Multi-drug controllable-loading and long-acting slow-released biomedical coating material and preparation method thereof

A biomedical and coating material technology, applied in coating, application, medical science and other directions, can solve the problems of easy to produce sudden release, unable to load a large amount of hydrophobic drugs, single type of drug loading, etc., and achieve high research and application value Effect

Active Publication Date: 2018-11-16
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the above-mentioned problems existing in the prior art, the present invention provides a multi-drug controllable loading and long-acting slow-release biomedical coating material and its preparation method, which can effectively solve the problem of low drug loading in existing drug-loaded coatings. , it is impossible to load a large amount of hydrophobic drugs, resulting in a single type of drug loading, and the problem of burst release is prone to occur

Method used

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  • Multi-drug controllable-loading and long-acting slow-released biomedical coating material and preparation method thereof
  • Multi-drug controllable-loading and long-acting slow-released biomedical coating material and preparation method thereof

Examples

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Embodiment 1

[0035] A biomedical coating material with multi-drug controllable loading and long-acting sustained release, the preparation method of which comprises the following steps:

[0036] (1) the chitosan of MW=100,000 is formulated into the chitosan solution that concentration is 2mg / ml, and pH value is 2.0, then regulates chitosan solution pH with the hydrochloric acid of 1mol / L and the sodium hydroxide of 1mol / L value to 5.0;

[0037] Dissolve 1g of 3,4-dihydroxybenzaldehyde in 50ml of methanol solution, and then slowly add it dropwise to the chitosan solution with a pH value of 5.0 under the protection of nitrogen, react for 2 hours after the drop is complete, and then slowly add enough Sodium borohydride until no bubbles are produced, and then use a 10,000 molecular weight dialysis bag to dialyze in deionized water with a pH value of 5.0 for 3 days, take it out and freeze-dry, and prepare the obtained sample to a concentration of 2 mg / ml and a pH value of 6.5 The solution; Wher...

Embodiment 2

[0044] A biomedical coating material with multi-drug controllable loading and long-acting sustained release, the preparation method of which comprises the following steps:

[0045] (1) the chitosan of MW=100,000 is formulated into the chitosan solution that concentration is 2mg / ml, and pH value is 2.0, then regulates chitosan solution pH with the hydrochloric acid of 1mol / L and the sodium hydroxide of 1mol / L value to 5.0;

[0046] Dissolve 1g of 3,4-dihydroxybenzaldehyde in 50ml of methanol solution, and then slowly add it dropwise to the chitosan solution with a pH value of 5.0 under the protection of nitrogen, react for 2 hours after the drop is complete, and then slowly add enough Sodium borohydride until no bubbles are produced, and then use a 10,000 molecular weight dialysis bag to dialyze in deionized water with a pH value of 5.0 for 3 days, take it out and freeze-dry, and prepare the obtained sample to a concentration of 2 mg / ml and a pH value of 6.5 The solution; Wher...

Embodiment 3

[0055] A biomedical coating material with multi-drug controllable loading and long-acting sustained release, the preparation method of which comprises the following steps:

[0056] (1) the chitosan of MW=100,000 is formulated into the chitosan solution that concentration is 2mg / ml, and pH value is 2.0, then regulates chitosan solution pH with the hydrochloric acid of 1mol / L and the sodium hydroxide of 1mol / L value to 5.0;

[0057] Dissolve 1g of 3,4-dihydroxybenzaldehyde in 50ml of methanol solution, and then slowly add it dropwise to the chitosan solution with a pH value of 5.0 under the protection of nitrogen, react for 2 hours after the drop is complete, and then slowly add enough Sodium borohydride until no bubbles are produced, and then use a 10,000 molecular weight dialysis bag to dialyze in deionized water with a pH value of 5.0 for 3 days, take it out and freeze-dry, and prepare the obtained sample to a concentration of 2 mg / ml and a pH value of 6.5 The solution; Wher...

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Abstract

The invention provides a multi-drug controllable-loading and long-acting slow-released biomedical coating material and a preparation method thereof. A preparation process comprises the following steps: polishing, washing and drying a substrate material, soaking in dopamine solution (a negative charge layer), and using a catechol-modified multi-amino biomacromolecule (with a positive charge), electronegative macromolecular solution (with a negative charge), and micelle (with a negative charge) loading multiple drugs as three components of layer-by-layer self-assembly, and preparing a coating modified material on a dopamine-processed substrate by using the above three components through a layer-by-layer self-assembly method. Multiple assembling layers can be repeatedly coated, and multiple drug molecules are largely and orderly fixed on a self-assembling coating, so that controllable long-acting release of a drug is realized.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a biomedical coating material with multi-drug controllable loading and long-acting sustained release and a preparation method thereof, which can be used as a long-acting antibacterial, anti-inflammatory, and repair-promoting dressing for wounds. Anti-inflammatory, bone growth-promoting, anti-osteoporosis, anti-tumor, bone-inducing and cartilage-inducing surface-modified coatings for artificial bone materials, and surface-modified coatings for blood-contact materials. Background technique [0002] Some unfavorable interactions between tissues and materials will occur after medical materials are in contact with body tissues. For example, with the application of cardiovascular stent materials in vascular stenosis, early and late thrombosis problems caused by coagulation factors, in damaged blood vessels Due to the failure of rapid endothelialization, excessive ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/10A61L15/24A61L15/26A61L15/28A61L15/44A61L24/00A61L24/04A61L24/06A61L24/08A61L27/34A61L27/54
CPCA61L15/10A61L15/24A61L15/26A61L15/28A61L15/44A61L24/0015A61L24/046A61L24/06A61L24/08A61L27/34A61L27/54A61L2300/602A61L2300/606A61L2300/608
Inventor 罗日方王云兵陆奖庄伟华杨立李高参
Owner SICHUAN UNIV
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