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Traditional Chinese medicine composition for preventing and treating cardiac muscle fibers or myocardial hypertrophy

A technology of myocardial fibrosis and composition, which is applied in the field of traditional Chinese medicine composition for the prevention and treatment of myocardial fibrosis or myocardial hypertrophy, can solve the problems of inability to obtain myocardial hypertrophy, limited effect, lack of pertinence, etc., and achieve the goal of reducing whole heart weight/body weight Effect

Active Publication Date: 2015-07-15
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, among these drugs, only angiotensin-converting enzyme inhibitors have achieved a certain clinical therapeutic effect, but the effect is limited, and they cannot achieve very obvious anti-myocardial fibrosis or myocardial hypertrophy effects. There is no obvious evidence for other drugs so far. It can improve myocardial fibrosis or myocardial hypertrophy, so there is currently a lack of targeted and effective therapeutic drugs

Method used

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  • Traditional Chinese medicine composition for preventing and treating cardiac muscle fibers or myocardial hypertrophy
  • Traditional Chinese medicine composition for preventing and treating cardiac muscle fibers or myocardial hypertrophy
  • Traditional Chinese medicine composition for preventing and treating cardiac muscle fibers or myocardial hypertrophy

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Experimental program
Comparison scheme
Effect test

Embodiment

[0027] Experimental data are used to demonstrate the in vivo anti-myocardial fibrosis or myocardial hypertrophy effect of the traditional Chinese medicine composition of the present invention.

[0028] 1. Test drug

[0029] Weigh the 7-day amount of the crude drug in proportion, add 18 times the amount of 50% ethanol to reflux and extract for 3 times, each time for 1.5 hours. Filter, combine the extracts, concentrate under reduced pressure to the equivalent of 1g of crude drug per milliliter.

[0030] 2. Experimental animals

[0031] Wiatar rats, male, weighing 250-300 g, were provided by Shanghai Xipuer-Bikay Experimental Animal Co., Ltd. [SCXK (Shanghai) 2008-0016].

[0032] 3. Experimental method

[0033] 3.1 Establishment of myocardial fibrosis or myocardial hypertrophy model

[0034] Rats were anesthetized by intraperitoneal injection of 10% chloral hydrate (0.3mL·100g-1) and fixed on the operating table. Turn on the ventilator (respiratory frequency 72 times min-1, ...

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Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating cardiac muscle fibers or myocardial hypertrophy. The traditional Chinese medicine composition is prepared from the following bulk pharmaceutical chemicals in parts by weights based on the traditional Chinese medicines: 50 to 30 parts of panax japonicus, 8 to 36 parts of fructus trichosanthis, 10 to 30 parts of kudzuvine root, 8 to 24 parts of ligusticum wallichii, and 6 to 28 parts of allium macrostemon. As the animal experiment and statistical analysis shown, after a rate subjected to cardiac muscle fibers or myocardial hypertrophy is given the traditional Chinese medicine composition, the full heart weight / body weight, cardiac ventricle weight / body weight, heart tissue inflammatory cells and cardiac muscle cell interstitial collagen are obviously reduced, the CVF (Collagen Volume Fraction) is obviously reduced, and therefore, that the composition has the effect of preventing and treating the cardiac muscle fibers or the myocardial hypertrophy is determined. The traditional Chinese medicine composition can be prepared into tablets, capsules, granules, oral liquid or injection together with pharmaceutically acceptable auxiliary materials.

Description

technical field [0001] The invention belongs to the field of clinical application of traditional Chinese medicine, and mainly relates to the application of a Chinese medicine composition in preventing and treating myocardial fibrosis or myocardial hypertrophy, and meanwhile, the invention also relates to a preparation method of the Chinese medicine composition. Background technique [0002] Myocardial fibrosis or myocardial hypertrophy is a kind of ventricular remodeling that occurs when the heart is overloaded for a long time. In addition to the deposition of connective tissue between myocardial cells, it is also accompanied by increased protein synthesis and cell volume in myocardial cells, which seriously affects the normal contraction and function of the heart. Diastolic function. Myocardial fibrosis or myocardial hypertrophy is a common complication and pathological basis of various cardiovascular diseases, such as hypertension, coronary heart disease, valvular heart di...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8962A61P9/04
Inventor 丁永芳彭蕴茹沈红沈明勤
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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