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A kind of loaded arsenic agent and its preparation method and application

A solution and silicon dioxide technology, applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as liver failure, dose toxicity, affecting tumor absorption of drugs, etc. To achieve strong anti-cancer effect, the effect of cancer treatment

Active Publication Date: 2018-04-24
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, clinical treatment is limited by dose toxicity, liver failure, and side effects such as peripheral neuropathy at the drug site
In addition, the rapid renal clearance metabolism of ions affects the absorption of drugs by tumors, which is not conducive to the effect of ATO on cancerous tissue sites.

Method used

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  • A kind of loaded arsenic agent and its preparation method and application
  • A kind of loaded arsenic agent and its preparation method and application
  • A kind of loaded arsenic agent and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: MAsO with a radius of 5 nm x Preparation of Nanomaterials

[0033] Add 5mL cyclohexane to a 25mL round bottom flask, add 2mL Co-520 at the same time, and add 0.1M nickel acetate (or zinc acetate) solution 326μL, and the same volume of arsenic solution (0.1M NaAsO 2 ,0.016M Na 2 SiO 3 , [AsO 2 - ]:[SiO 3 2- ]=25:4). The mixed solution was stirred (rotating speed: 800r / min), mixed evenly, and kept at the rotating speed for reaction for 5h. Then wash out with ethanol and ultrapure water to get MAsO with a radius of 5nm x (M=Ni, Zn) nanomaterials.

Embodiment 2

[0034] Example 2: NiAsO x @SiO 2 Preparation of anticancer nanomedicine

[0035] Example 1 NiAsO x After the reaction is complete, continue to add 60 μL of tetraethoxysilane and 100 μL of ammonia water to the reaction system, stir the mixed solution at room temperature for 16 hours (rotating at 800 r / min), and then add 30 μL of amphoteric sulfonic acid siloxane aqueous solution (95%) , and then react for 5h. Then add 10 mL of absolute ethanol to precipitate the product, centrifuge to discard the supernatant, continue to wash the precipitate with absolute ethanol and water several times, and finally the surface-modified zwitterionic NiAsOx@SiO 2 Anticancer nano-medicines are dispersed in water and placed at 4°C for use.

Embodiment 3

[0036] Embodiment three: ZnAsO x @SiO 2 Preparation of anticancer nanomedicine

[0037] To be embodiment one ZnAsO x The response is complete. Continue to add 60 μL of tetraethoxysilane and 100 μL of ammonia water, stir the mixed solution at room temperature for 16 h (rotation speed: 800 r / min), then add 30 μL of amphoteric sulfonic acid siloxane aqueous solution (95%), and react for 5 h. Then add 10mL of absolute ethanol to precipitate the product, centrifuge to discard the supernatant, continue to wash the precipitate with absolute ethanol and water several times, and finally surface-modified zwitterionic ZnAsO x @SiO 2 Anticancer nano-medicines are dispersed in water and placed at 4°C for use.

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Abstract

An arsenic-loaded agent and its preparation method and application relate to an arsenic drug. The arsenic-loading agent is an arsenite complex, represented by MAsOx, wherein M refers to a transition metal, As refers to arsenic, and x=2 to 3; the preparation method of the arsenic-loading agent: dissolve Co-520 in cyclohexane solution, Add transition metal salt solution and arsenic solution in sequence, the arsenic solution is NaAsO2 and Na2SiO3, [AsO2-]:[SiO32-]=25:4. The loaded arsenic agent can be used in the preparation of anticancer drugs. The preparation method of the arsenic agent silicon dioxide nanometer anticancer drug is as follows: in the loaded arsenic agent, after adding tetraethoxysilane and ammonia water, then adding an amphoteric sulfonic acid siloxane aqueous solution, adding absolute ethanol after the reaction to precipitate the product, Discard the supernatant by centrifugation, wash the precipitate with absolute ethanol and water, and finally disperse the arsenic silicon dioxide nanoparticles in water to obtain the arsenic silicon dioxide nanometer anticancer drug.

Description

technical field [0001] The invention relates to arsenic medicine, in particular to an arsenic-loaded medicine and its preparation method and application. Background technique [0002] In the treatment of cancer, drug therapy can effectively inhibit tumor growth and prolong the survival time of patients. The research and development of anticancer drugs has always attracted the attention of scientists. Traditional anticancer drugs are due to poor solubility, fast metabolism, or toxic side effects. Injury and other shortcomings, the expected therapeutic effect cannot be achieved during the treatment process. If the drug is embedded or attached to the nanoparticle, it can not only effectively overcome the shortcomings of traditional drugs, but also improve the targeting efficiency and control the pharmacokinetic process, thereby improving the drug utilization (Mura, S., Nicolas, J . & Couvreur, P., Nat. Mater., 2013, 12, 991). Among many nanomaterials, porous silica (including...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K33/36A61K47/04A61P35/00
Inventor 高锦豪张宗珺池小琴王效民赵征寰刘晗玉
Owner XIAMEN UNIV
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