Galanthamine long-acting release injectable microsphere composite and preparation method thereof

Abstract

The invention discloses galanthamine microspheres which contain 5-40wt% of basic group of galanthamine and 60-95wt % of polylactic acid / hydroxyacetic acid copolymer. The invention also provides a galanthamine long-acting release injectable microsphere composite which comprises the following components by weight percent: 60-90% of galanthamine microspheres, 5-25% of frozen dry proppant, 0.5-5% of suspending agent, 0.5-5% of wetting agent and 1-25% of osmotic pressure regulator. The invention combines the vibration nozzle method with the emulsion process (O / W)-solvent evaporation method so thatthe method has the advantage that the droplet-generating speed is fast, the efficiency is high, the containers used in preparation are easy to use in the aseptic operation, the production process canbe carried out continuously, the technology is applicable to scale-up application, etc.

Description

technical field

[0001] The invention relates to an injection microsphere composition and a preparation method, more specifically, to a biodegradable galantamine long-acting injection sustained-release microsphere composition and a preparation method. Background technique

[0002] Galantamine is a second-generation competitive cholinesterase inhibitor, which can pass through the blood-brain barrier, restore hindered neuromuscular conduction, and improve the paralysis of various peripheral neuromuscular disorders. In the early days, it was used to treat myasthenia gravis. In recent years, it has been found that galantamine can significantly improve the memory of elderly patients. It is mainly used for the treatment of mild, moderate and severe Alzheimer's disease (AD), and the curative effect is remarkable after 6 to 8 weeks of medication. , This product is suitable for benign memory disorders, improving the ability of patients to point to memory, associative learning, image r...

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