Method for evaluating albumin leakage quantity from blood purifier

An evaluation method and blood purification technology, which is applied in the field of evaluation of albumin leakage of blood purifiers, can solve the problems of high permeability of blood purifiers, excessive leakage of albumin to the outside of the body, etc.

Active Publication Date: 2014-12-17
ASAHI KASEI MEDICAL CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Blood purification therapy based on high-permeability blood purifiers can alleviate the aforementioned symptoms of dialysis patients. On the other hand, due to the high permeability of blood purifiers, albumin that is useful to the body is excessively leaked out of the body during treatment. risks of

Method used

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  • Method for evaluating albumin leakage quantity from blood purifier
  • Method for evaluating albumin leakage quantity from blood purifier
  • Method for evaluating albumin leakage quantity from blood purifier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0239] Collect clinical information during dialysis treatment of 24 cases, such as image 3 summarized as shown. The membrane material of the blood purifier used is polysulfone. Here, the PVP-K30 screening coefficient means that PVP-K30 is dissolved in 1 / 15M phosphate buffer solution (pH7.0) in such a way as to reach 3%, and the resulting solution is dissolved at a linear velocity of 1 [cm / s] Sieving coefficient when 20 minutes have elapsed while filtering while applying TMP200 [mmHg] while flowing inside the hollow fiber membrane. The concentration of PVP-K30 was measured using the absorbance at 220 [nm].

[0240] Depend on image 3 The clinical information was derived in one step to calculate the regression formula for the calculated value (Q) of albumin leakage.

[0241] In the case where the parameters used in the regression formula are the water removal rate and the PVP-K30 screening coefficient of the hollow fiber membrane, the regression formula is:

[0242] Q=-22....

Embodiment 2

[0254] In order to use the same clinical information as in Example 1 to make a regression formula that calculates the amount of albumin leakage (Q) with a quadratic formula, such as Figure 5 Summarized clinical information shown.

[0255] Depend on Figure 5 A regression equation for calculating the calculated value (Q) of albumin leakage was prepared using the clinical information of the quadratic equation. The created regression equation (13) is shown below.

[0256] Q=62.95-0.30×(patient’s hematocrit value before treatment)+4.65×10 -3 ×(Patient's hematocrit value before treatment) 2 +2.35×10 -4 ×(water removal)+1.53×10 -8 ×(water removal) 2 +9.2×10 -6 ×(blood flow) 2 +10.18×(membrane area)-2.38×(membrane area) 2 -236.40×(PVP-K30 screening coefficient)+200.95×(PVP-K30 screening coefficient) 2 ...(13)

[0257] The correlation coefficient R at this time 2 is 0.97.

[0258] From this result, it can be considered that the quadratic regression formula can better pre...

Embodiment 3

[0261] Using the same clinical information as in Example 1, a regression expression was created for the parameter excluding the membrane area. The created regression equation (14) is shown below.

[0262] Q=-26.01+2.64×10 -2 ×(Patient’s hematocrit value before treatment)+6.74×10 -4 ×(water removal)+5.14×10 -3 ×(blood flow)+36.32×(PVP-K30 screening coefficient)…(14)

[0263] The correlation coefficient R at this time 2 is 0.92.

[0264] Comparing Equation (12) and Equation (14) yielded the following result: the correlation coefficient decreases when the parameter of membrane area is removed, so it is better not to remove the parameter of membrane area in order to predict the amount of albumin leakage.

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Abstract

Provided is an evaluation method for calculating the quantity of albumin leaking from a blood purifier before purifying the blood of a patient to be treated by using a hollow fiber membrane bundle. Also provided is an evaluation method for calculating values that relate to blood purification conditions and the properties of a blood purifier so as to attain the target albumin leakage quantity. Using statistical procedures, a regression equation for calculating albumin leakage quantity is derived at least on the basis of a first parameter that relates to the blood properties of the subject, a second parameter that relates to the conditions for the purification of the subject's blood, a third parameter that relates to the properties of the blood purifier and the albumin leakage quantity. Then, the quantify of albumin leaking from the blood purifier, said blood purifier being used by the patient to be treated, is calculated using this regression equation. Alternatively, a second parameter and a third parameter that allow the achievement of the target albumin leakage quantity are calculated.

Description

technical field [0001] The present invention relates to a method, program, device and package for evaluating albumin leakage of a blood purifier before purifying blood using the blood purifier; or before purifying blood using a blood purifier An evaluation method, program, device, and package for calculating blood purification conditions and / or properties of a blood purifier for obtaining a target albumin leakage amount. Background technique [0002] Due to chronic renal failure diseases or complications of diabetes, etc., the number of patients who have to undergo dialysis treatment is increasing year by year. On the other hand, the dialysis treatment period of patients is prolonging due to dialysis technology, water quality management, and performance improvement of blood purifiers. It is well known in the dialysis industry that due to the long-term dialysis treatment period, various symptoms such as arthralgia or joint swelling, joint movement inhibition, and itchy skin ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/18B01D65/10
CPCB01D65/104
Inventor 关根久美子
Owner ASAHI KASEI MEDICAL CO LTD
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