Optical coherence tomography method and device based on radially polarized beams

Abstract

The invention provides an optical coherence tomography method and device based on radial-direction polarized beams. The method comprises the following steps that after light beams emitted by a low-coherence light source are processed through a Kohler illumination system, the polarization state of the light beams is adjusted and controlled through a polarization transformation system, the amplitude and phase distribution of the light beams are adjusted and controlled through a pupil filter, and accordingly the radial-direction light beams are formed; the radial-direction polarized beams enter a beam splitter prism in an incident mode, are divided into two paths, and enter a sample arm and a reference arm respectively; the two-path light beams are focused on a sample to be measured and a reference plane mirror through microscope objectives of the two-path light beams respectively; returned light after being reflected by the sample to be measured and the reference plane mirror joins in the position of the beam splitter prism, is focused through a focusing lens, is imaged in a probe and is then transmitted to a computer to be post-processed; the reference plane mirror transversely moves to achieve transverse scanning; the sample to be measured is placed on a three-dimensional horizontal-moving table capable of moving in space to achieve three-dimensional imaging of the sample.

Description

technical field [0001] The invention relates to optical coherence tomography technology, in particular to a super-resolution optical coherence tomography method and device using radially polarized light beams. Background technique [0002] Optical coherence tomography (Optical Coherence Tomography, OCT) is another new tomographic imaging technology after X-ray, CT, magnetic resonance imaging (MRI), and ultrasonic diagnostic technology. Compared with conventional medical imaging methods, it has higher sensitivity and resolution. It can realize non-destructive, non-invasive, non-ionizing radiation, micron-scale structural imaging of biological tissues and functional imaging such as polarized OCT, Doppler OCT, spectral OCT, elastic OCT, etc., and is used for microstructural analysis of living biological tissues It has been widely used in biomedicine (ophthalmology, dermatology, cardiovascular system, digestive system and traditional Chinese medicine, etc.) and many other field...

AI Technical Summary

Problems solved by technology

It can be seen that increasing the numerical aperture of the microscope objective lens can reduce the size of the spot of the probe beam at the focal point, but at the same time, it also reduces the size of the depth of focus

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