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Preparation method of targeted controlled release arsenical medicine

A drug and targeting technology, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations of non-active ingredients, etc., can solve the problems of difficult and stable control of the release rate, and achieve the effects of reducing drug side effects, improving treatment efficiency, and facilitating drug use

Inactive Publication Date: 2014-12-03
TIANJIN VOCATIONAL INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention aims at the problem that the release rate of the existing magnetic nano-silica is not easy to be stably controlled when the arsenic drug carrier is used, and adopts the arsenic drug and the porous magnetic Fe 3 o 4 Co-precipitation, the adsorption of arsenic drugs on magnetic Fe 3 o 4 Surface and interior, delay its release rate; then use porous nano-silica to coat the arsenic drug, so as to realize the long-term sustained release and controllable release of the arsenic drug, and polyvinylpyrrolidone polymer sol can also be used Surface treatment improves its biocompatibility

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0017] Weigh 0.54 gram of ferric chloride [FeCl 3 6H 2 O], 0.78 grams of ammonium ferrous sulfate [(NH 4 ) 2 Fe(SO 4 ) 2 .6H 2 O] and 0.13 g of sodium arsenite [NaAsO 2 ], dissolved in 50 ml of deionized water, added 5 ml of ammonia water with a concentration of 25% under strong stirring, reacted in a water bath at 50°C for 15 minutes, and separated the black magnetic Fe by magnetic attraction 3 o 4 Solid, wash 3-5 times with deionized water, dry the precipitate at 105°C to obtain nano-magnetic Fe loaded with arsenic drug with a particle size of 50nm 3 o 4 nuclear.

[0018] Measure 120mL of deionized water and heat it to 80°C, under vigorous stirring, add the above-mentioned nano-magnetic Fe loaded with arsenic drug 3 o 4 Core and 0.6g of quaternary ammonium salt surfactant, ultrasonic 10 minutes to obtain Fe 3 o 4 For nano-sol, add 3ml of concentrated ammonia water to adjust the pH of the solution to be greater than 11, add 10mL of ethyl silicate, and react at a ...

Embodiment 2

[0021] Weigh 0.54 gram of ferric chloride [FeCl 3 6H 2 O], 0.78 grams of ammonium ferrous sulfate [(NH4 ) 2 Fe(SO 4 ) 2 .6H 2 O] and 0.03 g of sodium arsenite [NaAsO 2 ], dissolved in 50 ml of deionized water, added 5 ml of ammonia water with a concentration of 25% under strong stirring, reacted in a water bath at 50°C for 15 minutes, and separated black Fe by magnet attraction. 3 o 4 Solid, wash 3-5 times with deionized water, dry the precipitate at 105°C to obtain nano-magnetic Fe loaded with arsenic drug with a particle size of 50nm 3 o 4 nuclear.

[0022] Measure 120mL of deionized water and heat it to 60°C, under vigorous stirring, add the nano-magnetic Fe loaded with arsenic drug prepared above 3 o 4 Core and 0.6g of quaternary ammonium salt surfactant, ultrasonic 10 minutes to obtain Fe 3 o 4 For nano sol, add 3ml of concentrated ammonia water to adjust the pH of the solution to be greater than 11, add 10mL of ethyl silicate, and react at a constant temperat...

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Abstract

The invention discloses a preparation method of a targeted controlled release arsenical medicine. The preparation process comprises three steps: preparation of an arsenical medicine-loaded magnetic Fe3O4 core, coating of the magnetic arsenical medicine by nanosilicon dioxide and biocompatibility of the arsenical medicine. According to the preparation method disclosed by the invention, the arsenical medicine and porous magnetic Fe3O4 are coprecipitated and the arsenical medicine is adsorbed on the surface of the magnetic Fe3O4, so that the release speed is delayed. The arsenical medicine is coated by using porous nanosilicon dioxide so as to realize targeted long-acting release and controlled release of the arsenical medicine. Surface treatment is carried out on the arsenical medicine by using a polyvinylpyrrolidone macromolecular sol, so that the biocompatibility is improved. The preparation method disclosed by the invention can be used for solving the problem that an existing controlled release arsenical medicine preparation process is complex and unstable in release speed, and can be used for realizing targeted delivery, reducing the side effects of the medicine and improving the curative effect.

Description

technical field [0001] The present invention relates to a preparation method of targeting and controllable releasing arsenic drug, in particular to a magnetic triiron tetroxide core coated with arsenic by using porous nano silicon dioxide as the shell, which can realize the targeting of arsenic The invention relates to a preparation method of long-acting slow-release medicine, which belongs to the fields of fine chemical industry and nanometer technology. Background technique [0002] Arsenic trioxide is the main component of traditional Chinese medicine arsenic. It has been used in traditional Chinese medicine for a long time. It has the characteristics of safety and relatively low toxicity. It is expected to become a new anticancer drug with high efficiency and low toxicity. Cancer, and has the effect of reversing the resistance of tumor cells to chemotherapeutic drugs. The effect of arsenic on cancer has two sides, that is, arsenic has an inhibitory effect on cancer unde...

Claims

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Application Information

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IPC IPC(8): A61K33/36A61K47/04A61K9/51A61P35/00
Inventor 李霞李建生于韶梅王韬李无为王丽华
Owner TIANJIN VOCATIONAL INST
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