A kind of fluorescent conjugated compound and its application

Abstract

A fluorescent conjugate compound and uses thereof. The fluorescent conjugate compound consists of free fatty acids marked by fluorescent molecules, is useful for detecting precancerous lesion cells or cancer cells, and also is useful for the assessment of human tumor and precancerous diseases, pathologic biopsy, surgical resection range determination, as well as the preparation of drug or tracer reagents for detecting tumor or precancerous disease.

Description

technical field [0001] The invention relates to a fluorescent conjugated compound and its application, in particular to a fluorescent molecularly labeled fatty acid and its application, and belongs to the technical field of medicine. Background technique [0002] Tumor is a new organism formed by the abnormal proliferation of cells in the body. This proliferation is an uncontrollable malignant proliferation that eventually forms a tumor. Normal cells in the body will proliferate and differentiate to repair the damage when they are damaged, while tumor cells lose the ability to differentiate and mature, proliferate indefinitely, squeeze the surrounding normal tissues and carry out distant metastasis. [0003] The survival period of cancer patients is closely related to the stage of the tumor at the time of diagnosis. If the tumor can be detected early, the tumor can be controlled or cured. The clinical staging of tumors describes the severity and extent of malignant tumors b...

AI Technical Summary

Problems solved by technology

[0007] In view of the complexity and out-of-control of the above-mentioned tumor occurrence and development process, it is difficult to know the stage and degree of disease development, and for latent tumors, because the structure and function of the tissue do not change significantly, only rely on the physician's clinical experience and tumor macroscopic morphology, Judging by serum tumor markers, it is still difficult to detect early colon cancer, lung cancer, breast cancer, prostate cancer, cervical cancer, esophageal cancer, bladder cancer, melanoma, leukemia, lymphoma, etc.

[0008] 2. Defects of current diagnosis and treatment technology: At present, the early detection of tumors mainly relies on tumor marker examination, imaging and pathological examination and other means

At present, fatty acid molecular tracer technology labeled with radioactive elements is mainly used to study the absorption and metabolism of fatty acids, which requires special detection instruments and is relatively expensive.

[0013] In the prior art, there is no fluorescent conjugated compound composed of free fatty acids labeled with fluorescent molecules, and the detection of human tumors and precancerous diseases can be achieved based on the difference in the absorption or metabolism of free fatty acids in the fluorescent conjugated compound between normal cells and tumor cells. Applications in disease assessment, pathological biopsy, and extent of surgical resection

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