Composition for rescuing from collapse by restoring yang and preventing and curing chronic heart failure, medicament prepared from composition and preparation method of composition

Abstract

The invention discloses a composition for rescuing from collapse by restoring yang and preventing and curing chronic heart failure, a medicament prepared from the composition and a preparation method of the composition. The composition is composed of a ginsenoside extract, a monkshood extract containing no diester-type alkaloids and a rhizoma zingiberis extract, wherein the proportion of parts by weight of the extraction raw materials of ginseng or red ginseng to monkshood to rhizoma zingiberis is 1: (1-5): (1-5). In aspects of rescuing from collapse by restoring yang, curing chronic heart failure and cardio-pulmonary-cerebral resuscitation and the like, the composition can not only generate an obvious synergistic effect, and the toxicity of the composition is obviously lower than that of a composition extracted from common monkshood through such extraction manners as acid water, water or alcohol, so that the compatibility of effective components is relatively reasonable and safe. With the composition as an effective component, pharmaceutically acceptable additives can be combined to form an oral medicament preparation having the functions of rescuing from collapse by restoring yang and preventing and curing chronic heart failure.

Description

technical field [0001] The invention relates to a composition of natural medicinal ingredients, in particular to a composition with functions of restoring yang and rescuing kidneys and preventing and treating chronic heart failure, a corresponding medicine and a preparation method. Background technique [0002] Aconite is an important medicinal material that has the functions of recovering yang and rescuing the adversity, replenishing fire and supporting yang. At the same time, aconitine is also a poisonous traditional Chinese medicine, and the main highly toxic components are diester-type alkaloids (aconitine, neoaconitine, hypoaconitine). The active ingredients of aconite for recovering yang and resuscitation are still unclear. It has been reported that aconitine, hypoaconitine, noraconitine, methyldopamine chloride, norsiginaline, Water-soluble components such as uracil and aconite have cardiotonic and / or pressor effects. Ancient prescriptions with aconite as the ma...

AI Technical Summary

Problems solved by technology

Publication No. CN102552861A Chinese patent reports the extraction process of Ginseng Sini Granules, which is composed of ginseng, aconite, licorice, and dried ginger. Because the main active ingredient of licorice is glycyrrhizic acid, it has a similar effect to the human adrenal cortex hormone aldosterone. / Large doses can cause "pseudoaldosteronism", decreased urine output and increased water storage in the body leading to edema, excessive sodium storage in the body causing high blood pressure, excessive blood potassium loss causing hypokalemia, leading to arrhythmia , so long-term use has adverse negative effects on patients with chronic heart failure

The applicant has made in-depth research and found that due to the characteristics of the medicinal raw material aconite (prepared aconite and / or raw aconite), especially the prepared aconite, after being decocted in ordinary water in a conventional manner, the decoction is acidic or even strong Acidic, so the diester-type alkaloids in the water decoction are relatively stable. Even if it is decocted for a long time, not only the detoxification effect is not ideal, but also the loss of beneficial ingredients is easy to occur

Because diester alkaloids have obvious cardiotoxicity, these aconite compositions containing diester alkaloids have certain toxicity and potential safety hazards, which also affect the efficacy and safety of drugs

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