Methods for activating caspase-14 expression in human skin

Abstract

One or more extracts selected from the group consisting of litchi, glasswort, peach, soja seed, sweet basil, cucumber, chanterelle, leek, kiwi fruit, rhubarb, grapefruit, wheat, raspberry, plum, and mixtures thereof, in a dermatologically acceptable carrier for use in topically treating caspase-14 deficiency in human skin.

Description

technical field [0001] The present invention relates to formulations and methods for improving the hydration characteristics of skin. In particular, the formulations and methods herein relate to the activation of caspase-14 expression in human skin. Background technique [0002] Skin undergoes deterioration over time (aging), skin disease, hormonal changes, environmental abuse (wind, air conditioning, heat, pollution, etc.), all of which can be caused by exposing the skin to the sun Accelerated by light radiation (photoaging). Consumers increasingly seek "anti-aging" cosmetics that treat or delay the visible signs of age-related and photoaging skin, such as wrinkles, creases, sagging, hyperpigmentation, and age spots. Cellulite also manifests as a consequence of increased adipogenicity and decreased connective tissue matrix. [0003] Caspase-14 is a unique protease that controls epidermal maturation. This control results from the proteolytic processing of filaggrin, a pr...

AI Technical Summary

Problems solved by technology

Although many cosmetic compositions currently on the market are designed to treat signs of aging, none of the products and treatments target improved caspase-14 expression

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