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Traditional Chinese medicine composition for treating long-term anticoagulation for patients with atrial fibrillation and preparation method thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition for the treatment of atrial fibrillation, can solve the problems of no large-scale clinical application of anticoagulant drugs, no clinical experience in domestic application, etc., and achieve the effects of improving systemic function and safe clinical use.

Inactive Publication Date: 2015-05-20
周辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the anticoagulant drugs represented by rivaroxaban have not been used in clinical practice on a large scale, and there is no clinical experience in domestic application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of embodiment 1 hard capsule

[0029] (1) Weigh each raw material decoction pieces according to the following weight: 1500g of angelica, 1500g of peach kernel, 2000g of safflower, 1500g of Trichosanthes chinensis, 1500g of Citrus aurantii, 1500g of Achyranthes bidentata, 500g of Sanqi, 800g of bellflower, 800g of tangerine peel, 800g of red peony root, Bupleurum bupleuri 1500g, dried blood 400g.

[0030] (2) Distill tangerine peel, peach kernel, safflower, and rhizome respectively, extract volatile oil, after adding β-cyclodextrin of 10 times of weight of respective volatile oil, add 3 times of weight of β-cyclodextrin again and be 40% Mix with ethanol, homogenize with a colloid mill for 15 minutes for clathrate, refrigerate the clathrate homogeneous solution for 24 hours, then filter, dry the clathrate at 40°C, and pulverize it for later use;

[0031] (3) Angelica sinensis, Trichosanthes chinensis, Citrus aurantium, Achyranthes bidentata, Platycodon gr...

Embodiment 2

[0037] The preparation of embodiment 2 powder

[0038] Weigh each raw material according to the following weight: Angelica 1500g, peach kernel 1500g, safflower 2000g, Trichosanthes 1500g, Fructus aurantium 1500g, Achyranthes bidentata 1500g, Panax notoginseng 500g, bellflower 800g, orange peel 800g, red peony 800g, Bupleurum 1500g, blood Drain 400g.

[0039] After pulverizing the above raw materials, pass through a 800-mesh sieve to obtain the product.

Embodiment 3

[0040] The preparation of embodiment 3 granules

[0041] (1) Weigh each raw material according to the following weight: Angelica 1500g, peach kernel 1500g, safflower 2000g, Trichosanthes 1500g, Citrus aurantii 1500g, Achyranthes bidentata 1500g, Panax notoginseng 500g, Bellflower 800g, Tangerine peel 800g, Chishao 800g, Bupleurum 1500g, dried blood 400g.

[0042] (2) Distill tangerine peel, peach kernel, safflower, and rhizome respectively, extract volatile oil, after adding β-cyclodextrin of 10 times of weight of respective volatile oil, add 3 times of weight of β-cyclodextrin again and be 40% Mix with ethanol, homogenize with a colloid mill for 15 minutes for clathrate, refrigerate the clathrate homogeneous solution for 24 hours, then filter, dry the clathrate at 40°C, and pulverize it for later use;

[0043] (3) Angelica sinensis, Trichosanthes chinensis, Citrus aurantium, Achyranthes bidentata, Platycodon grandiflorum, Radix paeoniae Ruba, Radix Bupleurum, Panax notoginse...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating long-term anticoagulation for patients with atrial fibrillation and a preparation method of the traditional Chinese medicine composition, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw medicinal materials in parts by weight: 10-20 parts of Chinese angelica, 10-20 parts of peach kernels, 15-45 parts of safflowers, 10-20 parts of trichosanthes, 10-20 parts of bitter oranges, 10-20 parts of twotooth achyranthes roots, 2-9 parts of sanchi, 5-15 parts of platycodon grandiflorum, 5-15 parts of tangerine peels, 5-15 parts of red peony, 10-20 parts of Chinese thorowax roots and 3-5 parts of dragon blood. An experiment proves that the traditional Chinese medicine composition can be used for preventing or treating atrial fibrillation, especially severe bleeding complications which are caused during prevention treatment of atrial fibrillation anticoagulation; meanwhile, the composition also has the characteristics of activating blood and removing stasis and inspiring vital energy and blood, and is mild in drug properties, and warm heat and dryness heat are avoided; the pathological factors such as vascular endothelial injury and intravascular vortex formation can be effectively corrected, and the prognosis of large vascular restenosis and occlusion can be improved.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating atrial fibrillation, in particular to a traditional Chinese medicine composition for anticoagulant treatment of atrial fibrillation. The invention also relates to a preparation method of the traditional Chinese medicine composition, which belongs to the field of traditional Chinese medicine. Background technique [0002] The diseases caused by the two pathological processes of thrombosis and thromboembolism are clinically called thrombotic diseases. Thrombotic disease is a serious threat to human life and health, and its incidence rate ranks first among various diseases, and it has gradually increased in recent years. It is one of the focuses and hotspots of contemporary medical research. At present, anticoagulant therapy has entered a new era. With the increase of thrombotic diseases, the indications for anticoagulant continue to expand. Anticoagulation can reduce the oc...

Claims

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Application Information

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IPC IPC(8): A61K36/889A61K36/896A61P9/06A61P7/02
Inventor 曾强周辉
Owner 周辉
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