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Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method thereof

A technology of diabetic nephropathy and composition, which is applied in the field of traditional Chinese medicine composition for treating diabetic nephropathy and its preparation, which can solve the problems of incomplete understanding and difficulties of diabetic nephropathy, and achieve the effects of improving edema and reducing urinary protein excretion rate

Active Publication Date: 2018-09-11
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the understanding of the basic pathogenesis of diabetic nephropathy is not completely consistent in different schools, the selection of prescriptions and medications also have their own characteristics. However, it is indeed difficult to deal with complex and changeable conditions with a fixed prescription.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Weigh raw materials according to the following weight: (kg)

[0086] Astragalus 27; Nepeta 7; Su Ye 9; Raw Burnet 9; Fried Sophora japonica 9;

[0087] Preparation:

[0088] Weigh 7 kg of nepeta and 9 kg of perilla leaves, mix them evenly, add distilled water 10 times the total weight of nepeta and perilla leaves, soak for 1 hour, use steam distillation method, extract at 75°C for 2 hours, and obtain nepeta and perilla volatile oil. The distilled aqueous solution is filtered, and the filtrate is concentrated to obtain the first filtrate. The volume of the first filtrate is 0.5 times the total volume before concentration, and it is used for later use; medicinal residues, astragalus 27kg, raw Burnet 9kg, fried Sophora japonica 9kg, Salvia miltiorrhiza 9kg, madder 9kg, Dabupi 9kg and rhubarb 2.5kg are decocted twice, the amount of water added for each decoction is 10 times of the total drug weight, and the time of decocting each time is 2h, and the decoction obtained twic...

Embodiment 2

[0091] Weigh raw materials according to the following weight: (kg)

[0092] Astragalus 20; Nepeta 10; Su Ye 5; Burnet 15; Fried Sophora japonica 5; Salvia miltiorrhiza 15; Rubia 5;

[0093] Preparation:

[0094] Weigh 10 kg of nepeta and 5 kg of perilla leaves, mix them evenly, add distilled water 10 times the total weight of nepeta and perilla leaves, soak for 1 hour, and extract by steam distillation at 75°C for 2 hours to obtain volatile oils of nepeta and perilla. Filtrate the distilled aqueous solution, concentrate the filtrate to obtain the first filtrate, the volume of the first filtrate is 0.4 times the total volume before concentration, and set aside; medicinal residues and astragalus 20kg, raw Burnet 15kg, fried Sophora japonica 5kg, Salvia miltiorrhiza 15kg, madder 5kg, 15kg of big belly skin and 1kg of rhubarb are decocted twice, the amount of water added for each decoction is 8 times of the total drug weight, and the time of each decoction is 1h, the decoction ob...

Embodiment 3

[0097] Weigh raw materials according to the following weight: (kg)

[0098] Astragalus 35; Nepeta 5; Su Ye 15; Burnet 5; Fried Sophora japonica 15;

[0099] Preparation:

[0100] Weigh 5 kg of nepeta and 15 kg of perilla leaves, mix them evenly, add 10 times the total weight of nepeta and perilla leaves in distilled water, soak for 1 hour, use steam distillation method, extract at 75°C for 2 hours, and obtain nepeta and perilla volatile oil. The distilled aqueous solution is filtered, and the filtrate is concentrated to obtain the first filtrate. The volume of the first filtrate is 0.6 times the total volume before concentration, and it is set aside; medicinal residues, astragalus 35kg, raw Burnet 5kg, fried Sophora japonica 15kg, Salvia miltiorrhiza 5kg, madder 15kg, 5kg of Dabupi and 5kg of rhubarb are decocted twice, and the amount of water added for each decoction is 12 times of the total drug weight, and the time of each decoction is 1.5h. After filtering, the filtrate ...

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Abstract

The invention discloses traditional Chinese medicine composition for treating diabetic nephropathy and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises bulk drugs in parts by weight as follows: 20-35 parts of milkvetch root, 5-10 parts of fineleaf schizonepeta herb, 5-15 parts of perilla leaf, 5-15 parts of raw sanguisorba root, 5-15 parts of stir-fried sophora flower, 5-15 parts of danshen root, 5-15 parts of india madder root, 5-15 parts of areca peel and 1-5 parts of rhubarb. The preparation method comprises steps as follows: extracting volatile oil of the fineleaf schizonepeta herb and the perilla leaf, filtering a distilled aqueous solution, and concentrating a filtrate to obtain a first filtrate; decocting dregs, the milkvetch root, the raw sanguisorba root, the stir-fried sophora flower, the danshen root, the india madder root, the areca peel and the rhubarb with water twice, merging and filtering decoctions, concentrating a filtrate, placing the filtrate to be at the room temperature to obtain a second filtrate, evenly mixing the first filtrate and the second filtrate to obtain a mixed liquid, adding ethyl alcohol, leaving the mixture to stand, drying the mixture to obtain an extract, adding starch, and finally, spraying the volatile oil of the fineleaf schizonepeta herb and the perilla leaf into the extract to obtain the traditional Chinese medicine composition. A formula of the traditional Chinese medicine composition is significant in effect on treating the diabetic nephropathy.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to a traditional Chinese medicine composition for treating diabetic nephropathy and a preparation method thereof. Background technique [0002] In the past 30 years, the incidence of diabetes in my country has continued to rise. Statistics in 2012 show that the prevalence of pre-diabetes has reached 16.5%, surpassing India to become the country with the largest number of diabetic patients. The "dual pressure" of the increase in the elderly population and the younger incidence of diabetes has made the prevention and control situation more severe. Diabetic nephropathy is the most common and serious complication of diabetes. It has become the main cause of death in diabetes and has seriously affected people's health. The main pathological changes of diabetic nephropathy are thickening of glomerular basement membrane and accumulation of extracellular matrix mainly in glomerular mesa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/889A61P3/10A61P13/12
CPCA61K9/1652A61K36/481A61K36/489A61K36/535A61K36/537A61K36/538A61K36/708A61K36/739A61K36/74A61K36/889A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 孟庆刚谢晴宇孟繁兴李妍
Owner BEIJING UNIV OF CHINESE MEDICINE
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