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A biomedical coating material with multi-drug controllable loading and long-acting sustained release and preparation method thereof

A biomedical and coating material technology, applied in coating, application, medical science and other directions, can solve the problems of easy to produce sudden release, inability to load a large amount of hydrophobic drugs, and low drug loading in drug-loaded coatings, and achieve high performance. Effects of research and applied value

Active Publication Date: 2019-06-04
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the above-mentioned problems existing in the prior art, the present invention provides a multi-drug controllable loading and long-acting slow-release biomedical coating material and its preparation method, which can effectively solve the problem of low drug loading in existing drug-loaded coatings. , it is impossible to load a large amount of hydrophobic drugs, resulting in a single type of drug loading, and the problem of burst release is prone to occur

Method used

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  • A biomedical coating material with multi-drug controllable loading and long-acting sustained release and preparation method thereof
  • A biomedical coating material with multi-drug controllable loading and long-acting sustained release and preparation method thereof

Examples

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Embodiment 1

[0035] A biomedical coating material with multi-drug controllable loading and long-acting sustained release, the preparation method of which comprises the following steps:

[0036] (1) the chitosan of MW=100,000 is formulated into the chitosan solution that concentration is 2mg / ml, and pH value is 2.0, then regulates chitosan solution pH with the hydrochloric acid of 1mol / L and the sodium hydroxide of 1mol / L value to 5.0;

[0037] Dissolve 1g of 3,4-dihydroxybenzaldehyde in 50ml of methanol solution, and then slowly add it dropwise to the chitosan solution with a pH value of 5.0 under the protection of nitrogen, react for 2 hours after the drop is complete, and then slowly add enough Sodium borohydride until no bubbles are produced, and then use a 10,000 molecular weight dialysis bag to dialyze in deionized water with a pH value of 5.0 for 3 days, take it out and freeze-dry, and prepare the obtained sample to a concentration of 2 mg / ml and a pH value of 6.5 The solution; Wher...

Embodiment 2

[0044] A biomedical coating material with multi-drug controllable loading and long-acting sustained release, the preparation method of which comprises the following steps:

[0045] (1) the chitosan of MW=100,000 is formulated into the chitosan solution that concentration is 2mg / ml, and pH value is 2.0, then regulates chitosan solution pH with the hydrochloric acid of 1mol / L and the sodium hydroxide of 1mol / L value to 5.0;

[0046] Dissolve 1g of 3,4-dihydroxybenzaldehyde in 50ml of methanol solution, and then slowly add it dropwise to the chitosan solution with a pH value of 5.0 under the protection of nitrogen, react for 2 hours after the drop is complete, and then slowly add enough Sodium borohydride until no bubbles are produced, and then use a 10,000 molecular weight dialysis bag to dialyze in deionized water with a pH value of 5.0 for 3 days, take it out and freeze-dry, and prepare the obtained sample to a concentration of 2 mg / ml and a pH value of 6.5 The solution; Wher...

Embodiment 3

[0055] A biomedical coating material with multi-drug controllable loading and long-acting sustained release, the preparation method of which comprises the following steps:

[0056] (1) the chitosan of MW=100,000 is formulated into the chitosan solution that concentration is 2mg / ml, and pH value is 2.0, then regulates chitosan solution pH with the hydrochloric acid of 1mol / L and the sodium hydroxide of 1mol / L value to 5.0;

[0057] Dissolve 1g of 3,4-dihydroxybenzaldehyde in 50ml of methanol solution, and then slowly add it dropwise to the chitosan solution with a pH value of 5.0 under the protection of nitrogen, react for 2 hours after the drop is complete, and then slowly add enough Sodium borohydride until no bubbles are produced, and then use a 10,000 molecular weight dialysis bag to dialyze in deionized water with a pH value of 5.0 for 3 days, take it out and freeze-dry, and prepare the obtained sample to a concentration of 2 mg / ml and a pH value of 6.5 The solution; Wher...

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Abstract

The invention provides a biomedical coating material with multi-drug controllable loading and long-acting sustained release and a preparation method thereof. The preparation process is as follows: the base material is polished, cleaned, dried, and then soaked in a dopamine solution (negatively charged layer), and then use catechol-modified polyamino biomacromolecules (positively charged), negatively charged macromolecular solutions (negatively charged), and micelles loaded with various drugs (negatively charged) as layer-by-layer self-assembly The above three components are used to prepare coating modified materials by layer-by-layer self-assembly method on the dopamine-treated substrate, which can be repeatedly coated with multiple assembly layers to achieve a large number of drug molecules and effective The sequence is immobilized on the self-assembled coating, thereby realizing the controlled long-term release of the drug.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a biomedical coating material with multi-drug controllable loading and long-acting sustained release and a preparation method thereof, which can be used as a long-acting antibacterial, anti-inflammatory, and repair-promoting dressing for wounds. Anti-inflammatory, bone growth-promoting, anti-osteoporosis, anti-tumor, bone-inducing and cartilage-inducing surface-modified coatings for artificial bone materials, and surface-modified coatings for blood-contact materials. Background technique [0002] Some unfavorable interactions between tissues and materials will occur after medical materials are in contact with body tissues. For example, with the application of cardiovascular stent materials in vascular stenosis, early and late thrombosis problems caused by coagulation factors, in damaged blood vessels Due to the failure of rapid endothelialization, excessive ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/10A61L15/24A61L15/26A61L15/28A61L15/44A61L24/00A61L24/04A61L24/06A61L24/08A61L27/34A61L27/54
CPCA61L15/10A61L15/24A61L15/26A61L15/28A61L15/44A61L24/0015A61L24/046A61L24/06A61L24/08A61L27/34A61L27/54A61L2300/602A61L2300/606A61L2300/608
Inventor 罗日方王云兵陆奖庄伟华杨立李高参
Owner SICHUAN UNIV
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