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Resveratrol composite membrane agent and preparation method thereof

A technology of resveratrol and composite film, which is applied in the field of preparation of resveratrol composite film and the above-mentioned resveratrol composite film, which can solve the problems of poor mechanics, anti-ultraviolet, limited application, and high price of polylactic acid and other issues to achieve the effect of improving compatibility

Active Publication Date: 2018-11-06
TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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AI Technical Summary

Problems solved by technology

[0005] However, polylactic acid is expensive and has poor mechanical and anti-ultraviolet properties, which greatly limit its application in the field of biomedicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0017] Example: Preparation of L-polylactic acid / alkali lignin grafted D-polylactic acid / resveratrol film agent

[0018] Dissolve 0.1g of alkali lignin in 10mL of N,N-dimethylformamide (DMF), stir for 20min to dissolve it completely, and obtain an alkali lignin / DMF solution with a concentration of 10% (w / w); add 2.9 g of D-lactide (D-LA) and 0.077g of 4-dimethylaminopyridine (DMAP), then heated to 80°C and reacted for 24h. After the reaction is finished, cool to room temperature, add deionized water to wash, and dry to obtain alkali lignin grafted D-polylactic acid copolymer.

[0019] Take 5 mg of the alkali lignin grafted D-polylactic acid copolymer and 0.5 g of L-polylactic acid in Example 1 and dissolve them in 2 mL of chloroform respectively, add 10 mg of resveratrol after mixing, and ultrasonically treat for 5 minutes to mix evenly, then place it in a Stir on a magnetic stirrer for 1h, 600r / min; finally cast the resulting solution on a polytetrafluoroethylene plate, and ...

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Abstract

The invention relates to a resveratrol composite film agent. The film agent takes L-polylactic acid and lignin-grafted D-polylactic acid copolymer as a main film forming material; by utilizing a solution blending method and simultaneously introducing resveratrol, the composite film agent with good mechanical property, thermal stability, UV resistance, biocompatibility and drug slow release is prepared in a compounding manner. On one hand, a stereocomplex formed by L-polylactic acid and D-polylactic acid molecular chains can significantly improve the compatibility of the polylactic acid with the lignin and improve the mechanical properties of the lactic acids; on the other hand, the lignin and resveratrol have a similar polyphenol structure and a certain ultraviolet resistance, so that thestability of the resveratrol can be improved, and the long-acting release is realized.

Description

technical field [0001] The invention belongs to the field of functional polymer materials and biomedicine. Specifically relates to a resveratrol composite membrane agent. [0002] The invention also relates to a preparation method of the above-mentioned resveratrol composite film agent. Background technique [0003] Resveratrol is a plant complement mainly found in seed plants and belongs to the non-flavonoid polyphenolic compounds. Studies have found that in addition to improving plant disease resistance, resveratrol has a variety of biological effects, such as cardiovascular protection, anti-inflammation, blood lipid regulation, and inhibition of platelet aggregation. [0004] Implantable drug delivery system (IDDS) is a kind of drug release preparation that is surgically implanted or punctured into the body or subcutaneously, and is a long-term drug delivery system. IDDS can increase the drug concentration in specific parts, make the drug closer to the target tissue, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08L87/00C08K5/13C08G83/00C08J5/18
CPCC08G83/00C08J5/18C08J2367/04C08J2487/00C08K5/13
Inventor 戴林邹竹帆周文琴
Owner TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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