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Anti-wrinkle polypeptide compound, cosmetic containing same and preparation method of anti-wrinkle polypeptide compound

A technology for cosmetics and skin wrinkles, which is applied in the field of anti-wrinkle polypeptide compounds and external anti-wrinkle cosmetics to achieve good wrinkles, delay the reduction of collagen, and improve the effect

Pending Publication Date: 2022-07-29
湖州闪思新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0023] However, there are no documents and patents reporting any activity of the above-mentioned silver sapleuridine

Method used

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  • Anti-wrinkle polypeptide compound, cosmetic containing same and preparation method of anti-wrinkle polypeptide compound
  • Anti-wrinkle polypeptide compound, cosmetic containing same and preparation method of anti-wrinkle polypeptide compound
  • Anti-wrinkle polypeptide compound, cosmetic containing same and preparation method of anti-wrinkle polypeptide compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Embodiment 1 The multiple skin irritation test of silver saihu cyclic peptide aqueous solution (refer to Chinese patent CN 102429846 B test method implementation)

[0070] 1. Materials and methods

[0071] 1. The test substance is 10% Yin saiko cyclopeptide aqueous solution

[0072] 2. Test animals: 4 white New Zealand domestic rabbits

[0073] 3. Test method: 24 hours before the test, the hair on both sides of the animal's back spine was shaved, and the shaving area was about 3cm × 3cm on the left and right sides. During the test, 0.5mL of the test substance was evenly applied to the left skin of about 2.5cm × 2.5cm. On the right, distilled water was used as a control. Apply once a day for 7 days. From the second day, the hair was removed before application and washed with warm water. After 1 hour, the skin reaction was observed and the skin irritation reaction was scored. After the test, the 14-day total score and the 14-day average score of each animal were calcul...

Embodiment 2

[0078] Example 2 Skin allergy test of silver saiko cyclopeptide aqueous solution (refer to Chinese patent CN 102429846 B test method and 2015 edition of cosmetic safety technical specifications)

[0079] 1. Materials and methods

[0080] 1. Preparation method of test substance: 10% Yin saiko cyclopeptide aqueous solution

[0081] 2. Test animals: Common-grade British albino guinea pigs, divided into three groups, the test substance experimental group and the positive substance experimental group, with 20 animals in each group and 20 test substance control groups.

[0082] 3. Test method:

[0083] Induced contact: apply 0.2 ml of the test substance for induction on the skin of the shaved 2cm×2cm area on the left side of the animals in the experimental group of the test substance, covered with two layers of gauze and one layer of cellophane, fixed with non-irritating tape, and sealed for 6 hours . 7d and 14d are repeated in the same way. The positive substance experimental g...

Embodiment 3

[0089] Example 3 Yin Chaihu cyclic peptide MMP-1 inhibitory activity (implemented with reference to Chinese patent CN 111182887 A test method)

[0090] The inhibitory effect of matrix metalloproteinase-1 (MMP-1) was investigated in skin fibroblasts with different concentrations (0.01%-10%) of Yingaihu cyclic peptide solution.

[0091] Human skin fibroblasts were plated at 3 × 10 4 The density of CFU / well was put into 96-well plates and incubated with FGM-2 medium at 37°C for 24 hours. The medium was removed, then 180 microliters of fresh medium was dispensed into each well, and 20 microliters including various concentrations of Yin saiko cyclopeptide or distilled water (control) were added thereto, followed by incubation at 37°C for 24 hours . After 24 hours of incubation, the supernatant was collected and the amount of matrix metalloproteinase-1 (MMP-1) in the culture medium was measured using the Human Review MMP-1 kit.

[0092] The following is a schematic diagram of the...

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Abstract

The invention relates to an anti-wrinkle polypeptide compound, a cosmetic containing the compound and a preparation method of the cosmetic. The invention discloses application of radices stellariae dichotomae cyclopeptide in preparation of cosmetics for relieving facial wrinkles for the first time. In-vitro experiments prove that the radices stellariae dichotomae cyclopeptide has a remarkable MMP-1 inhibiting effect. And the radices stellariae dichotomae cyclopeptide is used as an anti-wrinkle component to prepare an anti-wrinkle cosmetic. Animal experiments prove that the obtained cosmetic has a good anti-wrinkle effect, wrinkles of experimental animals can be effectively relieved, and finally a certain anti-aging effect is achieved.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to an anti-wrinkle polypeptide compound and an external anti-wrinkle cosmetic containing the compound, as well as a preparation process and application thereof. Background technique [0002] Aging, also known as aging, usually refers to the gradual process of functional and organic decline that occurs with age after an organism matures under normal conditions [Fu Yicai, Jin Xipeng, Skin Aging and Cell Aging[J]·· J Clin Dermatology, 2000;29(4):245-7]. [0003] One of the main causes of skin aging is a change in the structure of the dermis layer. There are many causes of changes in the structure of the dermis of the skin. Among them, the activation of matrix metalloproteinases (MMPs) in the body due to the action of some external factors can lead to excessive degradation of collagen and elastin in the skin dermis that support the skin structure, resulting in skin shrin...

Claims

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Application Information

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IPC IPC(8): A61K8/64A61Q19/08
CPCA61K8/645A61Q19/08A61K2800/782
Inventor 不公告发明人
Owner 湖州闪思新材料科技有限公司
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