Application of kin17 gene or protein in preparation of medicament for diagnosis and treatment of cervical cancer

A technology for cervical cancer and protein expression, applied in the field of new diagnostic markers and drug targets for cervical cancer

Active Publication Date: 2016-09-14
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no reports on the new diagnostic markers and drug targets of Kin17 gene or protein cervical cancer

Method used

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  • Application of kin17 gene or protein in preparation of medicament for diagnosis and treatment of cervical cancer
  • Application of kin17 gene or protein in preparation of medicament for diagnosis and treatment of cervical cancer
  • Application of kin17 gene or protein in preparation of medicament for diagnosis and treatment of cervical cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0012] The designation and sequence of Kin17 gene or protein

[0013] The gene encoding the Kin17 protein is named "KIN17 gene", the protein encoded by the KIN17 gene is named "Kin17 protein", and the accession number of the KIN17 gene is: NM_012311.

[0014] The nucleotide sequence of the KIN17 gene is shown in SEQ ID NO:1.

[0015] The amino acid sequence of Kin17 protein is shown in SEQ ID NO:2.

[0016] The present invention will be further described below in conjunction with specific experiments, but not limited thereto.

[0017] Kin17 gene or protein is used in the diagnosis of cervical cancer:

[0018] Cervical cancer tissue is formed by malignant changes and uncontrolled proliferation of normal cervical epithelial cells. The present inventor detected the expression of Kin17 in 129 cervical biopsy specimens by immunohistochemical method, including 27 specimens of benign cervical lesions (including chronic cervicitis, cervical dysplasia and cervical intraepithelial ne...

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Abstract

The invention discloses a use of a Kin17 gene or protein in preparation of cervical cancer diagnosis and treatment medicaments. The inventor discoveries that an expression level of the Kin17 protein in normal cervical epithelial tissue and cervical benign lesion tissue cells is low but the expression level is high in cervical cancer tissue and thus the Kin17 protein keeps rapid proliferation activity of cervical cancer cells, is closely related to pathological parameters, chemotherapeutic effects and disease progress and has an important effect in cervical cancer generation and development. Through silencing of Kin17 expression in cervical cancer cells, cancer cell proliferation activity is inhibited and cervical cancer cell sensitivity to chemotherapeutic drugs is improved. The Kin17 gene or protein can be used as a novel cervical cancer diagnosis marker and medicament target. The Kin17 gene or protein can be used for cervical cancer early-identification diagnosis, patient prognosis evaluation and clinical treatment.

Description

technical field [0001] The invention relates to new diagnostic markers and drug targets of cervical cancer, in particular to the application of Kin17 gene or protein in preparation of cervical cancer diagnosis, prognosis evaluation and therapeutic agents. Background technique [0002] Cervical cancer is one of the most common malignant tumors in women. In 2012, the incidence rate of cervical cancer in my country was 12.96 / 100,000, accounting for 5.12% of all female tumors, which seriously threatened the life and health of Chinese women. Cervical intraepithelial neoplasia and early invasive carcinoma under the microscope are generally asymptomatic, and patients with cervical cancer generally have invasive carcinoma after the typical symptoms appear. After effective treatment such as surgery and chemotherapy, 80% of patients with stage I and stage II cervical cancer can obtain significant curative effect. Early screening and early diagnosis and treatment are crucial to the p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/68G01N33/68G01N33/574A61K45/00A61K39/395A61P35/00
CPCA61K39/3955A61K45/00C12Q1/6886C12Q2600/106C12Q2600/118C12Q2600/158
Inventor 曾涛
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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