Method for predicting drug residues in grass carp tissue with physiological pharmacokinetic model

A technology of physiological pharmacokinetics and model prediction, applied in measurement devices, scientific instruments, instruments, etc., can solve problems such as inability to meet requirements, time-consuming, manpower and material resources, etc., to reduce the number, reduce pollution, reduce The effect of the dose of the drug

Inactive Publication Date: 2015-01-07
YANGTZE RIVER FISHERIES RES INST CHINESE ACAD OF FISHERY SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method takes a very long time and consumes a lot of manpower and material resources
There are many kinds of animals in aquaculture, and changes in species, physiology, diseases and external environments have a relatively large impact on drug residues, so this method can no longer meet the requirements

Method used

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  • Method for predicting drug residues in grass carp tissue with physiological pharmacokinetic model
  • Method for predicting drug residues in grass carp tissue with physiological pharmacokinetic model
  • Method for predicting drug residues in grass carp tissue with physiological pharmacokinetic model

Examples

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Embodiment 1

[0033] A method for predicting drug residues in grass carp tissue by a physiological pharmacokinetic model, comprising the following steps:

[0034] This example takes norfloxacin as an example to predict the drug residue of norfloxacin in grass carp tissues. Norfloxacin is a small molecule substance. For the drug residue in aquatic products, we focus on edible tissues and vital organs Therefore, the established model does not include organs containing special physiological barriers, so it can be assumed that the speed and degree of their distribution in tissues mainly depends on the blood flow flowing through tissues and organs, that is, obeys the blood flow rate-limiting distribution ; Norfloxacin is absorbed from the gastrointestinal tract into the blood circulation as a first-order rate process; norfloxacin is metabolized in the liver and eliminated from the kidneys, and obeys the first-order kinetic process. The chamber of the physiological pharmacokinetic model described...

Embodiment 2

[0062] Controlled experiment:

[0063] According to the clinical dosage, the grass carp with the same specifications as in Example 1 is administered by 3d continuous oral irrigation, and the dosage is 10mg / kg b.w., and then collected at 1, 2, 3, 7, 14, 21, 30d after irrigation Grass carp muscle, liver and kidney, the concentration of norfloxacin was determined by high performance liquid chromatography, and the residue data of norfloxacin in grass carp tissues were obtained. The results are as follows Figure 1-Figure 3 shown.

[0064] Table 1 Predicted and measured concentrations of norfloxacin in grass carp tissues ( μ g / kg)

[0065]

[0066] -: Below the detection limit

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Abstract

The invention discloses a method for predicting drug residues in grass carp tissue with a physiological pharmacokinetic model. The method comprises steps as follows: A, collecting physiological dissection parameters of grass carps; B, obtaining drug specificity parameters of norfloxacin in bodies of the grass carps; C, establishing the five-chamber model by using acslXtreme software; D, evaluating the model. According to the method, the five-chamber physiological pharmacokinetic model is established, and residue elimination curves of the norfloxacin in muscles, livers and kidneys of the grass carps are fitted successfully and are identical with measured values. The method has the advantages of capability of saving the cost substantially, convenience in operation and the like and is applicable to prediction of common drug residues in the grass carps.

Description

technical field [0001] The invention belongs to the field of analysis of drug residues in aquatic products, and in particular relates to a method for predicting drug residues in grass carp tissues with a physiological pharmacokinetic model. Background technique [0002] In recent years, aquatic drugs have become more and more widely used. Due to more and more incidents of food poisoning caused by drug residues and affecting the export of aquatic products, drug residues in aquatic products have become a hot spot of social concern. The traditional drug residue detection method is first to identify the main metabolites in aquatic animals, determine the residue markers and target tissues, and then carry out the detection through the residue elimination test, and then determine the maximum residue limit and drug withdrawal period. This method takes a very long time and consumes a lot of manpower and material resources. There are many kinds of animals in aquaculture, and changes ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 胥宁艾晓辉杨秋红董靖刘永涛杨移斌
Owner YANGTZE RIVER FISHERIES RES INST CHINESE ACAD OF FISHERY SCI
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