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Use of hematoxylin in preparing medicine for treating immune glomerulonephritis

A technology of glomerulonephritis and hematoxylin, which is applied in the direction of drug combination, pharmaceutical formula, allergic diseases, etc., and can solve the problems of organ or plant organ dysfunction, high toxicity, lack of selectivity and specificity, etc.

Active Publication Date: 2021-05-04
HARBIN MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Although the clinical application of CSA and other immunosuppressive drugs has created a new era for the treatment of organ transplantation and immune diseases, most of these drugs lack selectivity and specificity. Malignant tumors, etc.; on the other hand, immunosuppressants themselves have high toxicity to the body and many side effects, and severe cases can cause dysfunction or even loss of function of internal organs or implanted organs

Method used

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  • Use of hematoxylin in preparing medicine for treating immune glomerulonephritis
  • Use of hematoxylin in preparing medicine for treating immune glomerulonephritis
  • Use of hematoxylin in preparing medicine for treating immune glomerulonephritis

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 Hematoxylin treats the drug efficacy test of membranous nephropathy

[0035] 1. Materials and methods

[0036] 1.1 Materials

[0037] 1.1.1 Experimental animals

[0038] Fifty healthy male clean SD rats (body weight 200-250 g) were purchased from the Animal Experiment Center of the Second Affiliated Hospital of Harbin Medical University. During the experiment, the experimental animals were fed in the Animal Experiment Center of the Second Affiliated Hospital of Harbin Medical University. The animals were adaptively fed for one week before the experiment, and had free access to food and water during the experiment.

[0039] 1.1.2 Main experimental drugs

[0040] Hematoxylin: Hematoxylin finished product (purity, 95%) was purchased from Harbin Hongbo Co., Ltd.

[0041] Tacrolimus Capsules (Kangren): Approval Number: Guoyao Zhunzi H20084522. Production unit: Zhejiang Hongsheng Pharmaceutical Co., Ltd.

[0042] Prednisone (prednisone acetate tablets): appro...

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Abstract

The invention discloses the use of hematoxylin in preparing medicine for treating immune glomerulonephritis. In the study of immune glomerulonephritis in the animal model of membranous nephropathy, it was found that hematoxylin can achieve the purpose of treating membranous nephropathy through at least the following three aspects: 1) Hematoxylin can reduce urinary protein and improve lipid metabolism Disorders, the effect of increasing plasma albumin levels. 2) Hematoxylin can improve the pathological damage of renal tissue. 3) Hematoxylin has the effect of reducing the level of vascular endothelial growth factor (VEGF) in serum, and by inhibiting the secretion of VEGF, it can regulate the permeability of glomerular filtration membrane, reduce the excretion rate of urinary protein, and protect kidney function. The present invention clarifies that hematoxylin has regulating and therapeutic effect on immune glomerulonephritis, provides a kind of new technical means for the treatment of immune glomerulonephritis, and will have wide application in the treatment field of immune glomerulonephritis application prospects.

Description

technical field [0001] The invention relates to a new use of hematoxylin, in particular to the use of hematoxylin in treating immune glomerulonephritis, and the invention belongs to the technical field of traditional Chinese medicine development. Background technique [0002] Immune glomerulonephritis is a chronic glomerular disease originating in the kidney caused by various etiologies. The etiology of most immune nephritis is still unclear. Research has shown that various microorganisms, including bacteria, viruses, rickettsia, protozoa, etc., can cause this disease through the pathogenesis of immunity. The therapeutic effect and prognosis of immune nephritis are closely related to the type of pathological changes. Internationally, immune nephritis is divided into following histopathological changes: 1. Minimal lesion type. 2. Membranous nephropathy. 3. Mesangial proliferative nephritis (including IgA nephritis). 4. Endothelial-mesangial proliferative nephritis. 5. Mes...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P13/12A61P37/02
CPCA61K31/352A61P13/12A61P37/02
Inventor 胡克杰赵学谦刘国建宋成收陈希源
Owner HARBIN MEDICAL UNIVERSITY
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