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Use of low-molecular weight oligomannuronate in preparation of drug or health care product for preventing or treating Parkinson's disease

A technology of uronic acid oligosaccharide and mannuronic acid, which is applied in the field of medicine and achieves the effects of no toxic and side effects, high safety and easy industrialization

Active Publication Date: 2013-11-27
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although there was a Chinese invention patent (application number 2004100238270; 2005800093965) that disclosed the application of low molecular weight alginate with a carboxyl group at the first position of the reducing end in anti-dementia and diabetes, and our research team (patent application number CN00111363.1) disclosed The preparation method of the guluronic acid of single degree of polymerization and its application in antitumor, but at present, there is no report about the application of low molecular weight mannuronic acid oligosaccharide in the prevention and treatment of Parkinson's disease, the compound of the present invention has The advantages of low molecular weight acid oligosaccharides are not only strong water solubility and easy absorption, but also abundant sources and unique mechanism of action, which have broad prospects for industrial development and application

Method used

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  • Use of low-molecular weight oligomannuronate in preparation of drug or health care product for preventing or treating Parkinson's disease
  • Use of low-molecular weight oligomannuronate in preparation of drug or health care product for preventing or treating Parkinson's disease
  • Use of low-molecular weight oligomannuronate in preparation of drug or health care product for preventing or treating Parkinson's disease

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Embodiment 1

[0025] The invention provides the use of a low-molecular-weight mannuronic acid oligosaccharide for preparing preparations for preventing, treating or improving Parkinson's disease, or health care products. The present invention proves for the first time through experiments that low-molecular-weight mannuronic acid can effectively protect nerve cell mitochondrial damage, significantly inhibit the expression and deposition of Parkinson's disease α-synuclein characteristic protein, and therefore can be used to prevent, treat or improve Parkinson's disease.

[0026] The experimental method that does not indicate specific conditions in the following examples, generally according to conventional conditions such as Sambrook et al., molecular cloning: the conditions described in the laboratory guide (New York: Cold Spring Harbor Laboratory Press, 1989), or according to the manufacturer suggested conditions.

[0027] Unless otherwise defined, all professional and scientific terms used...

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Abstract

The invention provides a use of low-molecular weight oligomannuronate in preparation of a drug or a health care product for preventing or treating Parkinson's disease. According to the invention, marine acidic polysaccharose as a raw material is prepared into a water-soluble low-molecular weight mannuronic acid compound. An experiment proves that the low-molecular weight mannuronic acid can be used for preventing and treating or improving Parkinson's disease, has obvious pharmacological effects and no toxic or side effects on nerve cells and can be taken for a long time. The low-molecular weight mannuronic acid is a marine natural product, has the advantages of rich resources, easy industrialization, high safety, unique structure and good oral absorption, and has a wide market application prospect in prevention and treatment of Parkinson's disease.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of a low-molecular-weight mannuronic acid oligosaccharide in the preparation of medicines or health products for preventing or treating Parkinson's disease. Background technique [0002] Parkinson's disease (PD) is a degenerative disease of the central nervous system. According to statistics, the number of patients with Parkinson's disease in my country was 0.47% in 1984, and it rose to 1.4% in 2000. The latest national statistics are 1.7 million, and it is estimated that about 100,000 new PD patients will be added every year. This proportion is higher in rural areas. The incidence rate is about 2-3‰, and it shows a clear upward trend. [0003] Parkinson's disease is more common in the elderly, about 50% of people develop after the age of 60, and the other 50% develop before the age of 60, and some patients even develop around the age of 40. Tremors, limb stif...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K31/702A61P25/16A23L1/09A23L33/125
Inventor 于广利郝杰杰管华诗
Owner OCEAN UNIV OF CHINA
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