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Pharmaceutical composition for treating asthma

A composition and drug technology, applied in the field of medicine, can solve the problem that the recurrence of patients is not ideally controlled

Inactive Publication Date: 2017-08-18
牛永友
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional method of treating asthma is the use of glucocorticoids and bronchodilators. However, the recurrence of patients is still not ideally controlled. Therefore, it is urgent to develop effective therapeutic drugs

Method used

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  • Pharmaceutical composition for treating asthma
  • Pharmaceutical composition for treating asthma
  • Pharmaceutical composition for treating asthma

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0021] The characterization of experimental example 1 medicine of the present invention

[0022]

[0023] 1 H NMR (CDCl 3 )δ: 7.24(1H,d), 6.89(1H,d), 4.44(1H,d), 4.40(1H,d), 4.36(1H,d), 3.89(3H,s), 3.87(1H,d ), 3.31(3H,s), 1.98(1H,m), 1.74(1H,m), 1.10(1H,m), 1.04(1H,m).

experiment example 2

[0024] Experimental example 2 the effect of medicine treatment asthma of the present invention

[0025] Grouping and Model Building

[0026] All mice were divided into normal control group, model control group, drug group of the present invention and dexamethasone group according to the random number table method, with 10 mice in each group. Except for the normal group, 0.2 mL of the sensitizing solution was injected intraperitoneally on the 1st and 14th day for sensitization, and on the 14th, 25th, 26th, and 27th day, after intraperitoneal injection of pentobarbital sodium for anesthesia, 0.05 mL of the stimulating solution was given nasal drops excitation. On the 28th~41 days, the model control group gave 0.9% sodium chloride solution 0.5mL for intragastric administration, the drug group of the present invention gave embodiment 1 medicine 10mg / kg for intragastric administration, and the dexamethasone group intraperitoneally injected dexamethasone 0.5mL (1mg / kg). kg). The ...

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Abstract

In order to alleviate the airway inflammatory response of asthma patients, the invention discloses a pharmaceutical composition for treating asthma. The pharmaceutical composition uses the compound with the innovative structure of the following formula as an active ingredient: The medicament of the invention has good effects in alleviating airway inflammatory response of asthma patients, inhibiting asthma and improving lung function, and is expected to be developed into a medicament for treating asthma in clinical application.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to a pharmaceutical composition for treating asthma and the application of the compound in preparing medicine for treating asthma. Background technique [0002] Asthma is a chronic inflammatory disease of the airways in which many cells in the innate and acquired immune systems, together with epithelial cells, cause bronchial hyperresponsiveness, mucus overproduction, airway inflammatory cell infiltration, airway remodeling, and airway narrowing . The traditional method of treating asthma is the use of glucocorticoids and bronchodilators. However, the recurrence of patients is still not well controlled. Therefore, it is urgent to develop effective therapeutic drugs. Contents of the invention [0003] The object of the present invention is to provide a pharmaceutical composition for treating asthma. [0004] In order to realize the purpose of the present invention, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/94A61K31/352A61P11/06
CPCC07D311/94A61K31/352
Inventor 牛永友
Owner 牛永友
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