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Schisandra extract for treating cough and alleviating airway inflammation, its preparation method and application

A technology of Schisandra chinensis extract and airway inflammation, which is applied in the fields of medical preparations containing active ingredients, food science, drug combination, etc., can solve the problems of coughing with Schisandra chinensis extract that have not been reported in the literature, and achieves easy promotion, solvent safety and no Poison, simple preparation method

Active Publication Date: 2016-08-03
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT) +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there has been no literature report whether Schisandra extract can effectively treat cough, especially chronic cough

Method used

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  • Schisandra extract for treating cough and alleviating airway inflammation, its preparation method and application
  • Schisandra extract for treating cough and alleviating airway inflammation, its preparation method and application
  • Schisandra extract for treating cough and alleviating airway inflammation, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Dry Schisandra chinensis medicinal material 10kg, pulverize into 30 mesh coarse powder, reflux extract with 95% (v / v) ethanol 3 times, each time 3h, the volume (ml) of ethanol used for three extractions is 8 times of medicinal material quality (g) respectively. times, 6 times, and 6 times, combined the extracts for 3 times, filtered after standing, and concentrated under reduced pressure to obtain extract A; decoct the dregs left after extraction with water twice, 2 hours each time, decocting twice The required volume of water (ml) is 8 times and 6 times of the mass (g) of Schisandra chinensis, respectively. The two extracts are combined, filtered after standing, and concentrated under reduced pressure to obtain extract B. The extracts A and B were combined and vacuum-dried to obtain 5.69 kg of Schisandra chinensis extract.

Embodiment 2

[0023] 10 kg of dried Schisandra chinensis medicinal material was crushed into 40 mesh coarse powder, 80% (v / v) ethanol aqueous solution was refluxed and extracted 3 times, each time for 3 hours, and the volumes (ml) of ethanol extracted three times were respectively 8 times of the mass (g) of Schisandra chinensis medicinal material. times, 6 times, and 6 times, combined the extracts for 3 times, filtered after standing, and concentrated under reduced pressure to obtain extract A; the dregs left after extraction were decocted twice, each time for 2 hours, decocting water twice The volume (ml) of the schisandra medicinal material (g) was 8 times and 6 times respectively, the two extracts were combined, filtered after standing, and concentrated under reduced pressure to obtain extract B. The extracts A and B were combined and vacuum-dried to obtain 5.28 kg of Schisandra chinensis extract.

Embodiment 3

[0025] Dry Schisandra chinensis 10kg, crushed into 50 mesh coarse powder, 60% (v / v) ethanol aqueous solution reflux extraction 2 times, each time 3h, the volume (ml) of twice extracted ethanol is respectively the quality of Schisandra chinensis medicinal material (g) 8 times and 6 times of that, combined the extracts, filtered after standing, and concentrated under reduced pressure to obtain extract A; the dregs left by the extraction were decocted twice, each time for 2 hours, and the volume of the twice decocted water (ml ) were 8 times and 6 times the mass (g) of Schisandra chinensis, respectively, the extracts were combined, filtered after standing, and concentrated under reduced pressure to obtain extract B. The extracts A and B were combined and vacuum-dried to obtain 5.42 kg of Schisandra chinensis extract.

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PUM

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Abstract

Disclosed are a schisandra extract and a preparation method thereof, and a use in the preparation of drugs or health care products for treating coughs and alleviating airway inflammations. The preparation method comprises the steps of using schisandra as a raw material, carrying out reflux extraction three times by using ethanol, mixing the extracting solutions, and filtering after standing to obtain an extract A, wherein each extraction operation lasts for 1-3 h; decocting dregs in water three times, mixing the extracting solutions, and filtering after standing to obtain an extract B, wherein each decoction operation lasts for 1-3 h; and mixing the extracts A and B, and carrying out vacuum drying to obtain the schisandra extract.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract, in particular to a Schisandra chinensis extract and its preparation method and application, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Cough is the most common symptom in medical clinics, and it is seen in a variety of respiratory and non-respiratory diseases. Coughing itself is a defense mechanism to clear excess secretions in the airways and prevent aspiration of foreign matter into the airways. However, chronic cough that lasts for a long time seriously affects the quality of life of patients and causes a serious psychological burden on patients, and also significantly increases personal and public health care expenditures. Clinically, chronic cough refers to the cough as the only symptom or the main symptom, the cough lasts for more than 8 weeks, and there is no obvious abnormality in chest X-ray examination. According to a survey...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/79A61K36/57A23L33/00A61P11/14A61P11/00
CPCA61K36/57A61K36/79
Inventor 赖克方钟山甘振勇刘晓东聂怡初钟南山
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT)
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