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Voglibose pharmaceutical preparation for preventing and treating diabetes and nephropathy

A technology for diabetic nephropathy and voglibose, applied in the field of medicine, can solve the problems of exacerbating the deterioration of diabetic nephropathy, aggravating the pathological damage of DN, overloading and accumulation, etc., achieving significant protective effect, low toxic side effects, and good tolerance Effect

Inactive Publication Date: 2015-09-16
白强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

3. High-protein diet aggravates the deterioration of diabetic nephropathy; diabetic patients strictly limit the intake of carbohydrates, and mainly rely on high-protein fiber food supply. pathological damage
Because the disease often requires long-term medication, the adverse reactions of long-term medication, the price of the drug, and the limitation of the course of treatment all affect the treatment of DN.

Method used

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  • Voglibose pharmaceutical preparation for preventing and treating diabetes and nephropathy
  • Voglibose pharmaceutical preparation for preventing and treating diabetes and nephropathy
  • Voglibose pharmaceutical preparation for preventing and treating diabetes and nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: the preparation of tablet

[0022]

[0023] Preparation Process:

[0024] (1) Pass voglibose and meloxicam through a 100-mesh sieve, and mix them evenly with sodium carboxymethyl starch and lactose;

[0025] (2) Add an appropriate amount of 50% ethanol solution to the powder in step (1), wet granulate, dry at 50°C, and pass the dry granules through a 20-mesh sieve;

[0026] (3) Mix the dry granules with magnesium stearate evenly, and press into tablets.

Embodiment 2

[0027] Example 2: Study on the renal protective effect of voglibose combined with meloxicam on mice with diabetic nephropathy

[0028] Clean-grade healthy db / db mice aged 6-7 weeks were housed in separate cages, 4 mice per cage, and the room temperature was kept at about 21°C with good ventilation. During the experiment period, the mice had free access to food and water. Tail vein blood glucose and urine sugar were measured after the mice were fed for 1 week, and the blood glucose of db / db mice was >16.7mmol / L, and the urine sugar was 3+~4+, suggesting that the diabetes model could be used in the experiment. The db / db mice were randomly divided into 4 groups, 6 mice in each group, and treated for 16 weeks. details as follows:

[0029] (1) Model control group, intragastric administration of equal volume of normal saline;

[0030] (2) In the voglibose group, voglibose 0.5 mg / kg was administered orally according to body weight;

[0031] (3) In the meloxicam group, 3.0 mg / kg o...

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Abstract

The invention belongs to the technical field of medicines, and discloses a pharmaceutical preparation for preventing and treating diabetes and nephropathy, wherein the pharmaceutical preparation contains voglibose and meloxicam. The pharmaceutical preparation disclosed by the invention is composed of active components including voglibose and meloxicam; furthermore, the two active components can be used for synergistically treating diabetic complications and particularly has the very obvious protective effect on renal functions; and therefore, the pharmaceutical preparation is applied to preventing and treating diabetes and nephropathy.

Description

technical field [0001] The invention relates to a medicine for anti-diabetic complications, in particular to a voglibose pharmaceutical preparation for preventing and treating diabetic nephropathy, which belongs to the technical field of medicine. Background technique [0002] Diabetic nephropathy (diabetic nephropathy, DN) is glomerulosclerosis caused by diabetic microangiopathy, is one of the main complications of diabetes mellitus (DM), and is also one of the common causes of death in DM. The clinical features of the disease are proteinuria, progressive renal damage, hypertension, edema, and severe renal failure in the late stage, and it is one of the main causes of death in diabetic patients. In recent years, with the prolongation of the average life expectancy of the Chinese population, changes in living and eating habits, and structural changes, the prevalence of diabetes has shown a linear upward trend, and due to the improvement of treatment methods, the survival tim...

Claims

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Application Information

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IPC IPC(8): A61K31/5415A61P3/10A61P13/12A61K31/133
Inventor 白强
Owner 白强
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