Application of composition in preparation of medicine for treating atherosclerosis

Abstract

The invention discloses application of a composition in preparation of a medicine for treating atherosclerosis. The composition contains a therapeutically-effective amount of a glucokinase inhibitor and a therapeutically-effective amount of pentitol. The composition of the medicine can be used for effectively treating the atherosclerosis.

Description

technical field [0001] The invention relates to a medicine, in particular to the application of a composition in the medicine for treating atherosclerosis. Background technique [0002] Atherosclerosis (atherosclerosis) is the most common and most important type of vascular disease of arteriosclerosis, which is characterized by the involvement of arterial lesions starting from the intima. Generally, there is accumulation of lipids and complex carbohydrates, hemorrhage and thrombosis, fibrous tissue hyperplasia and calcium deposition, and gradual degeneration and calcification of the arterial media. The lesions often involve elastic and large and medium muscular arteries. Once they develop enough to block Arterial lumen, the tissue or organ supplied by the artery will be ischemic or necrotic. Atherosclerosis is called atherosclerosis because of the yellow ather-like appearance of lipids that build up in the lining of the arteries. [0003] Atherosclerosis is a disease affec...

AI Technical Summary

Problems solved by technology

[0014] Currently used lipid-lowering drugs and anti-platelet drugs mainly have two problems: (1) blocking the function of substances required for normal physiological operations, such as HMG-CoA reductase in oxidatively modified low-density lipoproteins leading to atherosclerosis The human body has important physiological functions, and the use of drugs such as HMG-CoA reductase inhibitors will inhibit the normal physiological functions of this enzyme in the human body

Of course, the use of this drug can reduce the accumulation of lipids to a certain extent, but it will also cause the human body's own HMG-CoA enzyme to lose other physiological functions, and long-term use will affect the normal operation of the body

(2) This type of drug causes great damage to liver and kidney functions, and long-term use will inevitably cause liver and kidney diseases

However, most people are only used to looking at the curative effect, and are unwilling to pay attention to the side effects of drugs

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