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Paracetamol and caffeine sustained release preparation and preparation method thereof

A sustained-release preparation and preparation technology, applied in the field of sustained-release preparations, phenolic coffee sustained-release preparations and their preparation, can solve the problems of long-term, sustained-release administration, etc., and achieve small fluctuations in blood drug concentration and balanced release activity The effect of ingredients, good sustained-release effect

Active Publication Date: 2013-05-22
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing phenolic coffee sustained-release preparations do not release the active ingredients acetaminophen and caffeine in a stable and balanced manner within 24 hours, and cannot achieve the effect of long-term, sustained-release administration, and need to be improved

Method used

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  • Paracetamol and caffeine sustained release preparation and preparation method thereof
  • Paracetamol and caffeine sustained release preparation and preparation method thereof
  • Paracetamol and caffeine sustained release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of embodiment 1 phenol coffee sustained-release preparation

[0022] Take each component by the following parts by weight:

[0023]

[0024] Mix the active ingredient (composed of acetaminophen and caffeine in a weight ratio of 1:0.13), filler and slow-release matrix matrix methylcellulose; add binder, make soft material, dry, and granulate; Then add the lubricant, mix evenly, and press into tablets.

Embodiment 2

[0025] The preparation of embodiment 2 phenol coffee sustained-release preparations

[0026] Take each component by the following parts by weight:

[0027]

[0028]

[0029] Mix the active ingredient (composed of acetaminophen and caffeine in a weight ratio of 1:0.13), filler and sustained-release matrix matrix hydroxypropyl cellulose; add binder, make soft material, dry, and granulate ; Then add lubricant, mix evenly, and press into tablets, that is to say.

Embodiment 3

[0030] The preparation of embodiment 3 phenol coffee sustained-release preparations

[0031] Take each component by the following parts by weight:

[0032]

[0033] Mix the active ingredient (composed of acetaminophen and caffeine in a weight ratio of 1:0.13), the filler and the slow-release matrix matrix polyvinylpyrrolidone; add a binder, make a soft material, dry, and granulate; Add lubricant, mix evenly, and press into tablets to get ready.

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PUM

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Abstract

The invention discloses a paracetamol and caffeine sustained release preparation and a preparation method thereof. The paracetamol and caffeine sustained release preparation comprises active ingredients, a slow-release substrate matrix, a filler, a surfactant, a lubricant and an additive, wherein the active ingredients consist of paracetamol and caffeine in ratio by weight of 1:0.13. The paracetamol and caffeine sustained release preparation disclosed by the invention is capable of realizing the long-acting release and stably and regularly releasing the active ingredients within 24 hours.

Description

technical field [0001] The invention relates to a slow-release preparation, in particular to a phenol coffee slow-release preparation and a preparation method thereof, and belongs to the field of phenol coffee slow-release preparations. Background technique [0002] The active ingredients of the phenol coffee pharmaceutical preparation are acetaminophen and caffeine, and are used for fever caused by common cold or influenza. It is also used to relieve mild to moderate pain, such as headache, migraine, toothache, neuralgia, muscle pain, dysmenorrhea and joint pain. [0003] The sustained-release preparation can stabilize the blood drug concentration after administration, reduce the incidence of adverse reactions, and improve the safety of medication. [0004] The existing sustained-release preparations of phenol coffee do not release the active ingredients acetaminophen and caffeine in a stable and balanced manner within 24 hours, and cannot achieve the effect of long-term, ...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61K31/167A61K9/22A61K47/38A61K47/34A61K47/32A61P29/00
Inventor 王明刚陈阳生任莉
Owner CP PHARMA QINGDAO CO LTD
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