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Application of Kudingcha saponin D in preparation of pharmaceuticals

A technology of tea saponin and Kuding, applied in the application field of Kuding tea saponin D, can solve the problems of unsolved toxic and side effects, toxic effects, increased transaminase and the like

Active Publication Date: 2013-11-06
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term use of statins has obvious toxic effects on the liver and muscles, and at the same time leads to an increase in transaminases. A small number of users suffer from rhabdomyolysis and acute renal failure. Despite several generations of drug structure modification, the problem of toxic and side effects has not yet been resolved.

Method used

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  • Application of Kudingcha saponin D in preparation of pharmaceuticals
  • Application of Kudingcha saponin D in preparation of pharmaceuticals
  • Application of Kudingcha saponin D in preparation of pharmaceuticals

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: the effect of kudingcha saponin D

[0038] In this example, different experiments have proved that Kudingcha saponin D has a good effect in reducing blood fat and the like.

[0039] (1) Experimental materials and methods:

[0040] 1. Experimental animals

[0041] C57 / BL-ApoE- / - mice are from Peking University Health Science Center, animal qualification certificate number: SCXK Beijing 2006-0008, 6-8 weeks old, body weight 22±2g, male and female half and half, provided by the Department of Experimental Animal Science, Peking University Health Science Center supply. The rearing conditions included temperature: 20±2°C; humidity: 60±5%; 12-hour light and dark cycle; free access to water.

[0042] 2. Test grouping and administration

[0043] ApoE- / - mice were randomly divided into 5 groups according to body weight.

[0044] (1) High-fat control group (HG): fed a high-fat diet supplemented with 0.2% cholesterol and 5% lard for 5 weeks, and administered no...

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PUM

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Abstract

The invention provides application of Kudingcha saponin D represented by formula (I) as described in the specification in preparation of pharmaceuticals, especially application of the Kudingcha saponin D in preparation of drugs used for preventing and / or treating diseases and / or symptoms caused by dyslipidemia.

Description

technical field [0001] The invention belongs to the technical field of pharmacy. Specifically, the present invention relates to the application of Kudingcha saponin D. Background technique [0002] Hyperlipidemia mainly includes hypercholesterolemia and hypertriglyceridemia, and the former is far more harmful than the latter. For hyperlipidemia, drug-induced lipid-lowering therapy is the most effective measure for treating hyperlipidemia. At present, there are many effective drugs for lowering triglycerides, but the effective drugs for lowering cholesterol are still mainly statins. This type of drug mainly fights arteriosclerosis caused by hypercholesterolemia, and its mechanism of action is to inhibit the synthesis of cholesterol in the liver. However, long-term use of statins has obvious toxic effects on the liver and muscles, and at the same time leads to an increase in transaminases. A small number of users suffer from rhabdomyolysis and acute renal failure. Despite s...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P3/06A61P9/10A61P13/12
Inventor 屠鹏飞姜勇郑姣车彦云马治中
Owner PEKING UNIV
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