A method for preparing Hovenia dulcis fruit extract by semi-bionic extraction technology

The technology of Fructus Aurantii and its extracts is applied in the directions of pharmaceutical formulations, plant raw materials, medical preparations containing active ingredients, etc. It can solve the problems of incomplete extraction of active ingredients, low oral bioavailability, waste of resources, etc. The application effect is good, the cost is low, and the quality is guaranteed.

Active Publication Date: 2015-08-05
哈药集团中药有限公司
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  • Summary
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  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problems of incomplete extraction of active ingredients, low extraction rate, low oral bioavailability, waste of resources and high cost in the existing Hovenia dulcis fruit extract, and to provide a semi-bionic extraction technology to prepare Hovenia dulcis Preparation method of sub-extract

Method used

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Comparison scheme
Effect test

specific Embodiment approach 1

[0023] Specific embodiment one: a kind of semi-bionic extraction technique of the present embodiment prepares the method for the Hovenia dulcis fruit extract is to carry out according to the following steps:

[0024] 1. Purification: take Hovenia dulcis medicinal materials and remove impurities;

[0025] 2. Weighing: Weigh 1,000 to 3,000 parts of Hovenia dulcis L., 0.01 to 0.03 parts of sodium hydroxide and 4 to 6 parts of hydrochloric acid in parts by mass;

[0026] 3. Pulverization: pulverize the Hovenia dulcis fruit taken in step 2 into 10-40 orders to obtain the raw powder of medicinal material;

[0027] Four, preparation solution: the hydrochloric acid weighed in step 2 is mixed with the acid solution that pH value is 1.0~3.0 with the purified water of 1000~5000 parts by weight; The sodium hydroxide weighed in step 2 is 1000 parts by weight ~5000 parts of purified water is prepared into an alkaline solution with a pH value of 9.0~11.0;

[0028] 5. Extraction:

[0029] ...

specific Embodiment approach 2

[0042] Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is that the pH value of the acid solution described in step 4 is 2.0, and the pH value of the alkali solution is adjusted to 10.0. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0043] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the acid solution extraction, purified water extraction and alkali solution extraction steps described in step 5 are all extracted by a closed reflux system. Others are the same as in the first or second embodiment.

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Abstract

A semen hoveniae extract preparation method adopting the semi-bionic extraction technology relates to the extraction and preparation method for extracts of semen hoveniae which is a traditional Chinese medicine, and aims to solve the problems of the conventional semen hoveniae extracts such as incomplete extraction of effective ingredients, low extraction rate and oral bioavailability, as well as high resource waste and cost. The semen hoveniae extract preparation method includes the following steps: 1. the medicinal material semen hoveniae is cleansed; 2. the medicinal material, extraction solvent, and acid and alkali are weighed; 3. the medicinal material is pulverized; 4. extraction solutions are prepared; 5. semen hoveniae is extracted according to the semi-bionic technology; 6. medicine liquids are concentrated; 7. liquid extracts are dried for extraction; 8. the dry extracts are pulverized by airflows and sieved through a 120-mesh sieve; 9. the dry extract powders are uniformly mixed to obtain semen hoveniae extracts. The semen hoveniae extracts prepared by the method has high potency and oral bioavailability, and pharmacodynamic tests prove the semen hoveniae extracts have good hangover alleviation and liver protection effects; during the preparation, the production process is simple and dispenses with special production equipment. The preparation method disclosed by the invention is applicable to the field of preparation for extracts of traditional Chinese medicines and natural medicines.

Description

technical field [0001] The invention relates to a preparation method in the field of extracts of traditional Chinese medicines and natural medicines. Background technique [0002] Hovenia dulcis has the effects of promoting body fluid and quenching thirst, sobering up, diuresis, and protecting the liver. It is used for drunkenness, chemical liver injury, and diabetes, and has a wide range of clinical treatment and health care applications. However, because Hovenia dulcis is a seed medicinal material, it must be crushed before extraction, which is inconvenient for clinical use; if the medicinal material is broken first, it will easily oxidize and deteriorate during transportation and storage due to the fact that it contains a lot of unsaturated fatty acids. However, most of the existing methods for preparing Hovenia dulcis extract are water extraction, ethanol, or organic solvent extraction. The method of water extraction alone cannot completely extract the biologically acti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/72
Inventor 刘景国柳松林钮旭生谢明李文军郑玥肇静静尹涛裴福成单钰毓李殿明王英新
Owner 哈药集团中药有限公司
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