear anti-adhesion drug sustained release system includes a diaphragm, a coating coated on the surface of the diaphragm and a drug, the drug is loaded on the diaphragm and coated layer. Its preparation method is:

[0064] Dissolve the polyethylene lactide copolymer with an intrinsic viscosity of 0.7dL / g in dichloromethane to make its mass concentration 7.5wt%, stir until the polyethylene lactide copolymer is completely dissolved, then add furoic acid in the solution Mometasone, so that its concentration was 100 μg / mL, stirred until it was completely dissolved to obtain a mixed solution; this mixed solution was added to a flat-bottomed container made of polytetrafluoroethylene, and the container was removed and placed under a fume hood until the dichloromethane was completely volatilized. Obtain the drug-containing diaphragm and place it in a vacuum environment at 37°C for 4 hou...

Embodiment 2

[0067] This embodiment provides a middle ear anti-adhesion drug sustained release system, the middle ear anti-adhesion drug sustained release system includes a diaphragm, a coating coated on the surface of the diaphragm and a drug, the drug is loaded on the diaphragm and coated layer. Its preparation method is:

[0068] Dissolve L-polylactic acid with an intrinsic viscosity of 0.7dL / g in chloroform to make its mass concentration 7.5wt%, stir until the L-polylactic acid is completely dissolved, then add dexamethasone to the solution to make its concentration 100 μg / mL, stirred until completely dissolved to obtain a mixed solution; this mixed solution was added to a flat-bottomed container made of polytetrafluoroethylene, and the container was removed and placed under a fume hood. After the chloroform was completely volatilized, the drug-containing diaphragm was obtained. It is placed in a vacuum environment at 37°C for 4 hours;

[0069] Dissolve L-polylactic acid with an intr...

Embodiment 3

[0071] This embodiment provides a middle ear anti-adhesion drug sustained release system, the middle ear anti-adhesion drug sustained release system includes a diaphragm, a coating coated on the surface of the diaphragm and a drug, the drug is loaded on the diaphragm and coated layer. The difference between its preparation method and Example 1 lies in that the drug content in the prepared middle ear anti-adhesion drug slow-release system coating is 350 μg, the drug content in the diaphragm is 350 μg, and other conditions are the same.

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Abstract

The invention relates to a middle ear anti-adhesion medicine slow-release system and a preparation method and application thereof. The middle ear anti-adhesion medicine slow-release system comprises adiaphragm, a coating covering the diaphragm and medicines, wherein the medicines are loaded onto the diaphragm and the coating. The middle ear anti-adhesion medicine slow-release system has a structure of the internal diaphragm and the external coating, and both the diaphragm and the coating are loaded with the medicines so that the medicines can be released fast, and long-acting release can be achieved; by controlling intrinsic viscosity of diaphragm preparation raw materials and coating preparation raw materials and controlling a mass ratio of the medicines contained in the diaphragm and the coating, a medicine release curve can be made to be more smooth, and a medicine release process can be made to be more stable.

Description

technical field [0001] The invention belongs to the technical field of drug controlled release, and in particular relates to a middle ear anti-adhesion drug sustained release system and its preparation method and application. Background technique [0002] Otitis media is an inflammatory lesion involving all or part of the structure of the middle ear (including the Eustachian tube, tympanic cavity, tympanic antrum, and mastoid air cells), and is more common in children. Among them, the conductive deafness caused by adhesive otitis media is due to certain factors that cause fibrosis and adhesion between the middle ear sound transmission structures and the tympanic wall, which in turn causes movement disorders of the middle ear sound transmission structure system. Middle ear adhesion refers to the fibrous connective tissue adhesion formed by middle ear fibrous tissue and scar hyperplasia, which has a serious negative impact on the movement of the tympanic membrane and ossicular...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/34A61K47/10A61K31/58A61K31/573A61P27/16
CPCA61K47/10A61K47/34A61P27/16A61K9/7007A61K31/573A61K31/58
Inventor 杨瑞晏伟夏佩佩魏征
Owner PUYI (SHANGHAI) BIOTECHNOLOGY CO LTD
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