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Usage of hematoxylin for preparing drug for treating immunity glomerulonephritis

A technology of glomerulonephritis and hematoxylin, which is applied in the direction of drug combination, pharmaceutical formula, allergic diseases, etc., and can solve problems such as loss of function, lack of selectivity and specificity, organ or plant organ dysfunction, etc.

Active Publication Date: 2018-11-23
HARBIN MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Although the clinical application of CSA and other immunosuppressive drugs has created a new era for the treatment of organ transplantation and immune diseases, most of these drugs lack selectivity and specificity. Malignant tumors, etc.; on the other hand, immunosuppressants themselves have high toxicity to the body and many side effects, and severe cases can cause dysfunction or even loss of function of internal organs or implanted organs

Method used

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  • Usage of hematoxylin for preparing drug for treating immunity glomerulonephritis
  • Usage of hematoxylin for preparing drug for treating immunity glomerulonephritis
  • Usage of hematoxylin for preparing drug for treating immunity glomerulonephritis

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 Hematoxylin treats the drug efficacy test of membranous nephropathy

[0035] 1. Materials and methods

[0036] 1.1 Materials

[0037] 1.1.1 Experimental animals

[0038] Fifty healthy male clean SD rats (body weight 200-250 g) were purchased from the Animal Experiment Center of the Second Affiliated Hospital of Harbin Medical University. During the experiment, the experimental animals were fed in the Animal Experiment Center of the Second Affiliated Hospital of Harbin Medical University. The animals were adaptively fed for one week before the experiment, and had free access to food and water during the experiment.

[0039] 1.1.2 Main experimental drugs

[0040] Hematoxylin: Hematoxylin finished product (purity, 95%) was purchased from Harbin Hongbo Co., Ltd.

[0041] Tacrolimus Capsules (Kangren): Approval Number: Guoyao Zhunzi H20084522. Production unit: Zhejiang Hongsheng Pharmaceutical Co., Ltd.

[0042] Prednisone (prednisone acetate tablets): appro...

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Abstract

The invention discloses a usage of hematoxylin for preparing a drug for treating immunity glomerulonephritis. It is discovered from research to the immunity glomerulonephritis of a membranous nephropathy animal model that the hematoxylin achieves a purpose of treating membranous nephropathy through the following three aspects: 1) the hematoxylin has functions of reducing a urine protein, improvinglipid metabolism disorder, and improving a plasma albumin level; 2) the hematoxylin has the function of improving a kidney tissue pathomorphism injury; and 3) the hematoxylin has the function of reducing a vascular endothelial growth factor (VEGF) level in blood serum, through inhibiting VEGF secretion, glomerular filtration membrane permeability is adjusted, an excretion rate of the urine protein is reduced, and a renal function is protected. The usage is capable of acknowledging that the hematoxylin has the adjusting and treating functions to the immunity glomerulonephritis, and providing anew technical measure for therapy of the immunity glomerulonephritis, and has extensive application prospect in the field of the therapy of the immunity glomerulonephritis.

Description

technical field [0001] The invention relates to a new use of hematoxylin, in particular to the use of hematoxylin in treating immune glomerulonephritis, and the invention belongs to the technical field of traditional Chinese medicine development. Background technique [0002] Immune glomerulonephritis is a chronic glomerular disease originating in the kidney caused by various etiologies. The etiology of most immune nephritis is still unclear. Research has shown that various microorganisms, including bacteria, viruses, rickettsia, protozoa, etc., can cause this disease through the pathogenesis of immunity. The therapeutic effect and prognosis of immune nephritis are closely related to the type of pathological changes. Internationally, immune nephritis is divided into following histopathological changes: 1. Minimal lesion type. 2. Membranous nephropathy. 3. Mesangial proliferative nephritis (including IgA nephritis). 4. Endothelial-mesangial proliferative nephritis. 5. Mes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P13/12A61P37/02
CPCA61K31/352A61P13/12A61P37/02
Inventor 胡克杰赵学谦刘国建宋成收陈希源
Owner HARBIN MEDICAL UNIVERSITY
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