Use of low-molecular weight oligomannuronate in preparation of drug or health care product for preventing or treating Parkinson's disease

Abstract

The invention provides a use of low-molecular weight oligomannuronate in preparation of a drug or a health care product for preventing or treating Parkinson's disease. According to the invention, marine acidic polysaccharose as a raw material is prepared into a water-soluble low-molecular weight mannuronic acid compound. An experiment proves that the low-molecular weight mannuronic acid can be used for preventing and treating or improving Parkinson's disease, has obvious pharmacological effects and no toxic or side effects on nerve cells and can be taken for a long time. The low-molecular weight mannuronic acid is a marine natural product, has the advantages of rich resources, easy industrialization, high safety, unique structure and good oral absorption, and has a wide market application prospect in prevention and treatment of Parkinson's disease.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of a low-molecular-weight mannuronic acid oligosaccharide in the preparation of medicines or health products for preventing or treating Parkinson's disease. Background technique [0002] Parkinson's disease (PD) is a degenerative disease of the central nervous system. According to statistics, the number of patients with Parkinson's disease in my country was 0.47% in 1984, and it rose to 1.4% in 2000. The latest national statistics are 1.7 million, and it is estimated that about 100,000 new PD patients will be added every year. This proportion is higher in rural areas. The incidence rate is about 2-3‰, and it shows a clear upward trend. [0003] Parkinson's disease is more common in the elderly, about 50% of people develop after the age of 60, and the other 50% develop before the age of 60, and some patients even develop around the age of 40. Tremors, limb stif...

AI Technical Summary

Problems solved by technology

Although there was a Chinese invention patent (application number 2004100238270; 2005800093965) that disclosed the application of low molecular weight alginate with a carboxyl group at the first position of the reducing end in anti-dementia and diabetes, and our research team (patent application number CN00111363.1) disclosed The preparation method of the guluronic acid of single degree of polymerization and its application in antitumor, but at present, there is no report about the application of low molecular weight mannuronic acid oligosaccharide in the prevention and treatment of Parkinson's disease, the compound of the present invention has The advantages of low molecular weight acid oligosaccharides are not only strong water solubility and easy absorption, but also abundant sources and unique mechanism of action, which have broad prospects for industrial development and application

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