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Dissolving method of L-tetrahydropalmatine, L-tetrahydropalmatine solution and application of L-tetrahydropalmatine solution

A technology of L-tetrahydropalmatine and solution, which is applied in the field of food and medicine, can solve problems such as safety hazards, unsuitable for food safety, and unsuitable for the food industry, and achieve the effects of no safety hazards, low production costs, and convenient use

Inactive Publication Date: 2013-09-18
徐志强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, L-tetrahydropalmatine is insoluble in water, slightly soluble in ethanol, and only soluble in dilute sulfuric acid. If it is dissolved in sulfuric acid and prepared into a solution, a certain amount of sulfuric acid must be transported and stored. Contains a large safety hazard, and the use of sulfuric acid to dissolve L-tetrahydropalmatine does not meet food safety and is not suitable for the food industry

Method used

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  • Dissolving method of L-tetrahydropalmatine, L-tetrahydropalmatine solution and application of L-tetrahydropalmatine solution
  • Dissolving method of L-tetrahydropalmatine, L-tetrahydropalmatine solution and application of L-tetrahydropalmatine solution
  • Dissolving method of L-tetrahydropalmatine, L-tetrahydropalmatine solution and application of L-tetrahydropalmatine solution

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Experimental program
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Effect test

Embodiment 1

[0038] In an environment protected from light and at room temperature, finely weigh 25g of L-tetrahydropalmatine, accounting for 35.71‰ of the weight of shredded tobacco, slowly add 100ml of water and stir evenly, and at the same time slowly add 30ml of phosphoric acid, continue to stir evenly, and it will appear uniform, clear, light yellow liquid, the liquid is evenly sprayed onto 700g of shredded tobacco and dried for later use. In each cigarette, the dosages of shredded tobacco and L-tetrahydropalmatine are 700mg and 25mg respectively. The shredded tobacco thus obtained is rolled and packaged according to the conventional preparation method in the field of cigarettes, and a cigarette capable of suppressing addicts' craving for drugs and preventing relapse can be obtained.

Embodiment 2

[0040] In an environment protected from light and at room temperature, finely weigh 20g of L-tetrahydropalmatine, accounting for 28.57‰ of the weight of shredded tobacco, slowly add 100ml of water and stir evenly, and at the same time slowly add 8ml of phosphoric acid, continue to stir evenly, and it will appear uniform, clear, light yellow liquid, the liquid is evenly sprayed onto 700g of shredded tobacco and dried for later use. In each cigarette, the dosages of shredded tobacco and L-tetrahydropalmatine are 700mg and 20mg respectively. The shredded tobacco thus obtained is rolled and packaged according to the conventional preparation method in the field of cigarettes, and a cigarette capable of suppressing addicts' craving for drugs and preventing relapse can be obtained.

Embodiment 3

[0042] In an environment protected from light and at room temperature, finely weigh 15g of L-tetrahydropalmatine, accounting for 21.43‰ of the weight of shredded tobacco, slowly add 100ml of water and stir evenly, and at the same time slowly add 10ml of phosphoric acid, continue to stir evenly, and it will appear uniform, clear, light yellow liquid, the liquid is evenly sprayed onto 700g of shredded tobacco and dried for later use. In each cigarette, the dosages of shredded tobacco and L-tetrahydropalmatine are 700mg and 15mg respectively. The shredded tobacco thus obtained is rolled and packaged according to the conventional preparation method in the field of cigarettes, and a cigarette capable of suppressing addicts' craving for drugs and preventing relapse can be obtained.

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Abstract

The invention provides a dissolving method of L-tetrahydropalmatine, an L-tetrahydropalmatine solution and an application of the solution. The dissolving method provided by the invention is characterized by steps of adding phosphoric acid into a water suspension of the L-tetrahydropalmatine to dissolve the suspended L-tetrahydropalmatine. The clear and flaxen L-tetrahydropalmatine solution, which is dissolved by using the water and the phosphoric acid, is uniformly sprayed on cut tobacco, or is uniformly mixed with other raw materials to obtain foods or beverages, therefore a drug abuser can accept the tobacco, food or beverage with pleasure, and simultaneously, the application of the phosphoric acid to the food addition and the production of the tobacco or other edible products better comply with human health and meets national laws on food safety and health.

Description

technical field [0001] The invention belongs to the field of food and medicine, and relates to a method for dissolving L-tetrahydropalmatine, a L-tetrahydropalmatine solution and applications thereof. Background technique [0002] Along with the seriousness of this social problem of drug abuse, people are developing various drug rehabilitation and drugs and preparations to prevent addicts from relapse after drug withdrawal. L-tetrahydropalmatine (l-tetrahydropalmatine l-THP, or rotundine, also known as craniodynia), is a dopamine (DA) receptor blocker, after oral or intramuscular injection, in addition to analgesic effect, It also has a stabilizing effect, and the drug has been included in the national pharmacopoeia. Since 2005, some scholars have found that l-THP can block the discrimination effect of morphine and antagonize the behavioral sensitization effect of amphetamine. Show that it can reduce or inhibit the formation of mental dependence on morphine and amphetamine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01F1/00A24B15/38A61K31/4375A61K47/04A61K9/08A61P25/36A23G4/12A23G3/36A23L2/52
CPCA24B15/302A24B15/38A61P25/36
Inventor 吴鎏桢
Owner 徐志强
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